Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study

Mantia, Ignazio La; Ragusa, M A; Grigaliute, Egle; Cocuzza, S; Radulesco, Thomas; Calvo‐Henríquez, Christian; Saibene, Alberto Maria; Riela, Paolo Marco; Lechien, Jérôme R.; Fakhry, Nicolas; Michel, J.

doi:10.1007/s00405-023-07855-8

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…In addition, more feasible and easy questionnaire that associated with symptoms may be used to reduce time consuming in the future. 41 …”

Section: Discussionmentioning

confidence: 99%

Down Regulation of EGF and AZGP1 Were Associated with Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps: An Observation Study

Jin,

Zhang,

Zang

et al. 2023

JIR

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Objective The mechanisms underlying the chronic rhinosinusitis with nasal polyps (CRSwNP) remained unclear. This study aimed to identify differentially expressed genes (DEGs) in nasal polyps from CRSwNP patients compared to healthy controls and explore key genes and pathways associated with CRSwNP pathophysiology and prognosis. Methods Three datasets were obtained from the Gene Expression Omnibus database and the intersecting DEGs were identified in CRSwNP patients. Gene Ontology (GO) and protein-protein interaction (PPI) network analysis were applied to investigate the function of DEGs. Nasal specimens from 90 CRSwNP and 45 controls were further collected and qRT-PCR was applied to verify the mRNA expression of hub genes, and moreover, their association with tissue eosinophilia and clinical characteristics in CRSwNP were analyzed. Results Sixty-eight co-DEGs including 8 upregulated and 60 downregulated genes were identified and GO analyses identified the terms including positive regulation of ERK1 and ERK2 cascade, transforming growth factor beta receptor signaling pathway. PPI networks identified hub genes including EGF, ERBB4, AZGP1, CRISP3 and PIP which were validated to be significantly down-regulated in CRSwNP and showed well diagnostic prediction quality. In addition, lower mRNA expressions level of EGF and AZGP1 in eosinophilic CRSwNP compared with non-eosinophilic CRSwNP were found. Aberrant low expressions of EGF and AZGP1 protein in CRSwNP were identified, and there was good consistency between their mRNA expression level and protein relative expression level. Furthermore, the expressions of EGF and AZGP1 mRNA were significantly correlated with clinical severity parameters. Conclusion Integrated analysis revealed 68 co-DEGs between nasal polyps and controls and identified hub genes, of which EGF and AZGP1 expression was significantly downregulated in eosinophilic CRSwNP and correlated with disease severity. Downregulation of EGF and AZGP1 may contribute to epithelial barrier dysfunction and type 2 inflammation in CRSwNP, suggesting them as potential diagnostic biomarkers and therapeutic targets.

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“…In addition, more feasible and easy questionnaire that associated with symptoms may be used to reduce time consuming in the future. 41 …”

Section: Discussionmentioning

confidence: 99%

Down Regulation of EGF and AZGP1 Were Associated with Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps: An Observation Study

Jin,

Zhang,

Zang

et al. 2023

JIR

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“…However, at the six-month FU, the pooled result of two studies ( n = 147) showed a significantly greater improvement in total SNOT-20 scores in the groups that received CHMs, with no heterogeneity. Future studies could consider using SNOT-8 as a more feasible and accessible subjective score for symptoms assessment [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…Were Sino-Nasal Outcome Test (SNOT), including SNOT20 [ 57 ], SNOT22 [ 58 ] and SNOT8 [ 59 ], visual analogue scale for total nasal symptoms (VAS-TNS) and/or VAS for individual symptoms (VAS-IS), Lund-Mackay computed tomography score (LM) [ 60 ], Lund-Kennedy endoscopic score (LK) [ 61 , 62 ], Mucociliary transport time (MTT) [ 63 ], Mucociliary transport rate (MTR), Mucociliary clearance as percentage (MC), and adverse events (AEs) [ 64 ]. Effective rate scales not used internationally, and measures developed by the authors were excluded.…”

Section: Methodsmentioning

confidence: 99%

Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis

Cui,

Lin,

May

et al. 2023

PLoS ONE

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This systematic review and meta-analysis aims to: assess the effectiveness and safety of orally administered Chinese herbal medicines (CHMs) as adjuncts to the post-surgical management of chronic rhinosinusitis (CRS); inform clinicians of the current evidence; identify the best available evidence; and suggest directions for further research. Randomised controlled trials (RCTs) were identified from searches of nine databases plus clinical trial registries. Participants were adults and/or children diagnosed with sinusitis or rhinosinusitis, with or without nasal polyps, who had received surgery. Interventions were CHMs used orally following surgery for CRS as additions to conventional post-surgical management. Controls received conventional post-surgical management without CHMs. Studies reported results for Sino-Nasal Outcome Test (SNOT), visual analogue scales (VAS), Lund-Mackay computed tomography score (LM), Lund-Kennedy endoscopic score (LK), mucociliary transport time (MTT), mucociliary transport rate (MTR), mucociliary clearance (MC) or quality of life (QoL). Twenty-one RCTs were included. All used oral CHMs following functional endoscopic sinus surgery (FESS). The pooled results showed no significant difference between groups for SNOT-20 at the end of treatment (EoT) but there was a significant difference at follow up (FU) in favour of additional CHMs. The VAS for total nasal symptoms (VAS-TNS) showed greater improvements in the CHM groups at EoT and FU. Only FU data were reported for LM which showed greater improvement in the CHM groups. LK showed greater improvements at EoT and FU. The measures of mucociliary transport (MTT, MTR, and MC) each showed significantly greater improvement at EoT in the group that received additional CHMs. No study reported QoL. Adverse events were not serious, but reporting was incomplete. The meta-analyses suggested the addition of oral CHMs to conventional management following FESS may improve recovery. However, most studies were not blinded, and substantial heterogeneity was evident in some meta-analyses. Blinded studies are required to further investigate the roles of oral CHMs in post-surgical recovery. Systematic review registration number: The protocol was registered in PROSPERO (CRD42019119586).

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“…Langdon et al ( 48 ) administered the SNOT-22 as an additional/complementary outcome measure to investigate QoL in PTOD patients. In fact, the tool seems particularly useful in detecting changes in QoL according to smell symptoms ( 53 , 54 ). In this vein, Neumann et al ( 19 ) investigated the PTOD in moderate and severe TBI by assessing also emotional sequelae, through the administration of a complete battery, which included: (i) Olfaction (Brief Smell Identification Test-BSIT) ( 41 ); (ii) facial affect recognition [Diagnostic Assessment of Nonverbal Affect 2-Adult Faces (DANVA2-AF)] ( 55 ); (iii) vocal affect recognition [Diagnostic Assessment of Nonverbal Affect 2-Adult Paralanguage (DANVA2-AP)] ( 56 ); (iv) emotional inference [Emotional Inference from Stories Test (EIST)] ( 57 ) and (v) empathy [Interpersonal Reactivity Index (IRI)] ( 58 ).…”

Section: Subjective and Objective Assessment Methods In Olfactionmentioning

confidence: 99%

Post-traumatic olfactory dysfunction: a scoping review of assessment and rehabilitation approaches

et al. 2023

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Post-traumatic Olfactory Dysfunction (PTOD) consists of a complete or partial loss of olfactory function that may occur after a traumatic brain injury (TBI). PTOD may be linked to some neuropsychiatric features, such as social, cognitive and executive dysfunction, as well as behavioral symptoms, especially when TBI involves the orbito-frontal cortex. The diagnosis of PTOD is based on medical history and clinical data and it is supported by psychometric tests (i.e., subjective tools) as well as electrophysiological and neuroimaging measures (i.e., objective methods). The assessment methods allow monitoring the changes in olfactory function over time and help to establish the right therapeutic and rehabilitative approach. In this context, the use of the olfactory training (OT), which is a non-pharmacological and non-invasive treatment option, could promote olfactory function through top-down (central) and bottom-up (peripheral) processes. To better manage patients with TBI, PTOD should be detected early and properly treated using the various therapeutic rehabilitative possibilities, both conventional and advanced, also taking into consideration the emerging neuromodulation approach.

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Sensibility, specificity, and accuracy of the Sinonasal Outcome Test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study

Cited by 11 publications

References 26 publications

Down Regulation of EGF and AZGP1 Were Associated with Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps: An Observation Study

Down Regulation of EGF and AZGP1 Were Associated with Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps: An Observation Study

Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis

Post-traumatic olfactory dysfunction: a scoping review of assessment and rehabilitation approaches

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