Sensitivity and depth penetration of continuous wave versus frequency-domain photon migration near-infrared fluorescence contrast-enhanced imaging

Houston, Jessica P.; Thompson, Alan Bruce; Gurfinkel, Michael; Sevick‐Muraca, Eva M.

doi:10.1562/0031-8655(2003)078<0103:sadpoc>2.0.co;2

Cited by 18 publications

(35 citation statements)

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“…Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy of visceral blood supply and evaluation of bowel perfusion (1)(2)(3)(4)(5)(6)(7)(8)(9). Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

“…Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

“…The many applications of ICG-enhanced fluorescence imaging in guided surgical procedures include intraoperative angiography, laparoscopic cholecystectomy, extrahepatic cholangiography, colorectal resection, living-donor nephrectomy, laparoscopic kidney autotransplantation, lymph node mapping and dissection, and various other procedures (9,20,21). Indocyanine green-enhanced fluorescence imaging is now well established as simple, inexpensive, and effective (1)(2)(3)(4)(5)(6)(7)(8) and is expected to become a standard technique for many diagnostic and oncological purposes in the near future. However, further large scale studies are needed to clarify its specific advantages and disadvantages in large populations.…”

Section: Icg-enhanced Fluorescence Imaging In Surgerymentioning

confidence: 99%

“…Recently, indocyanine green (ICG)-enhanced fluorescence has been used to improve visualization and to provide detailed anatomical information during different surgical procedures, especially laparoscopic surgery (1)(2)(3)(4)(5)(6)(7)(8). Fluorescent optical guidance minimizes inadvertent tissue injury while enhancing procedural efficiency (9).…”

Section: Introductionmentioning

confidence: 99%

“…Indocyanine green is a water-soluble anionic amphiphilic tricarbocyanine dye with a molecular weight of 774.96 Da (1)(2)(3)(4)(5)(6)(7)(8)(9). This dye can be injected into the human bloodstream with practically no adverse effects (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and becomes fluorescent upon excitation by a laser beam or by light with a wavelength in the near infra-red (NIR) spectrum (approximately 820 nm).…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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Identification of the parathyroid glands during thyroid surgery may prevent their inadvertent surgical removal and thus provide a better postoperative quality of life. Nevertheless, the most common "technique" for intraoperative evaluation of perfusion of parathyroid gland tissues during thyroid surgery is visual inspection of the physical condition of tissues, e.g., their color and bleeding edges. Another technique is measurement of intact parathyroid hormone. Recently, indocyanine green-enhanced fluorescence has been used in various surgical techniques, particularly laparoscopic surgery, to improve visualization and to provide detailed anatomical information. Fluorescent optical guidance helps surgeons to avoid inadvertent tissue injury while enhancing procedural efficiency. This technique has potential use for evaluating perfusion of the parathyroid gland in real-time intraoperative angiography.

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Section: Review Articlementioning

confidence: 99%

“…Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

Section: Icg-enhanced Fluorescence Imaging In Surgerymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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Indocyanine Green–Enhanced Fluorescence Optical Imaging in Patients With Early and Very Early Arthritis: A Comparative Study With Magnetic Resonance Imaging

Werner

Länger

Schøtt

et al. 2013

Arthritis & Rheumatism

102

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Objective. Indocyanine green-enhanced fluorescence optical imaging (FOI) is a novel diagnostic tool for the assessment of inflammation in arthritis. We undertook this study to compare FOI with magnetic resonance imaging (MRI) in 32 patients with early and very early untreated arthritis (mean disease duration 7.1 months).Methods. FOI images were acquired with the commercially available Xiralite system. Image interpretation was done for an early phase (phase 1), an intermediate phase (phase 2), and a late phase (phase 3), and for an electronically generated composite image. The results were compared with those of clinical examination (960 joints) and contrast (gadolinium)-enhanced 1.5T MRI (382 joints) of the clinically more affected hand. Additionally, we evaluated FOI in a control group of 46 subjects without any signs of inflammatory joint disease (1,380 joints).Results. With MRI as the reference method, the sensitivity of FOI was 86% and the specificity was 63%, while the composite image, phase 1, and phase 3 reached high specificities (87%, 90%, and 88%, respectively). The results differed considerably between the composite image and the phases. FOI did not detect inflammation in 11 joint regions that showed palmar tenosynovitis on MRI. Intrareader and interreader agreements were moderate to substantial ( ‫؍‬ 0.55-0.73). In the control group, FOI showed positive findings in 5% of normal joints in phase 2.Conclusion. Further multicenter studies will address the question of whether FOI allows sensitive and reliable detection of inflammatory changes in early arthritis, as suggested by our initial findings. If this is confirmed, FOI has the potential to be a sensitive and valuable tool for monitoring disease activity on site in clinical settings and for serving as an outcome parameter in clinical trials.

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Performance test methods for near‐infrared fluorescence imaging

et al. 2020

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Purpose: Near-infrared fluorescence (NIRF) imaging using exogenous contrast has gained much attention as a technique for enhancing visualization of vasculature using untargeted agents, as well as for the detection and localization of cancer with targeted agents. In order to address the emerging need for standardization of NIRF imaging technologies, it is necessary to identify the best practices suitable for objective, quantitative testing of key image quality characteristics. Toward the development of a battery of test methods that are rigorous yet applicable to a wide variety of devices, we have evaluated techniques for phantom design, measurement, and calculation of specific performance metrics. Methods: Using a NIRF imaging system for indocyanine green imaging, providing excitation at 780 nm and detection above 830 nm, we explored methods to evaluate uniformity, field of view, spectral crosstalk, spatial resolution, depth of field, sensitivity, linearity, and penetration depth. These measurements were performed using fluorophore-doped multiwell plate and high turbidity planar phantoms, as well as a 3D-printed multichannel phantom and a USAF 1951 resolution target. Results and Conclusions: Based on a wide range of approaches described in medical and fluorescence imaging literature, we have developed and demonstrated a cohesive battery of test methods for evaluation of fluorescence image quality in wide-field imagers. We also propose a number of key metrics that can facilitate direct, quantitative comparison of device performance. These methods have the potential to facilitate more uniform evaluation and inter-comparison of clinical and preclinical imaging systems than is typically achieved, with the long-term goal of establishing international standards for fluorescence image quality assessment.

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Sensitivity and depth penetration of continuous wave versus frequency-domain photon migration near-infrared fluorescence contrast-enhanced imaging

Cited by 18 publications

References 0 publications

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Indocyanine Green–Enhanced Fluorescence Optical Imaging in Patients With Early and Very Early Arthritis: A Comparative Study With Magnetic Resonance Imaging

Performance test methods for near‐infrared fluorescence imaging

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