Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Haouzi, Philippe; Chenuel, Bruno; Huszczuk, A

doi:10.1152/japplphysiol.00597.2003

Cited by 94 publications

(75 citation statements)

References 79 publications

(139 reference statements)

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“…It is also interesting to note that some group III and group IV afferents with free nerve endings in the triceps surae muscle increase their discharge in response to both the infusion of vasodilatory agents and in response to venous occlusion (17,18). Our previous reports (8,9) have shown that venous distension due to saline infusion into an arterially occluded forearm evokes a reflex increase in MSNA.…”

Section: Discussionmentioning

confidence: 90%

Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans

Cui

Blaha

Herr

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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-Venous saline infusions in an arterially occluded forearm evokes reflex increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP). We hypothesized that the application of suction to the human limbs would activate this venous distension reflex and raise sympathetic outflow. We placed airtight pressure tanks and applied 100 mmHg negative pressure to an arterially occluded limb (occlusion and suction, O&S) to induce tissue deformation without fluid translocation. BP, heart rate (HR), and MSNA were assessed in 19 healthy subjects during 2 min of arm or leg O&S. Occlusion without suction served as a control. During a separate visit, saline (5% forearm volume) was infused into veins of the arterially occluded arm (n ϭ 13). The O&S increased limb circumference, MSNA burst rate (arm: ⌬6.7 Ϯ 0.7; leg: ⌬6.8 Ϯ 0.7 bursts/min), and total activity (arm: ⌬199 Ϯ 14; leg: ⌬172 Ϯ 22 units/min) and BP (arm: ⌬4.3 Ϯ 0.3; leg: ⌬9.4 Ϯ 1.4 mmHg) from the baseline. The MSNA and BP responses during arm O&S correlated with those during leg O&S. Occlusion alone had no effect on MSNA and BP. MSNA (r ϭ 0.607) responses during arm O&S correlated with those evoked by the saline infusion into the arm. These correlations suggest that sympathetic activation during limb O&S is likely, at least partially, to be evoked via the venous distension reflex. These data suggest that suction of an occluded limb evokes sympathetic activation and that the limb venous distension reflex exists in arms and legs of normal humans.autonomic; blood pressure regulation; vessel PRIOR STUDIES HAVE SHOWN THAT the distension of abdominal veins increases sympathetic efferent activity in rabbits (2) and dogs (12). Limb venous ligation evokes vasoconstriction in both the occluded and contralateral extremities in dogs (5). Evidence in animals suggests that afferent nerve endings in peripheral veins may sense regional blood volume changes and, in turn, contribute to the blood pressure (BP) regulation via a reflex response in cats (11, 21), rabbits (2), and dogs (12). Venous distension increases the discharge of group III and IV afferent nerves in cat hindlimbs (18).Our recent reports (7-10) have shown that volume infusion (saline or albumin solution, 5% forearm volume, ϳ50 ml) into the veins of an occluded forearm evokes reflex increases in muscle sympathetic nerve activity (MSNA) and BP in human subjects. The magnitude of the MSNA and BP responses depends on the volume and the rate of the infusate during arm vein distension (8). When lidocaine is added to the forearm infusate, the MSNA and BP responses to venous distension are abolished (9). These observations clearly suggest that limb venous distension evokes a sympathoexcitatory reflex (termed venous distension reflex) and, thus, increases BP in humans. Of note, a recent report by Yamauchi et al. (33) has shown this reflex is also present in rats. Additionally, we have shown that venous infusion of albumin evokes a larger and more sustained increase in MSNA and BP than those with infusion of equal vo...

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Section: Discussionmentioning

confidence: 90%

Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans

Cui

Blaha

Herr

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

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“…In addition, the ventilation rate during muscle activity is suggested to be related to activity of group III and IV afferents by distension of blood vessels [20]. This observation can be linked with potential disruption of the microcirculation during eccentric exercise induced muscle damage [21], and this could have resulted in an elevation of minute ventilation [22]. Finally, impairment of group III and IV muscle afferents by lumbar intrathecal fentanyl injections reduced the ventilatory equivalent for CO2 during steady state cycling [23], thus damage-inducing downhill running exercise may occur with elevated discharge of group III and IV afferents, in turn elevating the ventilatory equivalents for O2 and CO2.…”

Section: Discussionmentioning

confidence: 99%

Effect of Level and Downhill Running on Breathing Efficiency

Cook

Myers

Kelly

et al. 2015

Sports

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Ventilatory equivalents for oxygen and carbon dioxide are physiological measures of breathing efficiency, and are known to be affected by the intensity and mode of exercise. We examined the effect of level running (gradient 0%) and muscle-damaging downhill running (−12%), matched for oxygen uptake, on the ventilatory equivalents for oxygen (V E/V Ο 2 ) and carbon dioxide (V E/V CO 2 ). Nine men (27 ± 9 years, 179 ± 7 cm, 75 ± 12 kg, V O 2max : 52.0 ± 7.7 mL· kg −1 · min −1 ) completed two 40-min running bouts (5 × 8-min with 2-min inter-bout rest), one level and one downhill. Running intensity was matched at 60% of maximal metabolic equivalent. Maximal isometric force of m.quadriceps femoris was measured before and after the running bouts. Data was analyzed with 2-way ANOVA or paired samples t-tests. Running speed (downhill: 13.5 ± 3.2, level: 9.6 ± 2.2 km· h −1 ) and isometric force deficits (downhill: 17.2 ± 7.6%, level: 2.0 ± 6.9%) were higher for downhill running. Running bouts for level and downhill gradients had V O 2 , heart rates and respiratory exchange ratio values that were not different indicating matched intensity and metabolic demands. During downhill running, the V E/V O 2 , (downhill: 29.7 ± 3.3, level: 27.2 ± 1.6) and V E/V CO 2 (downhill: 33.3 ± 2.7, level: 30.4 ± 1.9) were 7.1% and 8.3% higher (p < 0.05) than level running. In conclusion, breathing efficiency appears lower during downhill running (i.e., muscle-damaging exercise) compared to level running at a similar moderate intensity.

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“…The former hypothesis is that an augmentation in ventilation depends on the degree of an increase in cardiac output (right ventricular distension) 5) . The latter hypothesis resembles that of muscle mechanoreflex; the discharge of thin muscle afferents that respond to distension of blood vessels in exercising muscles contributes to ventilatory control 34) . (Fig.…”

Section: Origin Of the Phase I Ventilatory Responsementioning

confidence: 96%

“…We distinguish them from the conventional concept of central command 31) in this paper. Thirdly, some researchers have proposed a reflex mechanism from the cardiovascular system: cardiodynamic 5) and vascular distension hypotheses 34) . The former hypothesis is that an augmentation in ventilation depends on the degree of an increase in cardiac output (right ventricular distension) 5) .…”

Section: Origin Of the Phase I Ventilatory Responsementioning

confidence: 99%

Mechanism and implications of hyperpnea exaggeration at the onset of exercise in mechanical hyperalgesia after eccentric exercise

Hotta

Ishida

2018

JPFSM

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The ventilatory response to moderate-intensity step load exercise has three temporal phases: an initial rapidly increasing phase I, followed by a slower exponential phase II, that leads to the steady state phase III. In muscles with mechanical hyperalgesia (delayed onset muscle soreness) and/or muscle damage a few days after eccentric exercise (ECC), an interesting phenomenon of increased ventilatory response at phases II and III during constant-load exercise and incremental exercise has been reported. However, the mechanisms behind this phenomenon have not been clarified. At least a neural mechanism is partly responsible for this phenomenon because the ventilatory response at neurally modulated phase I has been shown to be exaggerated 2 days after ECC (D2). In the present review, we focus on our previous work to identify the potential mechanism underlying the exaggerated modulation in phase I ventilatory response at D2, in which ECC-induced muscle pain is assumed to be at the peak. We also discuss the physiological and practical implications of this phenomenon.

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Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Cited by 94 publications

References 79 publications

Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans

Limb suction evoked during arterial occlusion causes systemic sympathetic activity in humans

Effect of Level and Downhill Running on Breathing Efficiency

Mechanism and implications of hyperpnea exaggeration at the onset of exercise in mechanical hyperalgesia after eccentric exercise

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