Sensing of circulating cancer biomarkers with metal nanoparticles

Pallares, Roger M.; Thanh, Nguyễn Thị Kim; Su, Xiaodi

doi:10.1039/c9nr03040a

Cited by 75 publications

(45 citation statements)

References 348 publications

(351 reference statements)

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“…The nanomaterial-based LPS sensors have exploited versatile sensing principles, where the nanoparticle either being used as direct signal transducer, i.e., colorimetric sensing based on their aggregation (Figure 4(a)) or as signal amplifier in electrochemical sensors [62,68]. Metal nanoparticle aggregation-based colorimetric sensors are easy to use (mostly with simple mixing, followed by either visual inspection of color change or UV-vis measurement of the absorption spectrum) [70][71][72]. But they are prone to generate fault-positive results as they tend to aggregate in complex sample matrix.…”

Section: Biosensors For Cyanotoxins and Cyanobacteriamentioning

confidence: 99%

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

Sutarlie

Loh

2020

Research

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In aquaculture industry, fish, shellfish, and aquatic plants are cultivated in fresh, salt, or brackish waters. The increasing demand of aquatic products has stimulated the rapid growth of aquaculture industries. How to effectively monitor and control water quality is one of the key concerns for aquaculture industry to ensure high productivity and high quality. There are four major categories of water quality concerns that affect aquaculture cultivations, namely, (1) physical parameters, e.g., pH, temperature, dissolved oxygen, and salinity, (2) organic contaminants, (3) biochemical hazards, e.g., cyanotoxins, and (4) biological contaminants, i.e., pathogens. While the physical parameters are affected by climate changes, the latter three are considered as environmental factors. In this review, we provide a comprehensive summary of sensors, biosensors, and analytical technologies available for monitoring aquaculture water quality. They include low-cost commercial sensors and sensor network setups for physical parameters. They also include chromatography, mass spectrometry, biochemistry, and molecular methods (e.g., immunoassays and polymerase chain reaction assays), culture-based method, and biophysical technologies (e.g., biosensors and nanosensors) for environmental contamination factors. According to the different levels of sophistication of various analytical techniques and the information they can provide (either fine fingerprint, highly accurate quantification, semiquantification, qualitative detection, or fast screening), we will comment on how they may be used as complementary tools, as well as their potential and gaps toward current demand of real-time, online, and/or onsite detection.

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Section: Biosensors For Cyanotoxins and Cyanobacteriamentioning

confidence: 99%

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

Sutarlie

Loh

2020

Research

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“…Gold nanoparticles (AuNPs) are being widely investigated for applications in medical imaging, 1,2 bio-sensing, 3,4 drug delivery, 5,6 photothermal and photodynamic therapy, 7,8 owing to their small sizes, bio-compatibility, facile surface chemistry for bio-conjugation, and strong photothermal properties. Historically, AuNPs are well known to cell biologists for their widespread use as markers in electron microscopy (EM) 9 due to their high electron density and thus large contrast.…”

Section: Introductionmentioning

confidence: 99%

Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells

et al. 2020

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Gold nanoparticles have been researched for many biomedical applications in diagnostics, theranostics, and as drug delivery systems. When conjugated to fluorophores, their interaction with biological cells can be studied in situ and real time using fluorescence microscopy. However, an important question that has remained elusive to answer is whether the fluorophore is a faithful reporter of the nanoparticle location.Here, our recently developed four-wave-mixing optical microscopy is applied to image individual gold nanoparticles and in turn investigate their co-localisation with fluorophores inside cells. Nanoparticles from 10 nm to 40 nm diameter were conjugated to fluorescently-labeled transferrin, for internalisation via clathrin-mediated endocytosis, or to non-targeting fluorescently-labelled antibodies. Human (HeLa) and murine (3T3-L1) cells were imaged at different time points after incubation with these conjugates. Our technique identified that, in most cases, fluorescence originated from unbound fluorophores rather than from fluorophores attached to nanoparticles. Fluorescence detection was also severely limited by photobleaching, quenching and autofluorescence background. Notably, correlative extinction/fluorescence microscopy of individual particles on a glass surface indicated that commercial constructs contain large amounts of unbound fluorophores. These findings highlight the potential problems of data interpretation when reliance is solely placed on the detection of fluorescence within the cell, and are of significant importance in the context of correlative light electron microscopy. † Electronic supplementary information (ESI) available: Fig. S1-S17. See

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“…In targeted treatments of cancer, pharmaceuticals that can penetrate better in cancer cells are used for treatment and diagnosis. The distribution of nanoparticles is affected by various parameters which include their size and their ability to inactivate cancer cells [3,4]. In radiotherapy, ionizing radiations such as X-rays and gamma rays, high-energy particles are widely used for the treatment of cancer tumors in solid form.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Gold Nanoparticles Radio Sensitization Effect in Radiation Therapy of Cancer

Aghajanpour¹,

Aghaei²,

Haghighi³

et al. 2020

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In radiotherapy, ionizing radiations such as X-rays, gamma, high-energy particles are widely using for the treatment of cancer tumors in solid form. Unfortunately, ionizing radiations are not capable of detecting cancer cells from healthy cells. Therefore, healthy tissue hurts due to radiotherapy for eradicating the cancer cells. Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition curve which culminates in a localized, high radiation dose. Some studies indicated energy dependency of dose enhancement effect, and the others have studied the gold nanoparticle (GNP) size effect in association with photon energy. However, in some aspects of GNP-based radiotherapy the results of recent studies do not seem very conclusive in spite of relative agreement on the basic physical interaction of photoelectric between GNPs and low energy photons. The purpose of the current paper was to assess the current status of gold nanoparticles applications in radiation therapy. In this review, we summarized the mechanisms of action of radiation therapy with photons and ions in the presence and absence of nanoparticles, as well as the influence of some of the core and coating design parameters of nanoparticles on their radio sensitization capabilities.

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Sensing of circulating cancer biomarkers with metal nanoparticles

Abstract: In this comprehensive review, we summarize the current progress on metal nanoparticle-based analytical methods for the sensing of circulating cancer biomarkers, including cfDNA, ctDNA, miRNAs, CTCs and exosomes.

Cited by 75 publications

References 348 publications

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells

Evaluation of Gold Nanoparticles Radio Sensitization Effect in Radiation Therapy of Cancer

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