Sensitivity and specificity of photopic negative response of focal electoretinogram to detect glaucomatous eyes

Machida, Shigeki; Tamada, Kunifusa; Oikawa, Taku; Yokoyama, Daisuke; Kaneko, Masaru; Kurosaka, Daijiro

doi:10.1136/bjo.2009.161166

Cited by 33 publications

(32 citation statements)

References 16 publications

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“…12,15 PhNR is also selectively reduced in eyes with optic nerve atrophy, which is induced by trauma, compression, inflammation, ischemia, or gene mutation. [8][9][10] Our results provide additional evidence that focal macular PhNR is immediately and strongly attenuated by the onset of optic neuritis and that PhNR did not improve even after patients were treated with systemic corticosteroids, which resulted to improved visual acuity and visual field but not optic atrophy.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have used focal macular ERG to record the PhNR from localized retinal areas. [12][13][14][15] Machida et al 12,15 suggested that focal PhNR can detect early glaucoma with higher sensitivity and specificity than full-field PhNR. Therefore, the reduction of focal macular PhNR amplitude in patients with optic neuritis suggests that an inner retinal dysfunction of the macula already exists at the onset of symptoms.…”

Section: Reduction Of Focal Macular Erg In Patients With Optic Neuritismentioning

confidence: 99%

“…[8][9][10] Several researchers measured PhNR by using focal macular ERG in humans and monkeys. [11][12][13][14][15] Focal macular PhNR detected early glaucoma with higher sensitivity and specificity than full-field PhNR. 5,15 Most patients with acute idiopathic demyelinating optic neuritis have good visual acuity.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15] Focal macular PhNR detected early glaucoma with higher sensitivity and specificity than full-field PhNR. 5,15 Most patients with acute idiopathic demyelinating optic neuritis have good visual acuity. However, 5-10% of patients recover poorly, 16 and many more patients notice residual qualitative deficits.…”

Section: Introductionmentioning

confidence: 99%

“…A number of studies have been done on recording PhNR from the macula in patients and monkeys with optic nerve disease, including glaucoma and optic nerve atrophy, 2,11,12,15 however, to our knowledge, the change in the focal macular PhNR during vision recovery from optic neuritis has not been investigated yet. This is important to gain a better understanding of the functional mechanisms during vision recovery, and the prediction of visual prognosis of optic neuritis.…”

Section: Introductionmentioning

confidence: 99%

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Focal macular photopic negative response in patients with optic neuritis

Nakamura

Miyamoto

Yokota

et al. 2011

Eye

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Purpose To investigate, by focal macular electroretinography (ERG), the change of photopic negative response (PhNR) in the recovery of visual function in patients with optic neuritis. Methods Focal macular ERG was recorded from nine patients with acute optic neuritis (38.6±10.2 years). The photostimulator device projected 151 visual angle spotlight onto the macula. Focal macular ERG recording was performed at the onset and at 1 month and 6 months after the onset of optic neuritis. The results were compared between each recording for seven of the patients. Results All patients decreased in the vision below 20/100 and had central scotoma. Vision improved more than 20/20 within 1 month and full-visual field recovered within 6 months after the onset in all patients. The amplitude of the a-wave, b-wave, and PhNR of focal macular ERG at the onset was significantly attenuated in eyes with optic neuritis (66.8±15.5, 65.8±17.7, and 65.2±14.4% of normal control, respectively). The amplitude of the a-wave and b-wave increased gradually after steroid pulse therapy. The increase in a-wave amplitude was significant at 6 months (P ¼ 0.046), whereas the PhNR amplitude did not show any significant change over 6 months after the onset of optic neuritis. Conclusions Our results suggest that inflammation at the onset of optic neuritis leads to functional deficits that extend to at least the inner nuclear layers of the retina, and that all but the ganglion cell layers of retina recover.

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