Sensitive screening method for buprenorphine in urine

Hackett, L.P.; Dusci, L.J.; Ilett, K. F.; Seow, S.S.W.; Quigley, Allan

doi:10.1016/s0378-4347(00)83299-5

Cited by 27 publications

(5 citation statements)

References 5 publications

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“…The One-Step TM ELISA test proposed by IDS allows us to detect the low ng/mL or pg/mg range of buprenorphine generally observed in biological fluids [8][9][10] and human hair [11].…”

Section: Urinementioning

confidence: 99%

Evaluation of the One-Step™ ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens

Cirimele

Etienne

Villain

et al. 2004

Forensic Science International

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“…The One-Step TM ELISA test proposed by IDS allows us to detect the low ng/mL or pg/mg range of buprenorphine generally observed in biological fluids [8][9][10] and human hair [11].…”

Section: Urinementioning

confidence: 99%

Evaluation of the One-Step™ ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens

Cirimele

Etienne

Villain

et al. 2004

Forensic Science International

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“…Several analytical methods have been developed for quantitation of BUP in biological samples. Early analytical methods included quantitation of BUP by high‐performance liquid chromatography (HPLC) coupled to ultra‐violet (UV) (Hackett et al ., ), fluorescence detection (Ho et al ., ) or GC (Blom et al ., ). Several liquid chromatography coupled to mass spectrometry (LC–MS) methods have also been developed for analysis of BUP in whole blood (Hoja et al ., ), plasma (Ceccato et al ., ; Liu et al ., ; Moody et al ., ; Murphy and Huestis, ; Polettini and Huestis, ; Regina and Kharasch, ), serum (Scislowski et al ., ), urine (Fox et al ., ; Hegstad et al ., ; Kacinko et al ., ; Kronstrand et al ., ; Liu et al ., ; McMillin et al ., ; Regina and Kharasch ) and umbilical cord (Concheiro et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of buprenorphine, naloxone and their metabolites in rat plasma using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry

Joshi¹,

Parris²,

Liu

et al. 2016

Biomedical Chromatography

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A rapid and sensitive LC-MS/MS method was developed and validated for the simultaneous determination of buprenorphine and its three metabolites (buprenorphine glucuronide, norbuprenorphine and norbuprenorphine glucuronide) as well as naloxone and its metabolite naloxone glucuronide in the rat plasma. A hydrophilic interaction chromatography column and a mobile phase containing acetonitrile and ammonium formate buffer (pH 3.5) were used for the chromatographic separation. Mass spectrometric detection was achieved by an electrospray ionization source in the positive mode coupled to a triple quadrupole mass analyzer. The calibration curves for the six analytes displayed good linearity over the concentration range 1.0 or 5.0-1000 ng/mL. The intra and inter-day precision (CV) ranged from 2.68 to 16.4% and from 9.02 to 14.5%, respectively. The intra- and inter-day accuracy (bias) ranged from -14.2 to 15.2% and from -9.00 to 4.80%, respectively. The extraction recoveries for all the analytes ranged from 55 to 86.9%. The LC-MS/MS method was successfully applied to a pharmacokinetic study of buprenorphine-naloxone combination in rats.

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“…BU in biological samples analyzed mainly using chromatographic methods such as gas chromatography with electron-capture detector (Everhart et al, 1997), HPLC with UV detector (Tebbett et al, 1985;Hackett et al, 1986); fluorescence detector (Liu et al, 2005;Garrett et al, 1985); electrochemical detector (Garcia-Fernandez et al, 2001) and some hyphenated techniques like HPLC-MS (Polettini et al, 1997;Moody et al, 2002;Pirnay et al, 2006;Rodriguez-Ross et al, 2007). But, as these methods reported for analysis of biological samples, these involve sample preparation steps consisting of extraction and/or derivatization before analysis.…”

Section: Introductionmentioning

confidence: 99%

A Study of Method Development, Validation and Forced Degradation for Quantification of Buprenorphine Hydrochloride in a Microemulsion Formulation

Mundhey¹,

Rajkondawar²,

Daud³

et al. 2016

J App Pharm Sci

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. Results: The average retention time for buprenorphine was 14.319 min. The method was validated according to the ICH guidelines. The validation characteristics included accuracy, precision, linearity, range, specificity, limit of Quantitation and robustness. The calibration curves were linear (R 2 > 0.999) over the concentration range 1.0 -500.0 µgmL −1 for buprenorphine hydrochloride and recovery study for the compound was above 95 %. No spectral or chromatographic interferences from the microemulsion excipients were found. The drug was found to be labile under oxidative stress condition; whereas stable under all other stress conditions. Conclusion: This method is simple, rapid and suitable for routine quality control analysis.

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Sensitive screening method for buprenorphine in urine

Cited by 27 publications

References 5 publications

Evaluation of the One-Step™ ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens

Evaluation of the One-Step™ ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens

Quantitative determination of buprenorphine, naloxone and their metabolites in rat plasma using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry

A Study of Method Development, Validation and Forced Degradation for Quantification of Buprenorphine Hydrochloride in a Microemulsion Formulation

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