Sensitive HPLC–fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac

Wada, Mitsuhiro; Yokota, Chiaki; Ogata, Yasuhiro; Kuroda, Naotaka; Yamada, Hideyuki; Nakashima, Kenichiro

doi:10.1007/s00216-008-2070-4

Cited by 16 publications

(9 citation statements)

References 26 publications

(40 reference statements)

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“…The in vivo recoveries of the dialysis probe (R in vitro ) were calculated from four replicate measurements of in vitro recoveries (R in vitro ), in vitro losses (L in vitro ), and in vivo losses (L in vivo ), according to previous reports (Sun et al, 2002;Wada et al, 2008 …”

Section: In Vivo Brain Microdialysismentioning

confidence: 99%

Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain

Ikeda

Igari

Fuchigami

et al. 2011

European Journal of Pharmacology

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Baseline levels of dopamine and 5-HT in the striatum were 16.5±7.7 and 3.5±1.7 nM (mean ± standard deviation), respectively. After a single administration of MDMA (10 mg/kg, i.p.), a dramatic increase in extracellular dopamine (C max : 36.1-fold vs. baseline) and 5-HT levels (C max : 9.3-fold vs. baseline) was observed. When rats were co-administered with methamphetamine (1, 5 or 10 mg/kg) with MDMA, the dopamine levels induced by MDMA increased in a methamphetamine-dose-dependent manner (C max : 2.5-, 3.5-, and 3.8-fold vs. MDMA). A similar trend was observed in 5-HT levels (C max : 1.1-, 1.3-, and 1.8-fold vs. MDMA). In contrast, ketamine and caffeine showed synergistic effects on the monoamine levels induced by MDMA, whereas the individual administration of either of these compounds did not affect monoamine levels. Ketamine (1, 5 mg/kg) decreased the dopamine levels induced by MDMA (C max : 0.9-and 0.7-fold vs. MDMA) and increased the 5-HT levels induced by MDMA (C max : 1.4-and 1.6-fold vs. MDMA), and co-administration of caffeine (20 2 mg/kg) with MDMA increased dopamine levels (C max : 1.7-fold vs. MDMA). These results suggest that exposure to multiple drugs in addition to MDMA can have neurotoxic effects. 249 words

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Section: In Vivo Brain Microdialysismentioning

confidence: 99%

Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain

Ikeda

Igari

Fuchigami

et al. 2011

European Journal of Pharmacology

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“…In our study, the combination of HPLC separation with fluorescence detection using our original labeling reagent (DIBCl) and microdialysis sampling were used for estimation for drug-drug interactions of abusable drugs. 58,[70][71][72] MDMA tablets often contain other active components having hallucinogenic and/or stimulant effect such as caffeine, ketamine, ephedrine or methamphetamine. After administration of MDMA (5 mg/kg, i.p.)…”

Section: ·2 Evaluation Of Drug-drug Interaction Potential Formentioning

confidence: 99%

“…These results suggested that the clinical benefit of combined use of Mor and Dic might be caused by synergism of their different pharmacodynamic effects and/or by pharmacokinetic effects of Mor glucuronide. 58 Appetite suppressants have been used as Phen-Fen combinations; however, such use was found to enhance weight loss at lower doses as well as the neurotoxic effect. The profiles of pharmacokinetic parameters of Phen in rats, both blood and brain, following Phen (1 or 5 mg/kg) in the absence or presence of Fen (1 or 5 mg/kg) were significantly altered.…”

Section: ·2 Evaluation Of Drug-drug Interaction Potential Formentioning

confidence: 99%

Analytical Studies on the Development of High-Performance Liquid Chromatographic Methods with Fluorescence or Chemiluminescence Detections and Their Practical Applications

2009

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This review describes a comprehensive investigation focusing on syntheses of analytical reagents, followed by their utilization in development of analytical methods, and leading to practical applications for rational use of medicaments centering on abused drugs. Many kinds of analytical reagents for fluorescence and chemiluminescence detections have been synthesized with the intention of improving sensitivity. By properly combining the developed analytical reagents with an HPLC separation technique, one could determine ultra-small amounts of abused drugs such as stimulants, narcotics and obesity drugs in various matrices. Furthermore, chiral analyses of some abused drugs and evaluation of their potential for drug-drug interaction were also performed. The developed methods might be useful for forensic and toxicological studies on drug abuse. Also, the results obtained in our study might contribute to the prediction of and the protection of human health from risks of abused drugs.

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“…For safety precautions, sensitive monitoring of MO in blood or urine is necessary. Several methods have been developed for the detection and determination of MO, including sequential injection analysis method [13], cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography [14], fast Fourier transformation with continuous cyclic voltammetry method [15], gas chromatography -mass spectrometry [16], high-performance liquid chromatography -fluorescence method [17], liquid chromatography -electrospray ionization ion trap mass spectrometry [18], and microchip method [19]. However, these analytical methods are time-consuming and devices are expensive.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Oxidation and Detection of Morphine at Ordered Mesoporous Carbon Modified Glassy Carbon Electrodes

2009

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In this work, three ordered mesoporous carbons (OMCs) with different structural parameters were synthesized by a simple variation of the hydrothermal temperature of the silica templates (SBA-15). X-ray diffraction and nitrogen adsorption-desorption results show these OMCs exhibit an ordered 2D hexagonal mesostructure with tunable pore diameter. OMC-modified glassy carbon electrodes exhibit efficient electrocatalytic reactivity toward oxidation of morphine (MO). The amperometric detection of MO in pH 7.0 phosphate buffered saline at þ 0.39 V versus Ag/AgCl is the lowest potential reported to-date. A linear range from 0.2 to 197.6 mM and a detection limit of 0.03 mM MO were obtained.

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Sensitive HPLC–fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac

Abstract: microdialysates at a signal-to-noise ratio of 3 were 0.4 and 0.6 ng/ml, respectively. The proposed method was successfully applied to preliminarily study of potential pharmacokinetic interaction of Mor with diclofenac.

Cited by 16 publications

References 26 publications

Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain

Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain

Analytical Studies on the Development of High-Performance Liquid Chromatographic Methods with Fluorescence or Chemiluminescence Detections and Their Practical Applications

Electrochemical Oxidation and Detection of Morphine at Ordered Mesoporous Carbon Modified Glassy Carbon Electrodes

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