Employing natural or arti cial sunscreens is essential to protect the skin from ultraviolet radiations that cause premature aging and develop melanoma and other forms of skin cancer. The 2-Phenylbenzimidazole-5-sulfonic acid, commonly known as ensulizole is a water-soluble arti cial sunscreen that absorbs mostly UV-B (280 nm − 315 nm) radiations and protects the skin against the harmful effects of these radiations. Steady-state absorption indicates a strong absorption feature at 303 nm and a weak at 316 nm that have been identi ed as π → π* and n → π* transitions, respectively. The photoluminescence (PL) spectra indicate that the PL of ensulizole is less Stokes-shifted in polar solvents and more Stokes-shifted in non-polar solvents. The average PL lifetime of ensulizole is longer in non-polar solvents as compared to polar solvents and it exhibits the shortest PL lifetime in aqueous medium that signi es its e ciency in water. This suggests in non-polar solvents intersystem crossing is the dominant mode of relaxation of the excited ππ* state. Furthermore, an increase of pH of ensulizole solution decreases the PL intensity and the lifetime.Stern-Volmer equation is employed to evaluate bimolecular quenching rate constant k q that suggests the diffusional dynamic mode of PL quenching is operative.