Sensitivity and Specificity of the Newborn Infant Parasympathetic Evaluation Index in Pain Assessment of Very Low Birth Weight Infants

Fernández, José Uberos; Campos‐Martínez, Ana; Ruiz-López, Aida; Fernández-Marín, Elizabeth; García-Serrano, J.L.

doi:10.1055/s-0042-1755464

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…However, other studies found no correlation with pain scores (45,46). Moreover, the reported diagnostic performance varied considerably between studies, with the AUC ranging from 0.56 to 0.93 (41,42,44,(46)(47)(48). NIPE generally performed better in neonates with higher levels of pain compared with those with mild pain.…”

Section: Heart Rate Variabilitymentioning

confidence: 91%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

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Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.

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Section: Heart Rate Variabilitymentioning

confidence: 91%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

View full text Add to dashboard Cite

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“…Ivanic et al [ 20 ] observed that NIPE monitor is useful for postoperative pain management. In the same way, Uberos et al [ 23 ] describe that NIPE index is a good method to measure nociceptive stimuli in very low birth weight newborns.…”

Section: How To Assess Neonatal Pain: Pain Assessment Scalesmentioning

confidence: 99%

Dexmedetomidine: An Alternative to Pain Treatment in Neonatology

et al. 2023

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Infants might be exposed to pain during their admissions in the neonatal intensive care unit [NICU], both from their underlying conditions and several invasive procedures required during their stay. Considering the particularities of this population, recognition and adequate management of pain continues to be a challenge for neonatologists and investigators. Diverse therapies are available for treatment, including non-pharmacological pain management measures and pharmacological agents (sucrose, opioids, midazolam, acetaminophen, topical agents…) and research continues. In recent years one of the most promising drugs for analgesia has been dexmedetomidine, an alpha-2 adrenergic receptor agonist. It has shown a promising efficacy and safety profile as it produces anxiolysis, sedation and analgesia without respiratory depression. Moreover, studies have shown a neuroprotective role in animal models which could be beneficial to neonatal population, especially in preterm newborns. Side effects of this therapy are mainly cardiovascular, but in most studies published, those were not severe and did not require specific therapeutic measures for their resolution. The main objective of this article is to summarize the existing literature on neonatal pain management strategies available and review the efficacy of dexmedetomidine as a new therapy with increasing use in the NICU.

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