Sensitive low‐pressure dielectric barrier discharge ion source

Sugiyama, Megumi; Kumano, Shun; Nishimura, Katsumi; Hasegawa, Hideki; Hashimoto, Yuichiro

doi:10.1002/rcm.6546

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…We previously developed a highly sensitive ionization source, the LP-DBDI source, whose optimum pressure is around several thousand Pa . It is shown schematically in Figure C.…”

Section: Resultsmentioning

confidence: 99%

“…21 With a commercial mass spectrometer (DS1000, Hitachi, Ltd., Tokyo, Japan), we confirmed that a ■ RESULTS AND DISCUSSION Discontinous Sample Gas Introduction and Low-Pressure Dielectric Barrier Discharge. We previously developed a highly sensitive ionization source, the LP-DBDI source, whose optimum pressure is around several thousand Pa. 18 It is shown schematically in Figure 1C. Even when an ion trap was used for the mass analyzer, the pressure of the chamber in which the ion trap was located had to be around 0.1 Pa to obtain unit mass resolution.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…We have made a highly sensitive portable mass spectrometer using novel techniques different from those described above. We previously developed a highly sensitive ionization source, a low-pressure dielectric barrier discharge ionization (LP-DBDI) source, differing from the glow discharge ionization source . The LP-DBDI requires one or more dielectric barriers and is operated using AC voltage .…”

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confidence: 99%

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Development of a Portable Mass Spectrometer Characterized by Discontinuous Sample Gas Introduction, a Low-Pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique

et al. 2013

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The present study has attempted to downscale a mass spectrometer in order to make it portable and enable onsite analysis with it. The development of a small mass spectrometer required the use of a compact pump whose displacement was small, decreasing the sensitivity of that spectrometer. To get high sensitivity with a small mass spectrometer, we have integrated novel techniques: a highly sensitive ionization source and efficient extraction of sample vapor. The low-pressure dielectric barrier discharge ionization (LP-DBDI) source made it possible to increase the conductance between the source and the mass analyzer, compared with ambient ionization sources, enhancing the efficiency of the ion transfer from the ionization source to the mass analyzer. We have also developed a vacuumed headspace method efficiently transporting the sample vapor to the ionization source. The sensitivity was further enhanced by also using a discontinuous sample gas introduction technique. A prototype portable mass spectrometer using those novel techniques was found to be sensitive enough to detect 0.1 ppm methamphetamine, 1 ppm amphetamine, 1 ppm 3,4-methylenedioxymethamphetamine, and 10 ppm cocaine in liquid.

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“…We previously developed a highly sensitive ionization source, the LP-DBDI source, whose optimum pressure is around several thousand Pa . It is shown schematically in Figure C.…”

Section: Resultsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

mentioning

confidence: 99%

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Development of a Portable Mass Spectrometer Characterized by Discontinuous Sample Gas Introduction, a Low-Pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique

et al. 2013

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“…In contrast, the discharge sources like glow or barrier discharge are more easily stabilized under reduced pressure. 33,34) Due to the high surface tension of water (0.073 N/m), spraying of pure aqueous solution is known to have higher ESI onset voltage compared to organic solvent mixtures (e.g. 50 v/v% methanol/water solution).…”

Section: Electrospray Under Super-atmospher Ic Pressure Esi and Dischmentioning

confidence: 99%

When API Mass Spectrometry Meets Super Atmospheric Pressure Ion Sources

Chen

2015

Mass Spectrometry

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“…Our group developed a prototype of a portable mass spectrometer for use in the screening of illicit drugs as an alternative to an immunoassay kit. 18,19) It uses a highly sensitive ionization source, a low-pressure dielectric barrier discharge ionization (LP-DBDI) source. A discontinuous sample gas introduction technique and a vacuum headspace method are used to e ciently transport the sample vapor to the LP-DBDI source.…”

Section: Introductionmentioning

confidence: 99%

Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer

et al. 2015

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We previously reported on the development of a portable mass spectrometer for the onsite screening of illicit drugs, but our previous sampling system could only be used for liquid samples. In this study, we report on an attempt to develop a probe heating method that also permits solid samples to be analyzed using a portable mass spectrometer. An aluminum rod is used as the sampling probe. The powdered sample is affixed to the sampling probe or a droplet of sample solution is placed on the tip of the probe and dried. The probe is then placed on a heater to vaporize the sample. The vapor is then introduced into the portable mass spectrometer and analyzed. With the heater temperature set to 130°C, the developed system detected 1 ng of methamphetamine, 1 ng of amphetamine, 3 ng of 3,4-methylenedioxymethamphetamine, 1 ng of 3,4-methylenedioxyamphetamine, and 0.3 ng of cocaine. Even from mixtures consisting of clove powder and methamphetamine powder, methamphetamine ions were detected by tandem mass spectrometry. The developed probe heating method provides a simple method for the analysis of solid samples. A portable mass spectrometer incorporating this method would thus be useful for the onsite screening of illicit drugs.

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Sensitive low‐pressure dielectric barrier discharge ion source

Abstract: LP-DBDI is a soft ionization method characterized by only minor fragmentation, similar to APCI. The sensitivity of the LP-DBDI source was found to be about 40 times higher than that of the conventional APCI source.

Cited by 8 publications

References 25 publications

Development of a Portable Mass Spectrometer Characterized by Discontinuous Sample Gas Introduction, a Low-Pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique

Development of a Portable Mass Spectrometer Characterized by Discontinuous Sample Gas Introduction, a Low-Pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique

When API Mass Spectrometry Meets Super Atmospheric Pressure Ion Sources

Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer

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