Sensitive Lc Method for Simultaneous Determination of Ciclesonide and Formoterol Fumarate in Dry Powder Inhaler

Patil, Ashish Tanaji; Patil, Sachin D.; Shaikh, Kabeer A.

doi:10.1080/10826076.2011.575980

Cited by 9 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Until now, a few analytical approaches such as gas chromatography 9 , liquid chromatography-mass spectrometry 10 , thin-layer chromatography, high-performance liquid chromatography (HPLC) 11 , ion-pair chromatography (IPC) 12 , spectrophotometry 13 , reversed-phase high performance liquid chromatography (RP-HPLC) 14 , and capillary electrophoresis 15 have been reported in the literature for the detection of FLFT in commercial and pharmacological samples. Nonetheless, these approaches have some drawbacks such as costly instrumentation, lengthy and time-consuming experimental procedures, and need pre-treatment, solvent extraction, and complex instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Electro-oxidation of formoterol fumarate on the surface of novel poly(thiazole yellow-G) layered multi-walled carbon nanotube paste electrode

Hareesha

Manjunatha

2021

Sci Rep

View full text Add to dashboard Cite

The current study explicates the electro-oxidation behavior of formoterol fumarate (FLFT) in the presence of uric acid (UA) on the surface of poly thiazole yellow-G (TY-G) layered multi-walled carbon nanotube paste electrode (MWCNTPE). The modified (Poly(TY-G)LMWCNTPE) and unmodified (MWCNTPE) electrode materials were characterized through electrochemical impedance spectroscopy (EIS), field emission scanning electron microscopy (FE-SEM), and cyclic voltammetry (CV) approaches. The characterization data confirms the good conducting and electrocatalytic nature with more electrochemical active sites on the Poly(TY-G)LMWCNTPE than MWCNTPE towards the FLFT analysis in the presence of UA. Poly(TY-G)LMWCNTPE easily separates the two drugs (FLFT and UA) even though they both have nearer oxidation peak potential. The electro-catalytic activity of the developed electrode is fast and clear for FLFT electro-oxidation in 0.2 M phosphate buffer (PB) of pH 6.5. The Poly(TY-G)LMWCNTPE offered a well-resolved peak with the highest electro-oxidation peak current at the peak potential of 0.538 V than MWCNTPE. The potential scan rate and oxidation peak growth time studies show the electrode reaction towards FLFT electro-oxidation is continued through a diffusion-controlled step. The variation of concentration of FLFT in the range from 0.2 to 1.5 µM (absence of UA) and 3.0 to 8.0 μM (presence of UA) provides a good linear relationship with increased peak current and a lower limit of detection (LOD) values of 0.0128 µM and 0.0129 µM, respectively. The prepared electrode gives a fine recovery for the detection of FLFT in the medicinal sample with acceptable repeatability, stability, and reproducibility.

show abstract

Section: Introductionmentioning

confidence: 99%

Electro-oxidation of formoterol fumarate on the surface of novel poly(thiazole yellow-G) layered multi-walled carbon nanotube paste electrode

Hareesha

Manjunatha

2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14][15][16][17][18][19][20][21] The estimation of FRF alone and in combination (mixture) with other active drug moiety including HPLC, GC and UV spectrophotometry has stated in published paper. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] The advancement of planar chromatography i.e., HPTLC has been arose as a chief tool in drug investigation and simplest of all the chromatographic techniques. HPTLC, a separation technique is flexible and rapid for quantitatively evaluation of extensive range of samples.…”

Section: Introductionmentioning

confidence: 99%

Synchronized Quantitative Assessment of Corticosteroid and Bronchodilator in Rotacaps by HPTLC using Fractional Factorial Design

Zanwar¹,

Sen²,

Pandya³

et al. 2021

IJPER

View full text Add to dashboard Cite

Background: A validated high performance planar chromatographic analysis for a combination medication of corticosteroids mometasone furoate and bronchodilators formoterol fumarate available as Evocort®: inhaler in market was developed. It is used for treating asthma, a reversible obstructive airways disease. Materials and Methods: The HPTLC chromatographic condition was optimised using aluminium sheets formerly coated with silica gel 60F 254 as stationary phase and toluene: methyl alcohol: methanoic acid (12.5:4:0.3 v/v/v) as mobile phase. Results: Formoterol fumarate and mometasone furoate concentration was found to be directly proportional to peak area in the range of 120-720 ng/band and 3996-23976 ng/band, respectively. Results of precision studies were between 0.77-1.274 stated in %RSD and recovery studies ranged from 99-101% indicating very low inter day variability and good reproducibility of the method. Fractional factor design was applied to five factors i.e. volume of mobile phase, amount of methyl alcohol in mobile phase, chamber saturation time, development distance, time from chromatography to scanning to study its effect on retardation factor and peak area of both the drug. Conclusion: The 3D response surface graphs exposed that ratio of methyl alcohol in the mobile phase was slightly rigorous factors affecting the responses. The compatibility of linearity ranges with ratio in their combined rotacaps and also nonappearance of excipients interference recommends application of the proposed methods in quality control analysis of cited drugs in commercial rotacaps.

show abstract

“…Literature survey for FFD and FP revealed that various analytical methods using techniques such as high-performance liquid chromatography [9][10][11][12][13][14][15][16][17][18][19][20], spectrophotometry [18,[21][22][23][24][25], and highperformance thin-layer chromatography (HPTLC) [19,26] were reported for quantitative determination of single or multi-component systems. Gowekar and Wadher reported HPTLC method for simultaneous estimation of FFD and FP, but no degradation profile has been stated in the literature [27].…”

Section: Introductionmentioning

confidence: 99%

Stability-Indicating High-Performance Thin-Layer Chromatography Method for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate in Bulk Drug and Pharmaceutical Dosage Form

Pharate

Dhaneshwar

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of the present work was to develop validated stability-indicating high-performance thin-layer chromatographic method for simultaneous estimation of formoterol fumarate dihydrate (FFD) and fluticasone propionate (FP) in bulk drug and pharmaceutical dosage form. Methods: Pre-coated silica gel aluminum plates 60 F-254 were used as stationary phase. The mixture of toluene:ethyl acetate:formic acid (98%) (6:4:0.1; v/v/v) was used as a mobile phase. The densitometric quantification was carried out at 233 nm. The method was validated according to the ICH guidelines. The specificity and stability indicating the capability of the method were proven though degradation studies. Both drugs were subjected to acid (0.1N HCl) and base (0.1N NaOH) hydrolysis, oxidation (3% v/v H2O2), photolytic, and neutral degradation conditions. Results: The selected mobile phase resolved peaks of FFD and FP with Rf values 0.27±0.10 and 0.64±0.10, respectively. Determination coefficients of calibration curves were found to be 0.998 and 0.999 in the range of 1–3.5 μg/spot and 10–60 μg/spot for FFD and FP with an accuracy of 99.09% for FFD and 99.20% for FP. The degradation products of FFD and FP were resolved from the pure drug with significant differences in their retention factor values. Conclusion: The developed method is simple, accurate and can be successfully applied for quantification of FFD and FP in bulk drug and pharmaceutical dosage form, contributing to improve the quality control and assure the therapeutic efficacy.

show abstract

Sensitive Lc Method for Simultaneous Determination of Ciclesonide and Formoterol Fumarate in Dry Powder Inhaler

Cited by 9 publications

References 10 publications

Electro-oxidation of formoterol fumarate on the surface of novel poly(thiazole yellow-G) layered multi-walled carbon nanotube paste electrode

Electro-oxidation of formoterol fumarate on the surface of novel poly(thiazole yellow-G) layered multi-walled carbon nanotube paste electrode

Synchronized Quantitative Assessment of Corticosteroid and Bronchodilator in Rotacaps by HPTLC using Fractional Factorial Design

Stability-Indicating High-Performance Thin-Layer Chromatography Method for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate in Bulk Drug and Pharmaceutical Dosage Form

Contact Info

Product

Resources

About