Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

Amoah, Abena S.; Hoekstra, Pytsje T.; Casacuberta-Partal, Miriam; Coffeng, Luc E.; Corstjens, Paul L. A. M.; Greco, Béatrice; Lieshout, Lisette van; Lim, Mark D.; Markwalter, Christine F.; Odiere, Maurice R.; Reinhard-Rupp, Jutta; Roestenberg, Meta; Stothard, J. Russell; Tchuenté, Louis-Albert Tchuem; Vlas, Sake J. de; Dam, Govert J. van

doi:10.1016/s1473-3099(20)30254-1

Cited by 35 publications

(37 citation statements)

References 65 publications

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“…Other Neglected Tropical Diseases (NTDs) apply Mass Drug Administration (MDA) for populations at high risk but for a relatively rare disease like leprosy, this is harder to justify. (Amoah et al, 2020) Yet as time goes by, these MDA programs for once highly prevalent diseases are beginning to face similar challenges as in leprosy. If clusters of high endemicity could be clearly outlined, strategies based on focal application of MDA could be considered.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Exploring clustering of leprosy in the Comoros and Madagascar: A geospatial analysis

Ortuño-Gutiérrez¹,

Mzembaba²,

Ramboarina³

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Exploring clustering of leprosy in the Comoros and Madagascar: A geospatial analysis

Ortuño-Gutiérrez¹,

Mzembaba²,

Ramboarina³

et al. 2021

International Journal of Infectious Diseases

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“…In addition, and though promising, assays such as LAMP and RPA to detect species-specific parasite DNA currently require further assessment and validation before their upscaled and routine use in such control programmes [ 81 , 85 ]. Nevertheless, continued development, assessment and validation of POC-RDTs is widely advocated as affordable and sensitive point-of-care diagnostics, capable of detecting low levels of infection within individuals able to maintain disease transmission, are sorely needed [ 86 ]. Given these challenges in reliably detecting infection using human samples, particularly in low-endemicity settings, alternative methods of detecting and monitoring disease transmission within endemic foci, such as parasite host surveillance and use of environmental DNA (eDNA), have also been explored.…”

Section: Intestinal Schistosomiasis and Giardiasis: Surveillance Amentioning

confidence: 99%

Intestinal Schistosomiasis and Giardiasis Co-Infection in Sub-Saharan Africa: Can a One Health Approach Improve Control of Each Waterborne Parasite Simultaneously?

et al. 2020

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Both intestinal schistosomiasis and giardiasis are co-endemic throughout many areas of sub-Saharan Africa, significantly impacting the health of millions of children in endemic areas. While giardiasis is not considered a neglected tropical disease (NTD), intestinal schistosomiasis is formally grouped under the NTD umbrella and receives significant advocacy and financial support for large-scale control. Although there are differences in the epidemiology between these two diseases, there are also key similarities that might be exploited within potential integrated control strategies permitting tandem interventions. In this review, we highlight these similarities and discuss opportunities for integrated control of giardiasis in low and middle-income countries where intestinal schistosomiasis is co-endemic. By applying new, advanced methods of disease surveillance, and by improving the provision of water, sanitation and hygiene (WASH) initiatives, (co)infection with intestinal schistosomiasis and/or giardiasis could not only be more effectively controlled but also better understood. In this light, we appraise the suitability of a One Health approach targeting both intestinal schistosomiasis and giardiasis, for if adopted more broadly, transmission of both diseases could be reduced to gain improvements in health and wellbeing.

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“…According to the World Health Organization (WHO), approximately 229 million people are infected worldwide, causing around 200,000 deaths annually (2). However, this is probably an underestimation, due to the low sensitivity of the available diagnostic methods to detect low intensity parasite infections (3,4). It ranks second behind malaria in terms of prevalence and socioeconomic impact, causing the loss of more than 2.6 million disability-adjusted life years (DALYs) (5).…”

Section: Introductionmentioning

confidence: 99%

Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence

et al. 2021

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Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma and affects over 200 million people worldwide. The control and treatment of this neglected tropical disease is based on a single drug, praziquantel, which raises concerns about the development of drug resistance. This, and the lack of efficacy of praziquantel against juvenile worms, highlights the urgency for new antischistosomal therapies. In this review we focus on innovative approaches to the identification of antischistosomal drug candidates, including the use of automated assays, fragment-based screening, computer-aided and artificial intelligence-based computational methods. We highlight the current developments that may contribute to optimizing research outputs and lead to more effective drugs for this highly prevalent disease, in a more cost-effective drug discovery endeavor.

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Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

Abstract: diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis. The Lancet Infectious Diseases. 2020.

Cited by 35 publications

References 65 publications

Exploring clustering of leprosy in the Comoros and Madagascar: A geospatial analysis

Exploring clustering of leprosy in the Comoros and Madagascar: A geospatial analysis

Intestinal Schistosomiasis and Giardiasis Co-Infection in Sub-Saharan Africa: Can a One Health Approach Improve Control of Each Waterborne Parasite Simultaneously?

Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence

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