Sensitive detection of C-reactive protein using optical fiber Bragg gratings

Sridevi, S.; Vasu, K.I.; Asokan, S.; Sood, Anil K.

doi:10.1016/j.bios.2014.10.033

Cited by 82 publications

(47 citation statements)

References 28 publications

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“…As for biosensing applications, different types of nanocoatings are deposited on the fiber as improved substrates for the implementation of the selective biolayer, such as titania-silica sol-gel-derived nm-thick films [19], thin film of atactic polystyrenes (PS) [30], graphene oxide (GO) films [31], composites of GO film and single-walled carbon nanotubes (SWNTs) [32], or gold nanoparticles [33] with the purpose of improving the performance of the sensor by leading to greater sensitivities and lower detection limits. Figure 3A details the flow chart of the manufacturing steps for coating a μm-thick EFBG with GO and SWNTs, whereas Figure 3B accounts for a SEM image of the proposed sensor.…”

Section: How Can Nanotechnology Meet Ofg-based Sensing Platforms?mentioning

confidence: 99%

“…As shown in Table 1, in addition to IgG/anti-IgG immunoassays [19,30,[43][44][45], the use of antibodies as BRE was selected for proteic markers (C-reactive protein (CRP) [31], thyroglobulin [50], human transferrin [49]) and for receptors present on cell membranes [47,48] or bacteria [46].…”

Section: Applicationsmentioning

confidence: 99%

“…In particular, Sridevi and co-authors [31] realized an immunoassay for CRP coating the grating with a complex formed by the antibody (anti-CRP) and GO. This complex allowed reaching a quite low LOD (10 μg l −1 ) with a good specificity even in the presence of other interfering factors such as urea, creatinine, and glucose.…”

Section: Antibody-based Biosensingmentioning

confidence: 99%

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Biosensing with optical fiber gratings

et al. 2017

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Optical fiber gratings (OFGs), especially longperiod gratings (LPGs) and etched or tilted fiber Bragg gratings (FBGs), are playing an increasing role in the chemical and biochemical sensing based on the measurement of a surface refractive index (RI) change through a label-free configuration. In these devices, the electric field evanescent wave at the fiber/surrounding medium interface changes its optical properties (i.e. intensity and wavelength) as a result of the RI variation due to the interaction between a biological recognition layer deposited over the fiber and the analyte under investigation. The use of OFG-based technology platforms takes the advantages of optical fiber peculiarities, which are hardly offered by the other sensing systems, such as compactness, lightness, high compatibility with optoelectronic devices (both sources and detectors), and multiplexing and remote measurement capability as the signal is spectrally modulated. During the last decade, the growing request in practical applications pushed the technology behind the OFG-based sensors over its limits by means of the deposition of thin film overlays, nanocoatings, and nanostructures, in general. Here, we review efforts toward utilizing these nanomaterials as coatings for high-performance and low-detection limit devices. Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical applications. While high-performance metrics are starting to be achieved experimentally, there are still open questions pertaining to an effective and reliable detection of small molecules, possibly up to single molecule, sensing in vivo and multi-target detection using OFG-based technology platforms.

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Section: How Can Nanotechnology Meet Ofg-based Sensing Platforms?mentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

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Biosensing with optical fiber gratings

et al. 2017

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“…In fact, there are now so many methods of glucose testing, for instance, the photo acoustic spectroscopy, Raman spectroscopy, infrared spectroscopy [3][4][5], capacitive detection [6], surface plasmon resonance biosensor [7], colorimetry [8] and electrochemiluminescene [9]. Electrochemical glucose sensor has attracted tremendous attention because of its high selectivity, sensitivity and short response time [10].…”

Section: Introductionmentioning

confidence: 99%

Highly exposed copper oxide supported on three-dimensional porous reduced graphene oxide for non-enzymatic detection of glucose

Zhao

2015

Electrochimica Acta

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“…Inset: Shift in the Bragg wavelength as a function of concentration of only interfering factors such as urea (blue open squares), glucose (magenta open circles) and creatinine (red open stars). Reproduced with permission . Copyright 2015, Elsevier.…”

Section: Protein and Dna Sensingmentioning

confidence: 99%

The Roadmap of Graphene‐Based Optical Biochemical Sensors

Shivananju

Liu

et al. 2016

Adv Funct Materials

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Graphene is a novel two‐dimensional material composed of a one‐atom‐thick planar sheet of sp2‐bonded carbon atoms perfectly arranged in a honeycomb lattice that has exceptional photonic and electronic properties. We believe that the true potential of graphene lies in optical sensors, especially for biochemical sensing in the diagnostics and health care sector. Graphene has extraordinary properties, such as a one‐atom thickness, extremely high surface‐to‐volume ratio, large surface area, ability to quench fluorescence, excellent biocompatibility, broadband light absorption, ultrafast response time, high mechanical strength, outstanding robustness, and flexibility. The working principle is based on whenever the biomolecules come into contact with graphene, the Fermi level shifts to either p‐type or n‐type, changing the opto‐electronic properties. The most important factors in graphene‐based optical sensing are lowering the limit of detection and increasing the specificity of label‐free biochemical sensing. This article comprehensively and critically reviews emerging graphene optical biochemical sensors. We first elaborate on their opto‐electronic properties, fabrication, numerical modeling and simulation, and then review various sensing applications, such as single‐cell detection, neural imaging and optogenetics, colorimetric multifunctional sensors, cancer diagnosis, protein and DNA sensing, and gas sensing. Finally, the roadmap of current and future trends in graphene‐based optical biochemical sensors is discussed.

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Sensitive detection of C-reactive protein using optical fiber Bragg gratings

Cited by 82 publications

References 28 publications

Biosensing with optical fiber gratings

Biosensing with optical fiber gratings

Highly exposed copper oxide supported on three-dimensional porous reduced graphene oxide for non-enzymatic detection of glucose

The Roadmap of Graphene‐Based Optical Biochemical Sensors

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