Sensitive method for nontransferrin-bound iron quantification by graphite furnace atomic absorption spectrometry

Jakeman, Anthony J.; Thompson, T.S.; McHattie, James D.; Lehotay, Denis C.

doi:10.1016/s0009-9120(00)00194-6

Cited by 24 publications

(13 citation statements)

References 10 publications

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“…Furthermore, a recent study demonstrated a direct correlation between NTBI and vital organ damage in thalassemia patients [45] . In a normal individual, there is no detectable NTBI [46] ; on the other hand, hemochromatosis patients exhibit higher NTBI levels than controls [47] . The growing evidence on NTBI suggests that it could be a good index of iron overload in TM patients.…”

Section: Non-transferrin-bound Ironmentioning

confidence: 93%

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Koonrungsesomboon

Chattipakorn²,

Fucharoen³

et al. 2013

WJC

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Myocardial siderosis is known as the major cause of death in thalassemia major (TM) patients since it can lead to iron overload cardiomyopathy. Although this condition can be prevented if timely effective intensive chelation is given to patients, the mortality rate of iron overload cardiomyopathy still remains high due to late detection of this condition. Various direct and indirect methods of iron assessment, including serum ferritin level, echocardiogram, non-transferrin-bound iron, cardiac magnetic resonance T2*, heart rate variability, and liver biopsy and myocardial biopsy, have been pro- REVIEW 270August 26, 2013|Volume 5|Issue 8|

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Section: Non-transferrin-bound Ironmentioning

confidence: 93%

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Koonrungsesomboon

Chattipakorn²,

Fucharoen³

et al. 2013

WJC

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“…35,47 Non-transferrin-bound iron (NTBI) seems to be the most accurate parameter among serum iron markers; however, it is commonly used only in research studies. [48][49][50][51][52][53] Accurate assessments of cardiac dysfunction and/or cardiac iron status are currently based on imaging techniques. The T2-star magnetic resonance imaging (MRI-T2*) has been demonstrated as evaluating cardiac iron status accurately and allows the early detection of global ventricular dysfunction.…”

Section: Cardiac Complications In Beta-thalassemia Patientsmentioning

confidence: 99%

Cardiac complications in beta-thalassemia: From mice to men

Kumfu

Fucharoen

Chattipakorn

2017

Exp Biol Med (Maywood)

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Iron overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. Since investigation of iron overload cardiomyopathy in thalassemia patients has many limitations, a search for an animal model for this condition has been ongoing for decades. In the past decades, there is no doubt that the use of b-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects of iron overload on the hearts of b-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. AbstractBeta-thalassemia is an inherited hemoglobin disorder caused by reduced or absent synthesis of the beta globin chains of hemoglobin. This results in variable outcomes ranging from clinically asymptomatic to severe anemia, which then typically requires regular blood transfusion. These regular blood transfusions can result in an iron overload condition. The iron overload condition can lead to iron accumulation in various organs, especially in the heart, leading to iron overload cardiomyopathy, which is the major cause of mortality in patients with thalassemia. In the past decades, there is no doubt that the use of b-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects that iron overload has on the hearts of b-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. The in-depth understanding of biomolecular alterations in the heart of these iron overload thalassemic mice will help give guidance for more effective therapeutic approaches in the near future.

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“…Currently, however, it is commonly used only in research studies. Various methods and protocols used in the determination of NTBI have been proposed, but no consensus has been established (28)(29)(30)(31)(32).…”

Section: Assessment and Markers Of Cardiac Iron Statusmentioning

confidence: 99%

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Lekawanvijit

Chattipakorn

2009

Canadian Journal of Cardiology

106

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Sensitive method for nontransferrin-bound iron quantification by graphite furnace atomic absorption spectrometry

Cited by 24 publications

References 10 publications

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Cardiac complications in beta-thalassemia: From mice to men

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

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