Sensitive determination of enoxacin in pharmaceutical formulations by its quench effect on the fluorescence of glutathione‐capped CdTe quantum dots

Abstract

A sensitive and simple method for the determination of enoxacin (ENX) was developed based on the fluorescence quenching effect of ENX for glutathione (GSH)-capped CdTe quantum dots (QDs). Under optimum conditions, a good linear relationship was obtained from 4.333 × 10(-9) mol⋅L(-1) to 1.4 × 10(-5) mol⋅L(-1) with a correlation coefficient (R) of 0.9987, and the detection limit (3σ/K) was 1.313 × 10(-9) mol⋅L(-1). The corresponding mechanism has been proposed on the basis of electron transfer supported by ultraviolet-visible (UV) light absorption, fluorescence spectroscopy, and the measurement of fluorescence lifetime. The method has been applied to the determination of ENX in pharmaceutical formulations (enoxacin gluconate injections and commercial tablets) with satisfactory results. The proposed method manifested several advantages such as high sensitivity, short analysis time, low cost and ease of operation.

Fast quantification of fluoroquinolones in environmental water samples using molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry

“…Enoxacin (MW 320.12) belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives, widely used in the treatment of systemic infections. 36 The MS 2 spectrum for protonated enoxacin in the positive ion mode is shown in Fig. 2c , which shows [M–H 2 O + H] + at m / z 303 as the base peak accompanied by [M–CO 2 + H] + at m / z 277 and [M–CO 2 – HF + H] + at m / z 257.…”

“…Enoxacin (MW 320.12) belongs to the third generation of multiple uorinated antibacterial quinolone derivatives, widely used in the treatment of systemic infections. 36 The MS 2 spectrum for protonated enoxacin in the positive ion mode is shown in…”