Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core–shell nanoparticles

Zhang, Xuehong; Wei, Min; Lv, Bingjing; Liu, Yuanjian; Liu, Xu; Wei, Wei

doi:10.1039/c6ra04976a

Cited by 73 publications

(33 citation statements)

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“…In addition, we have found that Au@BDT@Ag@MPBA NPs are stable in 100 × 10 −6 m H 2 O 2 solution since their extinction spectrum barely changes after 1 h (Figure S6b, Supporting Information). We presume that the self‐assembled monolayer of 4‐MPBA protects the Ag shell from H 2 O 2 . Therefore, we can justifiably use these coefficients to represent the signals of each extracted pure spectra for further quantitative analysis.…”

Section: Resultsmentioning

confidence: 99%

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Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

et al. 2018

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Cholesterol is an essential molecule for many processes in the human body and many diseases such as hypertension, coronary heart disease, atherosclerosis, and lipid metabolism dysfunction can be detected in their early stages by monitoring intracellular cholesterol levels. Herein, metallic surface‐enhanced Raman scattering (SERS) core–shell nanoparticles with an embedded standard are designed for nondestructive detection of H2O2 and cholesterol. A classical least squares (CLS) spectral fitting method allows one to accurately extract the SERS signals of internal standards and target molecules from the multiplexed spectra. The embedded internal standard can be used to calibrate the SERS signals, removing fluctuations induced by differing measurement conditions and local states of the nanoparticles, such as aggregation. Thus, SERS signal reproducibility is improved and a better linear relationship in the working curve of detection is achieved. Using these SERS nanoprobes quantitative detection of H2O2 and cholesterol in solution and inside live cells at a single‐cell level is demonstrated.

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Section: Resultsmentioning

confidence: 99%

“…Therefore it is crucial to realize the detection of intracellular cholesterol. Various analytical methods have been developed for cholesterol detection in blood such as fluorescence, electrochemistry, and colorimetric methods . Nevertheless, there are very few reported strategies for intracellular cholesterol detection.…”

Section: Introductionmentioning

confidence: 99%

Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

et al. 2018

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“…Bimetallic nanomaterials consist of two metals and often display enhanced catalytic performance than their monometallic counterparts because of a synergistic effect. Therefore, the peroxidase‐like activity of bimetal nanomaterials such as Au@M (M = Ag, Pt, Bi, Cu), AgM (M = Au, Pd, Pt), and Fe–Co NPs are studied by some groups. The mechanism of peroxidase‐like activity of these metal nanomaterials is that metal nanomaterials can break up the OO bond of H 2 O 2 into two ·OH radical.…”

Section: Peroxidase‐like Activity Of Nanomaterialsmentioning

confidence: 99%

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Liu

Huang

Qin

et al. 2019

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Diabetes is a dominating health issue with 425 million people suffering from the disease worldwide and 4 million deaths each year. To avoid further complications, the diabetic patient blood glucose level should be strictly monitored despite there being no cure for diabetes. Colorimetric biosensing has attracted significant attention because of its low cost, simplicity, and practicality. Recently, some nanomaterials have been found that possess unexpected peroxidase‐like activity, and great advances have been made in fabricating colorimetric glucose biosensors based on the peroxidase‐like activity of these nanomaterials using glucose oxidase. Compared with natural horseradish peroxidase, the nanomaterials exhibit flexibility in structure design and composition, and have easy separation and storage, high stability, simple preparation, and tunable catalytic activity. To highlight the significant progress in the field of nanomaterial‐based peroxidase‐like activity, this work discusses the various smart nanomaterials that mimic horseradish peroxidase and its mechanism and development history, and the applications in colorimetric glucose biosensors. Different approaches for tunable peroxidase‐like activity of nanomaterials are summarized, such as size, morphology, and shape; surface modification and coating; and metal doping and alloy. Finally, the conclusion and challenges facing peroxidase‐like activity of nanomaterials and future directions are discussed.

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“…Although recent works have reported better limits of detection for glucose like some electrochemical or colorimetric methods, they usually require sophisticated devices or protocols, long procedure times, expensive reagents or the previous synthesis of the materials to use. Moreover, as it can be seen in Table S1, the majority of the colorimetric methods are based on the change of color from a chemical substrate or due to a morphological change of nanoparticles .…”

Section: Resultsmentioning

confidence: 98%

“…This system was selected considering glucose importance in clinical for diabetes management. During the last decades, glucose biosensor technology including point‐of‐care devices, continuous glucose monitoring systems and noninvasive glucose monitoring systems have been significantly improved and great efforts have been made to achieve better accuracy, precision and sensibility by using different techniques (colorimetry, photoelectrochemistry, electrochemistry). Here we present an easy colorimetric method that could be integrated in a smartphone application for a rapid, easy and cos‐effective determination of the desired analyte.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis and Characterization of Ag/Ag₂S Nanoparticles Enzymatically Grown In Situ and their Application to the Colorimetric Detection of Glucose Oxidase

et al. 2019

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This work describes a simple, fast and reproducible biochemical reaction to modulate the growth of silver/silver sulfide nanoparticles (Ag/Ag 2 S NPs) through the enzymatic activity of the glucose oxidase (GOx). This process occurs in aqueous buffered solutions at room temperature under physiological conditions with participation of inexpensive precursors. Oxidation of 1thio-β-D-glucose is catalyzed by GOx yielding hydrogen sulfide. Direct interaction between silver nitrate and enzymatically produced H 2 S in the presence of citric acid as capping agent leads to the generation of Ag/Ag 2 S NPs. UV-vis spectroscopy is employed to characterize absorbance spectra of resulting Ag/ Ag 2 S NPs with the highest signal-to-noise ratio at 385 nm. Enzymatically produced Ag/Ag 2 S NPs are characterized by TEM, XPS, DLS and XRD. This new colorimetric method was applied to the detection of enzymatic activity of GOx (LOD 0.557 μg mL-1 and linear range up to 1.5 μg mL-1). The effect of Dglucose on the read-out signal has been studied to confirm the enzymatic mechanism of this process (LOD 176.21 μM and linear range up to 1.25 mM) and was applied to the detection of glucose in human plasma.

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Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core–shell nanoparticles

Abstract: Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core–shell nanoparticles.

Cited by 73 publications

References 50 publications

Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Facile Synthesis and Characterization of Ag/Ag₂S Nanoparticles Enzymatically Grown In Situ and their Application to the Colorimetric Detection of Glucose Oxidase

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Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core–shell nanoparticles

Abstract: Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core–shell nanoparticles.

Cited by 73 publications

References 50 publications

Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Facile Synthesis and Characterization of Ag/Ag2S Nanoparticles Enzymatically Grown In Situ and their Application to the Colorimetric Detection of Glucose Oxidase

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Facile Synthesis and Characterization of Ag/Ag₂S Nanoparticles Enzymatically Grown In Situ and their Application to the Colorimetric Detection of Glucose Oxidase