“…Rifampicin can, however, be reliably demonstrated in the urine for at least 12 h using a simple plate diffusion test with Staphylococcus aureus,61 while an alternative microbiological procedure of far greater sensitivity has also been described. 62 No method has as yet been described for monitoring the ingestion of c1ofazimine. Among light-skinned patients the degree of skin pigmentation may provide an indication of the extent to which the drug is being taken, but it is in just such patientS' that the c10fazimine is likely to be least acceptable.…”