Sensitive multicolor visual detection of telomerase activity based on catalytic hairpin assembly and etching of Au nanorods

Wang, Danni; Guo, Rui; Wei, Yizhen; Zhang, Yingzhi; Zhao, Xiayu; Xu, Zhang-Run

doi:10.1016/j.bios.2018.09.064

Cited by 84 publications

(34 citation statements)

References 30 publications

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“…Colorimetric-based aptasensors have been used for the detection of disease biomarkers, due to their simplicity, ease of use, accessibility, and point-of-care detection ( 65 , 66 ). The colorimetric method is a promising technique due to the possibility of detection by simply visual color change ( 67 ).…”

Section: Optical Aptasensors In Early Cancer Detectionmentioning

confidence: 99%

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Zahra

Khan

2021

Front. Oncol.

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Cancer is a life-threatening concern worldwide. Sensitive and early-stage diagnostics of different cancer types can make it possible for patients to get through the best available treatment options to combat this menace. Among several new detection methods, aptamer-based biosensors (aptasensors) have recently shown promising results in terms of sensitivity, identification, or detection of either cancerous cells or the associated biomarkers. In this mini-review, we have summarized the most recent (2016–2020) developments in different approaches belonging to optical aptasensor technologies being widely employed for their simple operation, sensitivity, and early cancer diagnostics. Finally, we shed some light on limitations, advantages, and current challenges of aptasensors in clinical diagnostics, and we elaborated on some future perspectives.

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Section: Optical Aptasensors In Early Cancer Detectionmentioning

confidence: 99%

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Zahra

Khan

2021

Front. Oncol.

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“…Unmodified gold nanorods (AuNRs) of 50 nm length have been used for deoxyribonucleic acid (DNA) detection down to 1.47 nM with a colorimetric sensor [96]. Wang et al studied telomerase activity in as low as 15 HeLa cells using the AuNR (70 nm length in absence of HeLa cells) etching strategy [97]. Another group also reported a similar technique for the ultrasensitive detection of inorganic pyrophosphatase activity [98].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…One study developed by Wang et al that attracts great attention because of its simple, inexpensive, and ease-of-use performance is based on colorimetric assay monitoring of the telomerase activity [80]. This enzyme is repressed in mature somatic cells after birth, resulting in a shortening of the telomere after each cell division, but it is altered and reactivated in 85% of tumor cells, allowing uncontrolled cell proliferation [81,82].…”

Section: Localized Surface Plasmon Resonance (Lspr) Shift and Colorimmentioning

confidence: 99%

“…Plasmonic materials improve the detection of cancer biomarkers through several techniques: (A) Colorimetric assay is performed based on telomerase activity, proportional to the etching of Au nanorods. Adapted with permission from[80]. Copyright Elsevier 2019.…”

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confidence: 99%

Cancer Diagnosis through SERS and Other Related Techniques

Blanco-Formoso

Alvarez-Puebla

2020

IJMS

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Cancer heterogeneity increasingly requires ultrasensitive techniques that allow early diagnosis for personalized treatment. In addition, they should preferably be non-invasive tools that do not damage surrounding tissues or contribute to body toxicity. In this context, liquid biopsy of biological samples such as urine, blood, or saliva represents an ideal approximation of what is happening in real time in the affected tissues. Plasmonic nanoparticles are emerging as an alternative or complement to current diagnostic techniques, being able to detect and quantify novel biomarkers such as specific peptides and proteins, microRNA, circulating tumor DNA and cells, and exosomes. Here, we review the latest ideas focusing on the use of plasmonic nanoparticles in coded and label-free surface-enhanced Raman scattering (SERS) spectroscopy. Moreover, surface plasmon resonance (SPR) spectroscopy, colorimetric assays, dynamic light scattering (DLS) spectroscopy, mass spectrometry or total internal reflection fluorescence (TIRF) microscopy among others are briefly examined in order to highlight the potential and versatility of plasmonics.

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Sensitive multicolor visual detection of telomerase activity based on catalytic hairpin assembly and etching of Au nanorods

Cited by 84 publications

References 30 publications

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Advances in Optical Aptasensors for Early Detection and Diagnosis of Various Cancer Types

Recent Progress in Optical Sensors for Biomedical Diagnostics

Cancer Diagnosis through SERS and Other Related Techniques

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