Sensing of uric acid via cascade catalysis of uricase and a biomimetic catalyst

Kim, Min Chul; Kwak, Jinyoung; Lee, Sang Yup

doi:10.1016/j.snb.2016.04.033

Cited by 26 publications

(17 citation statements)

References 23 publications

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“…In addition, other biomimetic cascade nanoreactors have been developed based on diverse cascade reaction systems, including alkaline phosphatase (ALP)-oxidase (OXD), [82,103] α-glucosidase (GAA)-GOx-POD, [21a] uricase (UOx)-POD, [79] UOx-CAT, [80] GSHOx-POD, [81] etc. [104] Using natural ALP and light responsive nanozymes, Jin et al developed an enzymatic cascade reaction system.…”

Section: Othersmentioning

confidence: 99%

“…[21a] UOx has also been integrated with nanozymes (e.g., POD-and OXD-like nanozymes) for the construction of biomimetic cascade nanoreactors. [79,80] For instance, Kim et al developed a novel biomimetic cascade catalytic system based on UOx and nanozymes (PMOx) for the detection of uric acid (UA). In the cascade catalytic system, UOx oxidized UA to produce H 2 O 2 , and the produced H 2 O 2 served as the substrate for the o-phenylenediamine (OPD) oxidation via POD-mimicking nanozymes.…”

Section: Othersmentioning

confidence: 99%

“…In the cascade catalytic system, UOx oxidized UA to produce H 2 O 2 , and the produced H 2 O 2 served as the substrate for the o-phenylenediamine (OPD) oxidation via POD-mimicking nanozymes. [79] Similarly, Jung et al developed a one-pot enzyme-nanozyme cascade using UOx and CAT-mimicking Au nanozyme for the treatment of hyperuricemia. [80] Using xanthine OXD and POD-mimicking 2D MOF nanozymes (i.e., NH 2 -Cu-MOF) with fluorescence properties, Hu et al developed a cascade nanoreactor as a hypoxanthine (Hx) assay (Figure 7A).…”

Section: Othersmentioning

confidence: 99%

See 2 more Smart Citations

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

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Multiple enzyme-driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits of these biological catalytic cascade systems, enormous efforts have been devoted to developing novel cascade catalytic systems to mimic biological cascade catalytic reactions over the past few years. Nanozymes, a class of enzyme mimics, are nanomaterials with enzyme-like catalytic activity. The emergence and development of nanozymes has significantly advanced the development of biomimetic cascade nanoreactors. Currently, biomimetic cascade nanoreactors driven by advanced nanozymes have been widely used and exhibit many advantages such as superior cascade catalytic efficiency and high stability, resulting in significant advancements in biosensing and biomedical applications. The latest advances in understanding the cascade catalytic mechanism of nanozyme-engineered biomimetic cascade catalytic nanoreactors and their progressive applications for biosensing and biomedical applications are comprehensively covered here. First, nanozyme and enzyme/nanozyme-engineered biomimetic cascade catalytic nanoreactors are categorized according to their catalytic mechanism and properties. Then, the biosensing and biomedical applications, including cancer therapy, antibacterial activity, antioxidation, and hyperuricemia therapy of the cascade catalytic systems are covered. The conclusion describes the most important challenges and opportunities remaining in this exciting area of research.

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Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

See 1 more Smart Citation

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

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“…In addition, H 2 O 2 can be the main intermediary reactant for immunoassays such as enzyme linked immunosorbent assay (ELISA) and chemiluminescence [ 22 , 23 ]. Furthermore, H 2 O 2 is a byproduct of general oxidation reactions from the catalytic process of glucose oxidase [ 24 ], amino-acid oxidase [ 25 ], uricase and so on [ 26 ]. Thus, accurate detection of H 2 O 2 or fabricating special sensing method based on the medium of H 2 O 2 is of practical importance in clinical and biological systems.…”

Section: Introductionmentioning

confidence: 99%

A Simple and Effective Colorimetric Assay for Glucose Based on MnO2 Nanosheets

Huang

Zheng

Feng

et al. 2018

Sensors

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Simple and effective methods for the detection of the level of blood glucose are closely linked to the monitoring of people’s health. In the study, MnO2 nanosheets with absorption range of 300 nm~500 nm and obvious yellow color were easily prepared and applied to detect glucose through their absorbance and color. The proposed method is based on the fact that a specific concentration of glucose can be quantitatively transformed into hydrogen peroxide (H2O2) under the catalytic effect of glucose oxidase. Based on the redox reaction of MnO2 with H2O2, yellow MnO2 can be converted into colorless Mn2+ to monitor the concentration of glucose. Under optimal conditions, a simple and effective visual assay for the sensitive and reliable detection of glucose was developed. The linear range was estimated to the range from 0 μM to 100 μM, with a detection limit of 12.8 μM. Furthermore, the proposed colorimetric assay based on MnO2 nanosheets can effectively detect blood glucose of clinical serum samples with accuracy and convenience.

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“…Although many spectrophotometric and thermometric methods have been developed for the measurement of uric acid level in serum and urine, these methods are inconvenient due to the requirement of an extra instrumentation and are thus not suitable for point-of-care applications or home-use test systems. Uricase was used conventionally to fabricate of amperometric biosensors, used to determine the concentration of uric acid in body fluids [3]. However, strong electrochemical interference from electroactive species, such as ascorbic acid (AA), in the biological samples exposes a severe problem for their practical operation in measurement of UA concentration with a working potential of above 0.4 V.…”

Section: Introductionmentioning

confidence: 99%

Sequential Measurement of Ascorbic Acid and Uric Acid Concentration by Linear Scan Voltammograms on The Plasma Treated Screen-Printed Carbon Paste Electrode

Chang¹,

Wang²,

Yuan³

et al. 2018

IJNTR

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Linear scan voltammograms of various concentrations of AA and UA was used to test the effect of screen-printed carbon electrode (SPCE) and oxygen plasma-treated SPCE's (OP-SPCE) ability to distinguish the oxidative peak potentials (E pa) of UA from AA. The oxygen plasma-treated SPCE (OP-SPCE) could make the oxidative peaks of ascorbic acid (AA) and uric acid (UA) on the linear scan voltammograms became more defined with the E pa to 150 mV (RSD =6.9%,n=7) and 350 mV (RSD =0.6%, n=7), respectively. While measuring a composite solution containing of AA and UA, the AA's current signals, generated at the shoulder of the AA peak curve on the linear scan voltammogram caused interference behavior thereby background currents presented to the uric acid's oxidative peak. The degree of background was found proportional to the concentration of AA in the composite solution with a linear regression equation of y = 0.0226x + 2.421 (R 2 =0.9962). A sequential measurement of ascorbic acid and uric acid concentration in a composition solution by linear scan voltammograms on the plasma treated screen-printed carbon paste electrode has developed: (1) determined the AA concentration (2) determined the degree of interference caused by AA at the uric acid's oxidative peak (3) the estimated interference-free UA peak current is determined by subtracting the level of AA interference. By using the fitting procedure, The UA concentration can be quantitatively and accurately analyzed. Excellent recovery rates (97.9 to 106%) and RSD of 1.4% were obtained for the measurement of UA, even in the presence of high concentrations of AA.

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Sensing of uric acid via cascade catalysis of uricase and a biomimetic catalyst

Cited by 26 publications

References 23 publications

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

A Simple and Effective Colorimetric Assay for Glucose Based on MnO2 Nanosheets

Sequential Measurement of Ascorbic Acid and Uric Acid Concentration by Linear Scan Voltammograms on The Plasma Treated Screen-Printed Carbon Paste Electrode

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