Sensitive Logic Nanodevices with Strong Response for Weak Inputs

Abstract

Sensitive sensing is critical when developing new calculation systems with weak input signals (ISs). In this work, a "weak-inputs-strong-outputs" strategy was proposed to guide the construction of sensitive logic nanodevices by coupling an input-induced reversible DNA computing platform with a hybridization chain reaction-based signal amplifier. By rational design of the sequence of computing elements (CEs) so as to avoid cross-talking between ISs and signal amplifier, the newly formed logic nanodevices have good sensitivity to the weak ISs even at low concentrations of CEs, and are able to perform YES, OR, NAND, NOR, INHIBIT, INHIBIT-OR and number classifier operation, showing that the DNA calculation proceeds in dilute solution medium that greatly improves the calculation proficiency of logic nanodevices without the confinement of the lithography process in nanotechnology.

Logic-Gates of Gas Pressure for Portable, Intelligent and Multiple Analysis of Metal Ions

“…In the past few years, fluorescent, , electrochemical, colorimetric, , and surface-enhanced Raman spectroscopy signals were employed as outputs in reported DNA logic gates. These assays were significant advances in logic gate-based intelligent diagnosis.…”

Dual-Mode Logic Gate for Intelligent and Portable Detection of MicroRNA Based on Gas Pressure and Lateral Flow Assay

“…This characteristic satisfies the crucial need for an optimal “fast-screening” diagnostic tool, which holds great significance and promise in intelligent biosensing. To date, fluorescent, electrochemical, colorimetric, and other kinds of DNA logic gates were fabricated to detect multiple analytes simultaneously, which further simplifies the analysis procedures and enhances the accuracy. − These methods are efficient, but most of them require laboratory-based instruments, which may restrict their use for portable and intelligent detection of multiple analytes. Therefore, it is crucial to develop simple and affordable logic operations for detection of biomarkers.…”

Temporal logic circuits implementation using a dual cross-inhibition mechanism based on DNA strand displacement

“…DNA nanotechnology has brought forth novel methods and techniques for computation and manufacturing at the molecular and nanoscale levels. 1,2 DNA molecules, harnessed in ways unseen in nature, are employed to fabricate chemical reaction networks, 3,4 molecular computers, 5,6 information storage media, 7,8 and further utilized to drive nanomachines, 9,10 control molecular systems, 11,12 process information, 13,14 and construct molecular security systems. 15,16 Among all applications, DNA circuits play a vital role, which can be realized through diverse approaches including DNA strand displacement, 17,18 pH-regulation, 19,20 lighting control, 21,22 DNA self-assembly, 23,24 and more.…”