Sensitive Determination of Acetaminophen in the Presence of Dopamine and Pyridoxine Facilitated by their Extent of Interaction with Single‐walled Carbon Nanotubes

Abstract

Single‐walled carbon nanotubes (SWCNTs) were immobilized on glassy carbon (GC) electrode by drop casting The resulting modified electrode (represented as GC/SWCNTs) efficiently oxidizes acetaminophen (AC), dopamine (DA) and pyridoxine (PY) by decreasing the respective oxidation potentials and increasing peak currents in comparison to bare GC electrode. The extent of lowering of overpotentials is in the order of AC>PY>DA, in agreement with the order of decrease in the HOMO‐LUMO energy gap (ΔE) of these analytes, as determined from Density Functional Theory (DFT) calculations. DFT calculations further reveal that due to the interaction of the analytes on the SWCNT(10,10) there is a negative charge density transfer (higher probability of electron transfer, lower ΔE value) to the frontier molecular orbitals of the analytes, which eases their oxidation. Since AC, DA and PY oxidize distinctly at distinct potential values, the present SWCNTs modified electrodes could be used to simultaneously determine them. Cyclic voltammetry, differential pulse voltammetry and amperometry techniques are utilized to understand the electrochemical characteristics of the analytes (AC, DA and PY) and subsequent sensing of them at the GC/SWCNTs electrode. The electrode is then applied to the determination of AC as a case study. Sensitivity, detection limit and linear calibration range for the AC are found to be 7.9 μA μM−1 cm−2, 1.1 μM and 2.0–100.0 μM, respectively. The increased electroactive surface area of the GC/SWCNTs increases the oxidation peak currents and hence increases the sensitivity of the determination.

Enhanced Electrochemical Sensing of Neurotransmitter in Serum and Injection Samples at Nickel (II) Hexacyanoferrate Deposited on Nanotubular Clay as Facile Electron Transfer Mediator

“…As can be seen, a bare GCE, and HNT/GCE shows a flat and drab voltammetric response in the presence of 0.1 M KCl containing PBS, while NiHCF@HNT/GCE exhibits better oxidative and reductive peak potentials were found to be +0.29 V and +0.23 V, and suitable peak potential separation (60 mV) that specifying this reaction is a single electron transfer process of hexacyanoferrate (III/II). 32 Reversibility and stability of the electrode have finalized by continuous potential cycles as shown in Fig. 3B, suggesting NiHCF@HNT/GCE is stable and reliable for electrochemical studies.…”

“…[28][29][30][31] The MHCF derived from various metal ions like Prussian blue, CuHCF, CoHCF, and NiHCF are widely used as electron transfer mediators for electrochemical sensing of biological molecules. [32][33][34][35][36][37] We have been working on developing electrode modification using nanotubular clay as solid support for the functionalization of various redox mediators. In the present work, we attempted to prepared nickel hexacyanoferrate redox mediator primed halloysite using PDDA as a cationic charged polymer electrolyte to deposit over the halloysite surface.…”

Barium Titanate Nanocubes as a Dual Electrochemical Sensor for Detection of Dopamine and Acetaminophen

“…So, it is very important to measure the concentration of Dopamine in the presence of Acetaminophen. In the literature, various electrodes such as gold nanoparticles, 18 modified gold electrodes, 19,20 carbon nanotubes and their composites, 21,22 TiO 2 nanoparticles 23 and many others have been reported for the detection of DA and APAP. [24][25][26][27] Some of the titanate-based compounds have been reported to exhibit strong chemical reactivity and good chemical stability in comparison to TiO 2 .…”

Síntese e aplicação de hexacianoferrato de zinco e seus nanocompósitos à base de nanoestruturas de carbono na degradação de contaminantes emergentes

“…168 Grupos funcionais presentes na superfície do grafeno e a presença de efeitos de borda (defeitos) podem facilitar as interações específicas adsorvente-adsorvato, sejam elas do tipo π-π "stacking", eletrostáticas, A grande eficiência do nanocompósito HCFZn/NTC no processo de degradação pode estar relacionada com uma diminuição do potencial de oxidação do paracetamol e consequente maior interação dos nanotubos de carbono com a molécula, aumentando a taxa de transferência eletrônica na superfície dos NTCs, facilitando assim a remoção do elétron do HOMO do paracetamol. 170 Os produtos de degradação do paracetamol após 10 minutos de exposição indicam uma redução significativa do composto.…”