Sensitive molecular binding assay using a photonic crystal structure in total internal reflection

Guo, Yunbo; Divin, Charles J.; Myc, Andrzej; Terry, Fred L.; Baker, James R.; Norris, Theodore B.; Ye, Jing Yong

doi:10.1364/oe.16.011741

Cited by 61 publications

(51 citation statements)

References 26 publications

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“…There are different known approaches to synthesize undoped LiNbO3 nanocrystals using soft-chemistry [15], pulsed laser deposition [16,17], RF sputtering [18] and hydrothermal methods [19,20]. LiNbO3 is also studied in its heterojunction structure, photonic crystal and single phase thin film [21][22][23][24][25], and surface acoustic wave device (SAW) [26]. LiNbO3 waveguides are employed broadly in many functional electro-optic and acoustooptic devices [27].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Lithium Niobate nanophotonic structures via spin-coating technique for optical waveguides application

et al. 2017

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Abstract. This work is dedicated to investigation of temperature effects in Lithium Niobate (LiNbO3) nanostructures. The LiNbO3 nanostructures were deposited on glass substrate by spincoating technique. LiNbO3 was set down at 3000 rpm for 30 sec and annealed from 100 to 600 o C. The structures were characterized and analyzed by scanning electron microscopy (SEM) and ultraviolet visible (UV-vis) spectrophotometer. The measured results have showed that by increasing annealing temperatures, the structures start to be more crystallized and be more homogenized until the optimum arrangement was achieved. Once this was accomplished, it's applicable for optical waveguides development. Eventually, it starts to be less crystallization and non-homogeneous. Energy gap was recorded to be at average value of 3.9 eV.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Lithium Niobate nanophotonic structures via spin-coating technique for optical waveguides application

et al. 2017

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“…Where nj is the refractive index of higher index layer or lower index layer, dj is the corresponding physical thickness, șj is the corresponding refraction angle, ȜR is the resonant wavelength [11]. Present the concept of impedance is applied in the PC layers to fabricate the 1D PC structure [8].…”

Section: Introductionmentioning

confidence: 99%

Characteristic Optimization of Multilayer Dielectric for the Bloch-Surface-Wave Based Sensor

Liu

Zhang

et al. 2013

2013 IEEE International Conference on Green Computing and Communications and IEEE Internet of Things and IEEE Cyber, Physical A

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“…18,19 This PC-TIR sensor (a PC structure used in TIR geometry) has a number of advantages. First, a variety of materials can be used for the cavity layer, because no coating is necessary on top of the cavity layer.…”

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confidence: 99%

“…For a PC-TIR sensor operating near the resonant condition, the maximum optical sensitivity is given by 18 O…”

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confidence: 99%

Broadband optical ultrasound sensor with a unique open-cavity structure

et al. 2011

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Abstract. High-resolution ultrasound imaging requires quality sensors with wide bandwidth and high sensitivity, as shown in a wide range of applications, including intravascular imaging of cardiovascular diseases. However, piezoelectric technology, the current dominant approach for hydrophone fabrication, has encountered many technical limitations in the high-frequency range. Using optical techniques for the detection of high-frequency ultrasound signals has attracted much recent attention. One of the most studied approaches is based on a Fabry-Pérot interferometer, consisting of an optical cavity sandwiched between two mirrors. This technique offers promising sensitivity and bandwidth, and a potential alternative to piezoelectric polyvinylidene fluoride (PVDF) hydrophones. We propose an innovative optical ultrasound sensor using only a single mirror in a total-internal-reflection configuration. Besides retaining the advantages of Fabry-Pérot interferometer-based ultrasound sensors, this unique design provides a bandwidth of at least 160 MHz, a potential decrease in fabrication cost, and an increase in signal fidelity. There is a pervasive demand for high-resolution imaging techniques for comprehensive morphological and functional imaging of critical biological organs covered by thick tissue layers. Optical microscopy normally provides superior resolution but with shallow imaging depth in scattering media. In contrast, acoustic imaging enables deep tissue imaging but with relatively low spatial resolution, restricted by the frequency range employed in conventional diagnostic ultrasound imaging. In principle, ultrasound imaging resolution can be improved by using higher frequencies (e.g., 50 MHz). However, for a conventional piezoelectric-based ultrasound sensor, higher operation frequency demands smaller effective sensor size, 1 which imposes several technological difficulties in the fabrication of miniature piezoelectric ultrasound sensors. The challenges include dicing piezoceramics to micrometer-size elements, 2 making electrical connections to the small elements, cross talk between elements, and increased detection noise due to reduced element size.3 Although recently developed miniature polyvinylidene fluoride (PVDF) membrane hydrophones can potentially achieve 4, 5 a frequency bandwidth beyond 140 MHz, demanding electrical connections and cross talk persist if these membrane hydrophones are intended for imaging arrays. Furthermore, it has been reported that the noise-equivalent pressure (NEP) of a 50-μm-diam Fabry-Pérot optical ultrasound sensor is comparable to that of 1-mm-diam PVDF membrane hydrophone. 6 Given that the sensitivity of a membrane hydrophone decreases as its area becomes smaller due to lower capacitance, 7 the Fabry-Pérot ultrasound sensor can potentially outperform the PVDF membrane sensor with the same active area. 8As discussed in recent publications, 3,6,[8][9][10][11][12][13][14][15][16] optical ultrasound sensors have the potential to overcome many of the challenges just mentioned. F...

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Sensitive molecular binding assay using a photonic crystal structure in total internal reflection

Cited by 61 publications

References 26 publications

Enhancement of Lithium Niobate nanophotonic structures via spin-coating technique for optical waveguides application

Enhancement of Lithium Niobate nanophotonic structures via spin-coating technique for optical waveguides application

Characteristic Optimization of Multilayer Dielectric for the Bloch-Surface-Wave Based Sensor

Broadband optical ultrasound sensor with a unique open-cavity structure

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