Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles
Lipeng Gao,
He-Li Zhang,
Xiao-Yang Tan
et al.
Abstract:Many people suffer from hair loss and abnormal skin pigmentation, highlighting the need for simple assays to support drug discovery research. Current assays have various limitations, such as being in vitro only, not sensitive enough, or unquantifiable. We took advantage of the bilateral symmetry and large size of mouse whisker follicles to develop a novel in vivo assay called “whisker follicle microinjection assay”. In this assay, we plucked mouse whiskers and then injected molecules directly into one side of … Show more
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