Sensitive skin and transcutaneous penetration

Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome

“…The function of the Stratum corneum critically depends on proper differentiation of keratinocytes and a coordinated activity of acid, lipid and enzyme constituents. In AD, epidermal barrier dysfunction is consistently observed in affected and unaffected skin and evidenced by elevated markers of epidermal permeability including elevated transepidermal water loss (TEWL), [1] elevation of pH, [2] increased permeability, [3] reduced water retention [4,5] and enhanced susceptibility to infection. [6,7] At the molecular abundance, a reduced expression of epidermal structural proteins such as filaggrin, [8,9] imbalances in protease-protease inhibitor interactions, [10,11] a reduced expression of tight junction proteins [12,13] and an altered skin microbiome configuration [14] has been reported for both lesional and non-lesional skin.…”