Sensitive determination of 6-mercaptopurine based on the aggregation of phenylalanine-capped gold nanoparticles

Diamai, Siewdorlang; Warjri, Wandibahun; Saha, Dipika; Negi, Devendra P.S.

doi:10.1016/j.colsurfa.2017.11.052

Cited by 26 publications

(6 citation statements)

References 40 publications

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“…The absorption peak of the UVvis spectra blue-shifted, and the absorption intensity increased (Figure 1b), indicating the formation of smaller and more AuNPs, further confirmed by the corresponding TEM images (Figure S1). When 0.1 mg/mL bPEI was added, the molar ratio of HAuCl 4 to bPEI was 18 to 1, the absorption intensity reached the maximum value, and the absorption peak was located at 516 nm, a typical plasmon resonance absorption peak of AuNPs [34]. The above experimental results demonstrated that the bPEI could be used as both reductant and stabilizer to fabricate AuNPs with satisfactory stability and dispersion.…”

Section: Characterization Of Bpei@au and Bpei@au@-siomentioning

confidence: 67%

Multifunctional polyethyleneimine for synthesis of core-shell nanostructures and electrochemiluminescent detection of three AMI biomarkers

et al. 2021

Sci. China Chem.

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Simplicity and stability of an analytical method are the key to practical applications. In order to achieve such a goal, a molecule with multifunction could be one of the strategies. In this work, the multifunctional characteristics of branched polyethylenemine (bPEI) were employed for verification of this hypothesis. Three types of amines in the bPEI can be used to synthesize core-shell nanostructures (bPEI@Au and SiO 2 @bPEI@Au) in a simple one-pot process within 1 h, and as coreactants with over 500-fold enhancement for electrochemiluminescent (ECL) detection. Based on the remarkable performance of bPEI, a label-free ECL immunosensor and its array with the same assembly strategy were constructed for the simple and rapid determination of three acute myocardial infarction (AMI) biomarkers: cardiac troponin I (cTnI), human-type fatty acid binding protein (hFABP) and copeptin. Both methods exhibited excellent stability and sensitivity with wide linear range and low limits of detection down to fg/mL level by the photomultiplier tube and pg/mL level by the electron-multiplying charge-coupled device.

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Section: Characterization Of Bpei@au and Bpei@au@-siomentioning

confidence: 67%

Multifunctional polyethyleneimine for synthesis of core-shell nanostructures and electrochemiluminescent detection of three AMI biomarkers

et al. 2021

Sci. China Chem.

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“…e average values were used in developing linear regression model for each type of particles and found to be fitted with the following equations: Y � 138.6-9.875 X for Cit-HAuNPs and Y � 130.7-10.66 X for Cit-MAuNPs (Figure 12), where Y is the average RVs and X is the concentration of Ac. e slopes of the linear equations represent the sensitivity of both Cit-AuNPs to detect Ac [53][54][55][56]. e steeper slope of the Cit-MAuNPs regression compared with that of the Cit-HAuNPs indicates the detection based on Cit-MAuNPs is more sensitive.…”

Section: Image Processingmentioning

confidence: 99%

Image Digitization of Colorimetric Detection of Acephate Based on Its Complexation with Citrate-Capped Gold Nanoparticles

Osman

Yunus

Ong

et al. 2020

Journal of Chemistry

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Acephate (Ac), an organophosphate (OP) insecticide, is very harmful to human and the environment. Conventional techniques of detection are sensitive and selective but relatively time-consuming, expensive, and require trained personnel. This paper describes the use of an image processing technique to digitize the red values (RVs) of the colour image of Ac-capped gold nanoparticles (Ac-Cit-AuNPs) complex captured using a digital microscope to improve the detection accuracy and precision. The formation of the suspension was characterised using laser test, ultraviolet-visible spectrophotometer (UV-Vis), high-resolution transmission electron microscope (HRTEM), and Fourier Transform infrared spectroscope (FTIR). The linear regression analysis revealed that the detection sensitivity improved as the smaller gold nanoparticles were used. For quantitative measurement using image processing, a good linear relationship (R2 = 0.9905 and 0.9924) for Cit-HAuNPs and Cit-MAuNPs, respectively, between the concentration of Ac and average red values was obtained in the range of 0–8 mM. The limit of detection (LOD) for Ac was found to be 0.3 mM and 0.4 mM for Cit-MAuNPs and Cit-HAuNPs, respectively.

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“…In addition to this, phenylalanine is also found to be a good reducing agent as well as capping agent for AuNPs. 8,9 However, to synthesize stable NPs, additional reducing agent is required. 9 Since microwave chemistry has recently been reported to be effective in making size-and shape-controlled metallic NPs, we have used the same technology for the controlled synthesis of phenylalaninecoated AuNPs for sensing applications.…”

Section: Introductionmentioning

confidence: 99%

“…Coating with amino acids instead of peptides offers a further cost-effective approach (due to their ease of purification and availability), but it is presently an underutilized way to reduce toxicity and enhance stability. In addition to this, phenylalanine is also found to be a good reducing agent as well as capping agent for AuNPs. , However, to synthesize stable NPs, additional reducing agent is required . Since microwave chemistry has recently been reported to be effective in making size- and shape-controlled metallic NPs, we have used the same technology for the controlled synthesis of phenylalanine-coated AuNPs for sensing applications. − To further improve their applicability and specificity in analyte binding, phenylalanine-coated AuNPs were functionalized with a supramolecular host such as β-CD.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the β-Cyclodextrin-Driven Inclusion Complexation with Phenylalanine-Capped AuNPs for Colorimetric Detection of Cr(III) and Fe(III)

Trivedi,

Sharma,

Kaur

et al. 2024

ACS Appl. Nano Mater.

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Here, we highlight the synthesis of microwave-assisted monodisperse phenylalanine-capped AuNPs (F-AuNPs) in a one-step facile, cost-effective, eco-friendly process. The interaction of synthesized NPs was studied in the presence of macrocyclic supramolecule β-cyclodextrin (β-CD). Here, phenylalanine functions as both a reducing and capping agent, whereas β-CD forms an inclusion complex with phenylalanine, resulting in a ternary system, i.e., βCDF-AuNPs. The reaction parameters such as power, time, temperature, and concentrations of phenylalanine and HAuCl 4 for the synthesis of F-AuNPs were optimized and studied using UV− visible spectroscopy. The synthesized βCDF-AuNPs were found to be highly stable for more than a month The estimated average size of βCDF-AuNPs were found to be around 28 nm. These βCDF-AuNPs were employed to develop a highly selective and sensitive colorimetric sensor for Fe(III) and Cr(III) ions. With the addition of Fe(III) and Cr(III), the βCDF-AuNPs show a significant redshift, which resulted from the coordination between βCDF-AuNPs and metal ions [Fe(III) and Cr(III)]. The developed colorimetric sensor is ultrafast and has a limit of detection of 105 nM for Cr(III) and 152 nM for Fe(III). Moreover, selectivity experiments revealed that the colorimetric sensor is specific to Fe(III) and Cr(III) ions, even with the interference of other metal ions at very high concentrations.

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Sensitive determination of 6-mercaptopurine based on the aggregation of phenylalanine-capped gold nanoparticles

Cited by 26 publications

References 40 publications

Multifunctional polyethyleneimine for synthesis of core-shell nanostructures and electrochemiluminescent detection of three AMI biomarkers

Multifunctional polyethyleneimine for synthesis of core-shell nanostructures and electrochemiluminescent detection of three AMI biomarkers

Image Digitization of Colorimetric Detection of Acephate Based on Its Complexation with Citrate-Capped Gold Nanoparticles

Unraveling the β-Cyclodextrin-Driven Inclusion Complexation with Phenylalanine-Capped AuNPs for Colorimetric Detection of Cr(III) and Fe(III)

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