Sensing ultra-trace dopamine by restoration of fluorescence on locally acidified gold nanoparticles

Hu, Feichi; Xu, Jiying; Chen, Yi

doi:10.1039/c9an00712a

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…In order to test our best sensor p-BAPCV ⊂ bCA in real conditions, we decided test the detection of 9 dopamine in human urine. Urine is known to contain traces of 9 dopamine due to metabolic activities in the human body [68,69] but it was not detected in the range of our sensor. In a first instance, we tested p-BAPCV in the presence of pure urine that was collected form two different persons.…”

Section: Test Of the Best Sensor In A Complex Samplementioning

confidence: 86%

Enzyvitands: versatile evolvable colorimetric chembioreceptors

Rossel

Bing

Gobat

2022

Preprint

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Designing the perfect sensor is the dream of any chemist. Since decades, a wide variety of synthetic receptors that targets analytes have been explored in chemistry. Their chemical optimisation is hard and does not guarantee success. In this context, we propose a fast and self-assembling colorimetric bio-chemical receptor coined Enzyvitand. It consists of only commercial chemicals and relies on the reunification of combinatorial chemistry, interactions of first and second coordination spheres interactions and indicators displacement assays that are harboured within a protein cavity. The sensor is highly modular, cheap and evolvable. Owing to it's solved X-ray structure and docking studies, we rationally designed it for the selective naked-eye recognition of dopamine over other neurotransmitters through the second coordination sphere. The supramolecular-anchored boronic acid into the protein allows also discrimination between (D)-Fructose versus dopamine relying on second coordination sphere. Hence, our sensor imitates a biological receptor for the recognition of neurotransmitters. Finally, it works in complex samples such as urine. Its immediate high versatility and evolvability are valuable for the selective detection of a wide assortment of analytes, ranging from small molecules up to micro-organisms. Regarding future applications, we anticipate new biotechnological or immunotherapeutic applications of our synthetic oligomer.

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Section: Test Of the Best Sensor In A Complex Samplementioning

confidence: 86%

Enzyvitands: versatile evolvable colorimetric chembioreceptors

Rossel

Bing

Gobat

2022

Preprint

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“…In recent years, DA detection has focused on fluorescence analysis because of its high sensitivity, wide linear range, low cost and use of simple equipment. 12,13…”

Section: Introductionmentioning

confidence: 99%

Carbon dots-decorated hydroxyapatite nanowires–lanthanide metal–organic framework composites as fluorescent sensors for the detection of dopamine

Sun

Zhang

et al. 2022

Analyst

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“…Gold nanocrystals (AuNCs) with specific morphologies have excellent physical and chemical properties and have been widely used in the fields of catalysis [1], chemical sensing [2], medical diagnosis [3], imaging analysis [4], and so on. The preparation of various AuNCs with precisely controlled morphologies and excellent functions by simple and effective methods is a hot spot in the interdisciplinary fields of nanoscience, materials science and analytical science nowadays.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of sea urchin-shaped Au nanocrystals by double-strand diblock oligonucleotides for surface-enhanced Raman scattering and catalytic application

et al. 2021

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It is of great significance to construct specially designed gold nanocrystals (AuNCs) with precisely controllable size and morphology to achieve an excellent physicochemical performance. In this work, sea urchin-shaped AuNCs with tunable plasmonic property were successfully synthesized by the hybridized double-strand poly adenine (dsPolyA) DNA-directed self-assembly technique. Hybridized dsPolyA as the directing template had suitable rigidity and upright conformation, which benefited the controllable formation of these anisotropic multi-branched AuNCs with the assistance of surfactant. The effects of essential conditions influencing the synthesis and precise morphology control were investigated in detail. COMSOL simulation was used to evaluate their electromagnetic field distribution according to their morphologies, and the result suggested that sea urchin-shaped AuNCs had abundant ‘hot spots’ for surface-enhanced Raman scattering (SERS) detection due to their regular nanoprotuberance structure. Finally, sea urchin-shaped AuNCs with excellent SERS and catalytic performance were applied for the quantitative analysis of food colorant and catalytic degradation of potential pollutants. The SERS enhancement factor of sea urchin-shaped AuNCs was up to 5.27 × 106, and the catalytic degradation rate for 4-NP by these AuNCs was up to −0.13min−1.

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Sensing ultra-trace dopamine by restoration of fluorescence on locally acidified gold nanoparticles

Abstract: An ultra-sensitive sensor was fabricated to measure dopamine through quenching and restoring FITC fluorescence by the competitive binding of dopamine and N-acetylneuraminic acid with mercaptophenylboronic acid anchored on the gold nanoparticles.

Cited by 7 publications

References 40 publications

Enzyvitands: versatile evolvable colorimetric chembioreceptors

Enzyvitands: versatile evolvable colorimetric chembioreceptors

Carbon dots-decorated hydroxyapatite nanowires–lanthanide metal–organic framework composites as fluorescent sensors for the detection of dopamine

Synthesis of sea urchin-shaped Au nanocrystals by double-strand diblock oligonucleotides for surface-enhanced Raman scattering and catalytic application

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