Sensitive liquid chromatography–tandem mass spectrometry method for the simultaneous determination of paracetamol and guaifenesin in human plasma

Chen, Xiaoyan; Huang, Jianguo; Zhang, Kong; Zhong, Dafang

doi:10.1016/j.jchromb.2004.12.011

Cited by 53 publications

(27 citation statements)

References 16 publications

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“…1, 2), compete with each other in the dry reforming and determine the carbon deposition level. In principle, the methane decomposition is thermodynamically favourable in dry reforming and is responsible for carbon formation at low temperature, while the carbon gasification is thermodynamically unfavourable which can be realised in high concentration of CO 2 or applying higher temperature to shift the carbon diminishing reaction [26]. It has been acknowledged that the fluidization of the catalyst particles offers them alternative environments of rich-CO 2 and lean-CO 2 , where the CO 2 -rich zones would facilitate removal of deposited carbon on Ni/Al2O3 [15].…”

Section: Analysis Of the Catalyst Deactivationmentioning

confidence: 99%

Comparative study of the dry reforming of methane on fluidised aerogel and xerogel Ni/Al2O3 catalysts

2013

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The xerogel and aerogel Ni(20 wt %)/Al 2 O 3 catalysts were prepared through incipient-wetnessimpregnation and co-precipitation-supercritical drying (CP-SCD), respectively. All the fresh and used catalysts were well characterised using FESEM, BET, XRD, H 2 -TPR and H 2 -TPD techniques. Their properties and catalytic performance in dry reforming of CH 4 in a fluidised bed reactor were comparatively investigated. In comparison with the xerogel catalyst, the aerogel catalyst possessed smaller crystallite size of nickel, larger specific surface area, higher nickel dispersion, lower bulky density and better fluidization quality. More importantly, the aerosol catalyst showed higher catalytic activity, stability and less carbon deposition in dry reforming, due to the excellent physicochemical properties of the aerogel catalyst and its enhanced fluidization quality.

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Section: Analysis Of the Catalyst Deactivationmentioning

confidence: 99%

Comparative study of the dry reforming of methane on fluidised aerogel and xerogel Ni/Al2O3 catalysts

2013

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“…Although its safe characteristics, recent studies reported humans and experimental animals exposed to high dose of acetaminophen were associated with hepatic toxicity and renal failure. 1,2 This shows the importance on tablet composition and uniformity of active compounds in pharmaceutical products.…”

Section: Acetaminophen (Paracetamol N-acetyl-p-amino-phenol)mentioning

confidence: 99%

“…8 Among these techniques, LC with either DAD or MS applications is widely accepted for separating the active compounds in pharmaceutical products [9][10][11] or biological samples. 2,12 An isotope dilution mass spectrometry (IDMS) connecting chromatography is recently believed as one of the high accurate analytical techniques. An ID-LC/MS method is necessary to spike the stable isotope into the sample, to separate the analyte and isotopic compounds from the sample matrix on the LC column and to measure isotope ratio through determination of chromatographic areas for analyte and isotopic compounds.…”

Section: Acetaminophen (Paracetamol N-acetyl-p-amino-phenol)mentioning

confidence: 99%

Development of an Isotope-Dilution Liquid Chromatography/Mass Spectrometric Method for the Accurate Determination of Acetaminophen in Tablets

Shin¹,

Kim²,

Lee³

et al. 2010

Bulletin of the Korean Chemical Society

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“…In the literature survey, there were several LC assay methods that have been reported for the determination of GN and DN in pharmaceutical preparation either individually or in combination with other drugs [12][13][14][15][16][17][18][19][20] and in human plasma by LC-MS [21,22]. Few methods were available for the determination of impurities individually for GN and DN [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations

Raghavaraju

Kumar

et al. 2013

Chromatography Research International

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A sensitive, stability-indicating gradient RP-HPLC method has been developed for the simultaneous estimation of impurities of Guaifenesin and Dextromethorphan in pharmaceutical formulations. Efficient chromatographic separation was achieved on a Sunfire C18, 250 × 4.6 mm, 5 m column with mobile phase containing a gradient mixture of solvents A and B. The flow rate of the mobile phase was 0.8 mL min −1 with column temperature of 50 ∘ C and detection wavelength at 224 nm. Regression analysis showed an r value (correlation coefficient) greater than 0.999 for Guaifenesin, Dextromethorphan, and their impurities. Guaifenesin and Dextromethorphan formulation sample was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal, and photolytic degradation. Guaifenesin was found stable and Dextromethorphan was found to degrade significantly in peroxide stress condition. The degradation products were well resolved from Guaifenesin, Dextromethorphan, and their impurities. The peak purity test results confirmed that the Guaifenesin and Dextromethorphan peak was homogenous and pure in all stress samples and the mass balance was found to be more than 98%, thus proving the stability-indicating power of the method. The developed method was validated according to ICH guidelines with respect to specificity, linearity, limits of detection and quantification, accuracy, precision, and robustness.

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Sensitive liquid chromatography–tandem mass spectrometry method for the simultaneous determination of paracetamol and guaifenesin in human plasma

Cited by 53 publications

References 16 publications

Comparative study of the dry reforming of methane on fluidised aerogel and xerogel Ni/Al2O3 catalysts

Comparative study of the dry reforming of methane on fluidised aerogel and xerogel Ni/Al2O3 catalysts

Development of an Isotope-Dilution Liquid Chromatography/Mass Spectrometric Method for the Accurate Determination of Acetaminophen in Tablets

Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations

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