Sensitivity and specificity of a rapid point-of-care test for active yaws: a comparative study

Ayove, Telek; Houniei, Wendy; Wangnapi, Regina; Bieb, Sibauk; Kazadi, Walter; Luke, Lisol-Nirau; Manineng, Clement; Moses, Penias; Paru, Raymond; Esfandiari, Javan; Alonso, Pedro L.; Lazzari, Elisa de; Bassat, Quique; Mabey, David; Mitjà, Oriol

doi:10.1016/s2214-109x(14)70231-1

Cited by 51 publications

(40 citation statements)

References 16 publications

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“…In this study, we found that in a community surveillance setting, the sensitivity and specificity of the DPP rapid diagnostic test were markedly lower than in the only previous evaluation of the assay for use in clinically active yaws [15]. There was a strong association between the sensitivity of both the T2 line (against gold standard RPR) and RPR titre and also between the T1 line (against gold standard TPPA) and RPR titre.…”

Section: Discussionmentioning

confidence: 51%

Evaluation of a Rapid Diagnostic Test for Yaws Infection in a Community Surveillance Setting

Marks

Gonçalves

Vahi³

et al. 2014

PLoS Negl Trop Dis

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Yaws is a non-venereal treponemal infection caused by Treponema pallidum ssp. pertenue. The WHO has launched a worldwide control programme, which aims to eradicate yaws by 2020. The development of a rapid diagnostic test (RDT) for serological diagnosis in the isolated communities affected by yaws is a key requirement for the successful implementation of the WHO strategy. We conducted a study to evaluate the utility of the DPP test in screening for yaws, utilizing samples collected as part of a community prevalence survey conducted in the Solomon Islands. 415 serum samples were tested using both traditional syphilis serology (TPPA and quantitative RPR) and the Chembio DPP Syphilis Screen and Confirm RDT. We calculated the sensitivity and specificity of the RDT as compared to gold standard serology. The sensitivity of the RDT against TPPA was 58.5% and the specificity was 97.6%. The sensitivity of the RDT against RPR was 41.7% and the specificity was 95.2%. The sensitivity of the DPP was strongly related to the RPR titre with a sensitivity of 92.0% for an RPR titre of >1/16. Wider access to DPP testing would improve our understanding of worldwide yaws case reporting and the test may play a key role in assessing patients presenting with yaws like lesions in a post-mass drug administration (MDA) setting.

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Section: Discussionmentioning

confidence: 51%

Evaluation of a Rapid Diagnostic Test for Yaws Infection in a Community Surveillance Setting

Marks

Gonçalves

Vahi³

et al. 2014

PLoS Negl Trop Dis

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“…Until now, no macrolide treatment failures in the treatment of yaws have been reported. [19][20][21] A wide spectrum of macrolide-resistance mutations in 23S rRNA gene have been reported in other bacteria. However, only the A2058G and A2059G mutations (the position numbers correspond to positions on the Escherichia coli 23S rRNA gene) have been identified in TPA from clinical samples.…”

Section: Macrolide Failures In Syphilis Treatment and Frequency Of Mumentioning

confidence: 99%

Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?

Šmajs

Paštěková

Grillová

2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Treponema pallidum ssp. pallidum (TPA) causes over 10 million new cases of syphilis worldwide whereas T. pallidum ssp. pertenue (TPE), the causative agent of yaws, affects about 2.5 million people. Although penicillin remains the drug of choice in the treatment of syphilis, in penicillin-allergic patients, macrolides have been used in this indication since the 1950s. Failures of macrolides in syphilis treatment have been well documented in the literature and since 2000, there has been a dramatic increase in a number of clinical samples with macrolide-resistant TPA. Scarce data regarding the genetics of macrolide-resistant mutations in TPA suggest that although macrolide-resistance mutations have emerged independently several times, the increase in the proportion of TPA strains resistant to macrolides is mainly due to the spread of resistant strains, especially in developed countries. The emergence of macrolide resistance in TPA appears to require a two-step process including either A2058G or A2059G mutation in one copy of the 23S rRNA gene and a subsequent gene conversion unification of both rRNA genes. Given the enormous genetic similarity that was recently revealed between TPA and TPE strains, there is a low but reasonable risk of emergence and spread of macrolide-resistant yaws strains following azithromycin treatment.

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“…The sensitivity of the ChemBio DPP syphilis screen was correlated to higher RPR titers, having a sensitivity of 92.0% for an RPR titer of >1:16. This study showed a lower sensitivity and specificity compared to the only prior evaluation of this assay [27], suggesting that the test is most useful for confirmation in patients with highly active clinical disease [26]. This rapid screening test does not perform as well in patients with latent disease nor useful in areas with low prevalence [26].…”

Section: Diagnosismentioning

confidence: 65%

Yaws: Rebound of a forgotten disease

Santos¹,

Faldetta²,

Zaenglein³

2015

Glob Dermatol

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Yaws is a destructive soft-tissue infection caused by the bacterium Treponema pallidum pertenue that has remained on the World Health Organization's agenda for eradication for more than half a century. Affecting predominantly young children living in warm, humid settings, the recurrence of yaws is a result of a stall in worldwide surveillance, continuing to earn its place on the list of neglected tropical diseases. This lack of monitoring now limits our understanding of its prevalence. The combination of disease latency and poor recognition may lead to unnecessary morbidity. A renewed campaign against this devastating, yet treatable disease has offered new hope. The purpose of this review is to increase the awareness of the condition and discuss the new approach amongst the global health community.

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Sensitivity and specificity of a rapid point-of-care test for active yaws: a comparative study

Abstract: Chembio Diagnostic Systems, Newcrest Mining, and the Papua New Guinea National Department of Health.

Cited by 51 publications

References 16 publications

Evaluation of a Rapid Diagnostic Test for Yaws Infection in a Community Surveillance Setting

Evaluation of a Rapid Diagnostic Test for Yaws Infection in a Community Surveillance Setting

Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?

Yaws: Rebound of a forgotten disease

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