Sensing of doxorubicin hydrochloride using graphene quantum dot modified glassy carbon electrode

Materials Science and Engineering: C

Mokhtari

Shadjou

et al. 2017

Self Cite

This study reports on the electropolymerization of a low toxic and biocompatible polymer with entitle poly arginine-graphene quantum dots (PARG-GQDs) as a novel strategy for surface modification of glassy carbon (GC) surface and preparation a new interface for biomedical application. The fabrication of PARG-GQDs on GCE was performed using Layer-by-layer regime. Scanning electron microscopy (SEM) was confirmed dispersion of GQDs on the surface of PARG which lead to increase of surface coverage of PARG. The redox behavior of prepared sensor was then characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA), square wave voltammetry (SWV), linear sweep voltammetry (LSV). The electroactivity of PARG-GQDs coating towards detection and determination of malondialdehyde (MDA) as one of the most common biomarkers of oxidative stress, was then studied. Then, application of prepared sensor for the detection of MDA in exhaled breath condensate (EBC) is described. Electrochemical based sensor shows the lower limit of quantification (LLOQ) were 0.329nanomolar. This work is the first report on the integration of GQDs to poly amino acids. Further development can lead to monitoring of MDA or other exhaled breath biomarkers by GQDs functionalized poly amino acids in EBC using electrochemical methods.

Section: Electrodeposition Of Gqds On the Surface Of Parg Modified Gcementioning

confidence: 99%

Poly arginine-graphene quantum dots as a biocompatible and non-toxic nanocomposite: Layer-by-layer electrochemical preparation, characterization and non-invasive malondialdehyde sensory application in exhaled breath condensate

Materials Science and Engineering: C

Mokhtari

Shadjou

et al. 2017

Self Cite

“…In recent decades, graphene quantum dots (GQDs) films modified electrodes have been attracting great attentions due to their wide applications in the fields of electrochemical sensors . Because of remarkable advantages, such as low toxicity, easy preparation, high chemical stability, environmental friendliness, ability to transfer photo‐induced electron, and excellent photo‐stability, GQDs have been studied directly for electrochemical sensor applications …”

Section: Introductionmentioning

confidence: 99%

Electrochemical monitoring of aflatoxin M1 in milk samples using silver nanoparticles dispersed on α‐cyclodextrin‐GQDs nanocomposite

Shadjou

J of Molecular Recognition

Heidar-poor

et al. 2018

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Aflatoxins are potential food pollutants produced by fungi. One of important toxins is aflatoxin M1 (AFM1). A great deal of concern is associated with AFM1 toxicity. In the present study, an innovative electrochemical interface for quantitation of AFM1 based on ternary signal amplification strategy was fabricated. In this work, silver nanoparticles was electrodeposited onto green and biocompatible nanocomposite containing α-cyclodextrin as conductive matrix and graphene quantum dots as amplification element. Therefore, a multilayer film based on α-cyclodextrin, graphene quantum dots, and silver nanoparticles was exploited to develop a highly sensitive electrochemical sensor for detection of AFM1. Fully electrochemical methodology was used to prepare a transducer on a glassy carbon electrode, which provided a high surface area toward sensitive detection of AFM1. The surface morphology of electrode surface was characterized by high-resolution field emission scanning electron microscope. The proposed sensing platform provides a simple tool for AFM1 detection. Under optimized condition, the calibration curve for AFM1 concentration was linear in 0.015mM to 25mM with low limit of quantification of 2μM. The practical analytical utility of the modified electrode was illustrated by determination of AFM1 in unprocessed milk samples.

“…One of the best candidates for this purpose is graphene quantum dots (GQDs). Because of remarkable advantages, such as low toxicity, easy preparation, high chemical stability, environmental friendliness, ability to transfer photoinduced electron, and excellent photostability, GQDs have been studied directly for electrochemical sensor applications …”

Section: Introductionmentioning

confidence: 99%

“…Because of remarkable advantages, such as low toxicity, easy preparation, high chemical stability, environmental friendliness, ability to transfer photoinduced electron, and excellent photostability, GQDs have been studied directly for electrochemical sensor applications. [28][29][30][31][32][33] On the other hand, deposition of active GQDs into some polymer matrices has attracted great interest, 34 and the poly amino acids as biocompatible materials have been so widely studied. However, the polymer films based on poly amino are fragile; thus, different composite films based on beta-cyclodextrin and of chitosan (CS) and some tenacious materials have been suggested for GQDs immobilization on the surface of polymers.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical monitoring of malondialdehyde biomarker in biological samples via electropolymerized amino acid/chitosan nanocomposite

J of Molecular Recognition

Mokhtari

Jouyban-Gharamaleki

et al. 2018

Self Cite

This study reports on the electropolymerization of a low toxic and biocompatible nanopolymer with entitle poly arginine-graphene quantum dots-chitosan (PARG-GQDs-CS) as a novel strategy for surface modification of glassy carbon surface and preparation of a new interface for measurement of malondialdehyde (MDA) in exhaled breath condensate. Electrochemical deposition, as a well-controlled synthesis procedure, has been used for subsequently layer-by-layer preparation of GQDs-CS nanostructures on a PARG prepolymerized on the surface of glassy carbon electrode using cyclic voltammetry techniques in the regime of -1.5 to 2 V. The modified electrode appeared as an effective electroactivity for detection of MDA by using cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry. The prepared modified electrode demonstrated a noticeably good activity for electrooxidation of MDA than PARG. Enhancement of peak currents is ascribed to the fast heterogeneous electron transfer kinetics that arise from the synergistic coupling between the excellent properties of PARG and semiconducting polymer, GQDs as high density of edge plane sites and subtle electronic characteristics and unique properties of CS such as excellent film-forming ability, high permeability, good adhesion, nontoxicity, cheapness, and a susceptibility to chemical modification. The prepared sensor showed 1 oxidation processes for MDA at potentials about 1 V with a low limit of quantification 5.94 nM. Finally, application of new sensor for determination of MDA in exhaled breath condensate was suited. In general, the simultaneous attachment of GQDs and CS to structure of poly amino acids provides new opportunities within the personal healthcare.