Sensing Applications via Energy Transfer from Conjugated Polyelectrolytes

Lv, Fengting; Wang, Shu; Bazan, Guillermo C.

doi:10.1002/9783527655700.ch6

Cited by 4 publications

(4 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those types of CPs that combine optoelectronic and redox properties of conventional conjugated polymers with aqueous solubility and ionic nature of polyelectrolytes are called “conjugated polyelectrolytes” (CPEs) categorized in cationic conjugated polyelectrolytes (CCPEs) and anionic conjugated polyelectrolytes (ACPEs)) . CPEs with poly(thiophene), poly(phenylene ethynylene), and poly(fluorene) backbones are the most common CPEs used for sensing purpose via fluorescence quenching, energy transfer, and based on a conformational changes mechanism. − In 1987, Wudl synthesized the first thiophene-based CPE by introducing the negative sulfonate groups into the terminal side chains of the polythiophene backbone . Afterward, the report on application of water-soluble anionic CP, for the amplification of the sensitivity to fluorescence quenching was the pioneering study that laid the foundation for designing the CPE-based biological and chemical sensors .…”

Section: A Review Of Conjugated Polymer-based Aptasensors Since 2010:...mentioning

confidence: 99%

Conjugated Polymers for Aptasensing Applications

Salimian

Nardin

2023

Biomacromolecules

View full text Add to dashboard Cite

Rapid and specific assaying of molecules that report on a pathophysiological condition, environmental pollution, or drug concentration is pivotal for establishing efficient and accurate diagnostic systems. One of the main components required for the construction of these systems is the recognition element (receptor) that can identify target analytes. Oligonucleotide switching structures, or aptamers, have been widely studied as selective receptors that can precisely identify targets in different analyzed matrices with minimal interference from other components in an antibody-like recognition process. These aptasensors, especially when integrated into sensing platforms, enable a multitude of sensors that can outperform antibody-based sensors in terms of flexibility of the sensing strategy and ease of deployment to areas with limited resources. Research into compounds that efficiently enhance signal transduction and provide a suitable platform for conjugating aptamers has gained huge momentum over the past decade. The multifaceted nature of conjugated polymers (CPs), notably their versatile electrical and optical properties, endows them with a broad range of potential applications in optical, electrical, and electrochemical signal transduction. Despite the substantial body of research demonstrating the enhanced performance of sensing devices using doped or nanostructure-embedded CPs, few reviews are available that specifically describe the use of conjugated polymers in aptasensing. The purpose of this review is to bridge this gap and provide a comprehensive description of a variety of CPs, from a historical viewpoint, underpinning their specific characteristics and demonstrating the advances in biosensors associated with the use of these conjugated polymers.

show abstract

Section: A Review Of Conjugated Polymer-based Aptasensors Since 2010:...mentioning

confidence: 99%

Conjugated Polymers for Aptasensing Applications

Salimian

Nardin

2023

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…Conjugated polymers (CP) are an important class of organic semiconductor materials with unique properties, such as structural and functional versatility, solution processability, low density, and low processing cost . The introduction of ionic or hydrophilic pendant groups confers to the CP water solubility which makes them appealing candidates as optical sensors for a wide range of chemical and biological systems, conjugated polyelectrolytes (CPEs) providing a prime example. − …”

Section: Introductionmentioning

confidence: 99%

Nanostructuring with Surfactants: The Self-Assembly of a New Poly(thiophene-phenylene) Conjugated Polymer Bearing Azacrown Ether Pendant Groups

et al. 2022

View full text Add to dashboard Cite

We report the synthesis of a new conjugated polymer bearing crown ether moieties, poly [(N(1-aza-[18]crown-6)carbamido)thiophene-2,5-diyl-alt-1,4-phenylene] (BG2). In water, BG2 forms a dispersion with a slightly cloudy appearance. We have studied the effect of adding surfactants, with different polar head groups, on these polymer−polymer aggregates. Special attention is given to the system with the anionic surfactant, sodium dodecyl sulfate (SDS). The combination of photophysical techniques with electrical conductivity, NMR ( 1 H, 13 C, and 27 Na), DFT calculations, molecular dynamics simulations, and small-angle neutron scattering (SANS) provides a detailed picture on the behavior of the SDS/BG2 system in aqueous solution and in thin films. NMR, electric conductivity, and DFT results suggest that hydrophilic interactions occur between the polar headgroup of the surfactant (OSO 3 − Na + ) and the aza-[18]-crown-6 moiety. DFT calculations confirmed the capability of BG2 to form stable complexes with the Na + cations, where the cation can be either inside the azacrown cavity or sandwiched between the cavity and the polymer chain, which seem to determine the position of the surfactant hydrocarbon chain and, therefore, be responsible for the disruption of the BG2 aggregates and subsequent increase in the photoluminescence quantum yields. SANS measurements, made with hydrogenated and deuterated SDS in D 2 O, clearly show how micron-sized aggregates of BG2 are broken down by SDS and then how BG2 becomes preferentially incorporated within joint colloidal particles of BG2 and SDS with increasing [SDS]/[BG2] molar ratio.

show abstract

“…15 The exciton diffusion process and correlated optical response are closely related to the electronic and structural conformation of the polymer backbone, which can be synthetically tuned to incorporate molecular design features that enhance intra-and intermolecular exciton delocalization, leading to stronger amplified signals and detectivity at nanomolar concentrations. 16 This hallmark signal amplification, coupled with the ability to tailor the optical response to various analytes with a diverse set of compatible receptor chemistries, has enabled the development of selective and sensitive CP-based sensors. 18 CPE-based chemosensors have been reported for the selective detection of PPi in aqueous media, such as an on−off−on fluorescent assay based on a sulfonate functionalized poly-(fluorene-co-phenylene) copolymer.…”

mentioning

confidence: 99%

“…Binding events along the polymer capture the diffusing exciton resulting in the collective response of each repeat unit within the exciton diffusion length . The exciton diffusion process and correlated optical response are closely related to the electronic and structural conformation of the polymer backbone, which can be synthetically tuned to incorporate molecular design features that enhance intra- and intermolecular exciton delocalization, leading to stronger amplified signals and detectivity at nanomolar concentrations. , …”

mentioning

confidence: 99%

Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater

Williams

Tropp

Crater

et al. 2019

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

The evolution of conjugated polyelectrolytes (CPEs) that transduce analyte−receptor interactions into detectable fluorescent responses in complex aqueous environments is predicated on advancements in molecular design and improved synthetic accessibility. Here, we demonstrate a simple postpolymerization modification protocol, based on thiol−ene click chemistry, that results in the rapid installation of sodium sulfate terminated side-chains to a poly(fluorene-co-ethynyl) scaffold. The fluorescence of the resulting water-soluble CPE is quenched by Fe 3+ , dequenched selectively by pyrophosphate (PPi), and accurately quantifies PPi within ±6 nM in artificial seawater. The broad utility of thiol−ene click chemistry should offer the straightforward integration of diverse sensing elements.

show abstract

Sensing Applications via Energy Transfer from Conjugated Polyelectrolytes

Cited by 4 publications

References 89 publications

Conjugated Polymers for Aptasensing Applications

Conjugated Polymers for Aptasensing Applications

Nanostructuring with Surfactants: The Self-Assembly of a New Poly(thiophene-phenylene) Conjugated Polymer Bearing Azacrown Ether Pendant Groups

Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater

Contact Info

Product

Resources

About