Sensitive electrochemical nonenzymatic glucose sensing based on anodized CuO nanowires on three-dimensional porous copper foam

Abstract

In this work, we proposed to utilize three-dimensional porous copper foam (CF) as conductive substrate and precursor of in-situ growth CuO nanowires (NWs) for fabricating electrochemical nonenzymatic glucose sensors. The CF supplied high surface area due to its unique three-dimensional porous foam structure, and thus resulted in high sensitivity for glucose detection. The CuO NWs/CF based nonenzymatic sensors presented reliable selectivity, good repeatability, reproducibility, and stability. In addition, the CuO NWs/CF based nonenzymatic sensors have been employed for practical applications, and the glucose concentration in human serum was measured to be 4.96 ± 0.06 mM, agreed well with the value measured from the commercial available glucose sensor in hospital, and the glucose concentration in saliva was also estimated to be 0.91 ± 0.04 mM, which indicated that the CuO NWs/CF owned the possibility for noninvasive glucose detection. The rational design of CuO NWs/CF provided an efficient strategy for fabricating of electrochemical nonenzymatic biosensors.

Ultrasensitive binder-free glucose sensors based on the pyrolysis of in situ grown Cu MOF

“…13 Furthermore, Zhang et al used Cu foam as the precursor for in-situ growth of CuO nanowires by anodic electrodeposition. 24 However, the preparation of electrodes based on binder-free carbon/Cu composite materials remains challenging.…”

Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring

“…The ability to monitor glucose accurately and regularly requires highly sensitive, highly selective, and reusable glucose sensors. [6][7][8][9][10]. A ZnO NR-based glucose sensor was tested by Wei et al Although ZnO NRs were grown on a thin gold film, the influence of gold was not investigated and the device was tested under 0.8 V. The obtained sensitivity was in the order of 23.1 µA·cm −2 ·mM −1 , and it was not filtered by subtracting the influences of the substrate [11].…”

Enzyme-free monitoring of glucose utilization in stimulated macrophages using carbon nanotube-decorated electrochemical sensor

“…This prompted the development of nano-structured interfaces that facilitated rapid electron transfer. However, enzymatic sensors are limited (Wang et al 2008a) by their instability due to changes in temperature and pH (Park et al 2006;Wang et al 2013;Li et al 2015). This has led to the development of the fourth generation of electrochemical sensors that are enzyme-free.…”