Sensitisation and allergic reactions to alpha-1,3-galactose in Podlasie, Poland, an area endemic for tick-borne infections

Rutkowski, Krzysztof; Sowa, Paweł; Mroczko, Barbara; Pancewicz, Sławomir; Rutkowski, Ryszard; Czupryna, Piotr; Groblewska, Magdalena; Moniuszko‐Malinowska, Anna

doi:10.1080/23744235.2022.2057583

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…It seems that in Poland, tick-bite-related meat allergy is a rare clinical syndrome. Currently, only two studies on this subject are available [ 17 , 18 ]. However, it is not known whether this is really a rare syndrome of clinical symptoms or whether it is simply rarely recognized.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History

Lis

Ukleja-Sokołowska

Karwowska

et al. 2023

Life

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(1) Background: alpha-gal syndrome (AGS) is a serious, potentially life-threatening allergic reaction. This is a type of food allergy to red meat and other mammalian products (e.g., gelatin). In Poland, this problem seems to be rare or, more likely, very underdiagnosed. The diagnosis of AGS is difficult. It seems that the knowledge about this syndrome is insufficient. There are no effective diagnostic tools able to clearly diagnose this cross-reactive allergy. This paper presents the clinical application of a non-standard method in the diagnosis of a cross-reactive allergy using the example of AGS. (2) Methods: standard tests for in vitro allergy diagnostics and the non-standard ImmunoCAP inhibition test(IT) were carried out for serum collected from a patient with a red meat allergy. (3) Results: the serum concentration of anti-α-Gal IgE was very high (302 kUA/L), and IgE antibodies toanti-mammalian-meat allergens were found. The level of IgE antibodies to mammalian meat allergens decreased after blocking on α-GAL-CAP. The concentration of anti-α-Gal IgE decreased after blocking on CAPs coated with various mammalian meat allergens. Blocking with allergens of poultry meat did not affect the concentration of anti-α-Gal IgE. (4) Conclusions: the ImmunoCAP ITseems to be a useful tool in the diagnosis of cross-reactive allergies. Based on their clinical history and test results, the patient was diagnosed with AGS caused by a primary sensitization to α-Gal after a tick bite. This is the second case of AGS described in Poland and the first in Pomerania.

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Section: Discussionmentioning

confidence: 99%

“…To date, only one case of AGS has been described in Poland [ 17 ]. There is also one population analysis of the occurrence of anti-α-Gal IgE antibodies in forest workers from the Podlasie region [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History

Lis

Ukleja-Sokołowska

Karwowska

et al. 2023

Life

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“…Die Sensibilisierung erfolgt über Zeckenstiche, ohne dass es dabei notwendigerweise zu Infektionen mit durch Zecken ebenfalls übertragenen Pathogenen kommt [35].…”

Section: Sensibilisierungswegunclassified

Das Alpha-Gal-Syndrom – eine komplexe Allergie im interdisziplinären Kontext

Jappe¹

2023

Aktuelle Ernährungsmedizin

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Das Alpha-Gal-Syndrom umfasst eine um 3–12 Stunden verzögert einsetzende z.T. schwere Nahrungsmittelanaphylaxie. Diese Latenz kompliziert die Diagnosestellung ebenso wie die Tatsache, dass das auslösende Allergen ein Zucker ist, da proteinbasierte Testverfahren negativ bleiben können. Diese Arbeit beschreibt die Entdeckung dieser neuen Entität, ihre Ursachen, ihre Risiken und die relevante Diagnostik.

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“…They may cause local skin lesions and systemic reactions [e.g. [15][16][17][18] and induce meat allergies (alpha-gal syndrome) [19][20][21].…”

Section: Introduction and Objectivementioning

confidence: 99%

Copulation of <i>Ixodes ricinus</i> males and females on the host and its potential impact on pathogen transmission

Buczek,

Asman

et al. 2023

Ann Agric Environ Med.

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Introduction and Objective. The common tick Ixodes ricinus is one of Europe's most important vectors of tick-borne diseases. The increased risk of attacks by this tick suggests the need for identification of factors contributing to the transmission of tick-borne pathogens, and the routes of pathogen circulation in nature. Materials and method. Polymerase chain reaction was used to investigate the prevalence of four pathogens, i.e. Borrelia burgdorferi s.l. (Bb), Anaplasma phagocytophilum (Ap), Babesia spp. (Bs), and Bartonella spp. (Ba) in I. ricinus females and males mating on dogs in south-central Poland.Results. The study revealed the presence of three pathogens: Bb, Ap, and Bs in 9.4%, 5.4%, and 5.4% of all I. ricinus adults in copula, respectively. Co-infection with two pathogens was detected in one tick specimen. Borrelia burgdorferi spirochetes were isolated in two females and two males in copula, but the sexual transfer of the spirochetes between these specimens could not be clearly confirmed. Conclusions. By increasing the feeding dynamics in females, the copulation of I. ricinus males with females attached to the host's skin may stimulate pathogen replication in tick tissues and migration from the gut to the salivary glands. Further investigations of the I. ricinus copulation on the host on female feeding and pathogen transmission may contribute to the elucidation of the eco-epidemiology of tick-borne diseases transmitted by this tick species.

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Sensitisation and allergic reactions to alpha-1,3-galactose in Podlasie, Poland, an area endemic for tick-borne infections

Cited by 6 publications

References 33 publications

Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History

Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History

Das Alpha-Gal-Syndrom – eine komplexe Allergie im interdisziplinären Kontext

Copulation of <i>Ixodes ricinus</i> males and females on the host and its potential impact on pathogen transmission

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