Sensitivity Analysis of Interaction between the Left Ventricle and the Systemic Arteries

Development of systemic arterial mechanical properties from infancy to adulthood interpreted by four-element windkessel models

“…Recent studies by Stergiopulos et al (37,38), however, have demonstrated that the W3 model can produce realistic aortic pressures and flows, but only with parameter values of C and R c that overestimate and underestimate, respectively, the vascular properties. A four-element windkessel model (W4P), derived from the W3 model by introducing an inertial term (L) in parallel with R c (9,14,15,38), yielded an improvement of data fit and vascular parameter estimation in dogs and humans. The inertial term was given the hemodynamics meaning of total arterial inertance (38).…”