Sensibilidad química múltiple: evaluación clínica de la gravedad y perfil psicopatológico

Blanco, Eva Lago; Ferrando, Josep; Enríquez, Mónica Rodríguez; Gento, Laura Agüero; Coll, Joan Salvà; Portell, Maria Rosa Pizà

doi:10.1016/j.medcli.2015.09.016

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…This likely was not due to recruitment bias, which was random. The preponderance of women with CI is consistent with global population-based studies [ 32 – 35 ]. In a Japanese population-based study, CI among females was approximately twofold higher than in males [ 7 ].…”

Section: Discussionsupporting

confidence: 87%

Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI)

et al. 2020

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The Quick Environmental Exposure and Sensitivity Inventory (QEESI) is a validated questionnaire used worldwide to assess intolerances to chemicals, foods, and drugs, and has emerged as the gold standard for assessing chemical intolerance (CI). Despite a reported prevalence of 8-33%, epidemiological studies and routine primary care clinics rarely assess CI. To help address this gap, we developed the Brief Environmental Exposure and Sensitivity Inventory (BREESI)-a 3-item CI screening tool. We tested the BREESI's potential to predict whether an individual is likely to be classified as chemically intolerant if administered the 50-item QEESI. We recruited 293 participants from a university-based primary care clinic and through online participation. The statistical sensitivity, specificity, and positive and negative predictive values of the BREESI were calculated against the validated QEESI. Ninety percent (90%) of participants answering "yes" to all three items on the BREESI fit the QEESI criteria for being very suggestive of CI based upon their chemical intolerance and symptom scores (positive predictive value = 90%). For participants endorsing two items, 93% were classified as either very suggestive (39%) or suggestive (54%) of CI (positive predictive value = 87%). Of those endorsing only one item, 13% were classified as very suggestive of CI, and 70% as suggestive. Of those answering "No" to all of the BREESI items, 95% were classified as not suggestive of CI (i.e., negative predictive value = 95%). The BREESI is a versatile screening tool for assessing potential CI useful for clinical and epidemiological applications, based upon individuals' past adverse responses in a variety of settings. Just as health care professionals routinely inquire about latex allergy to prevent adverse reactions, the BREESI provides an essential screen for CI. Together, the BREESI and QEESI provide new diagnostic tools that may help predict and prevent future adverse reactions to chemicals, foods, and drugs.

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Section: Discussionsupporting

confidence: 87%

Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI)

et al. 2020

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“…Multiple chemical sensitivity (MCS) syndrome is a medically unexplained condition characterized by the appearance of symptoms in various organs and systems when the subject is exposed to odours of chemicals that are usually present in the environment at concentrations that are not related to hypersensitivity in the general population [ 1 , 2 , 3 , 4 ]. MCS patients related such reactions to exposure to such different chemicals as solvents, hydrocarbons, organophosphates, and heavy metals.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the World Health Organization has not recognized MCS as an organic, chemical-caused illness [ 3 ]. This condition has not been associated with objective pathophysiological processes [ 10 ], and many hypotheses have been formulated to explain its etiopathogenesis, including increase of histamine, involvement of immunological or inflammatory factors, psychological aspects, neurogenic inflammation, chronic hypoxia, and classical conditioning [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms

Casale

Ferracuti

Mosca

et al. 2020

IJERPH

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Multiple Chemical Sensitivity (MCS) is a chronic and/or recurrent condition with somatic, cognitive, and affective symptoms following a contact with chemical agents whose concentrations do not correlate with toxicity in the general population. Its prevalence is not well defined; it mainly affects women between 40 and 50 years, without variations in ethnicity, education and economic status. We aimed to assess the core symptoms of this illness in a sample of Italian patients. Two physicians investigated different symptoms with a checklist compilation in 129 patients with MCS (117 women). We conducted a categorical Principal Component Analysis (CATPCA) with Varimax rotation on the checklist dataset. A typical triad was documented: hyperosmia, asthenia, and dyspnoea were the most common symptoms. Patients also frequently showed cough and headache. The CATPCA showed seven main factors: 1, neurocognitive symptoms; 2, physical (objective) symptoms; 3, gastrointestinal symptoms; 4, dermatological symptoms; 5, anxiety-depressive symptoms; 6, respiratory symptoms; 7, hyperosmia and asthenia. Patients showed higher mean prevalence of factors 7 (89.9%), 6 (71.7%), and 1 (62.13%). In conclusion, MCS patients frequently manifest hyperosmia, asthenia, and dyspnoea, which are often concomitant with other respiratory and neurocognitive symptoms. Considering the clinical association that is often made with anxiety, more studies are necessary on the psychosomatic aspects of this syndrome. Further analytical epidemiological studies are needed to support the formulation of aetiological hypotheses of MCS.

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“…Current evidence suggests that certain individuals are more prone to developing intolerances to one or multiple chemicals causing multi-symptom organ and system manifestations or multiple chemical sensitivity (MCS) or toxicant-induced loss of tolerance (TILT) (1–6). Multiple chemical sensitivity is a clinical condition consisting of adverse health effects to low-dose exposures to common substances such as fragrances, household cleaners, organophosphate pesticides, fuels and metals (7, 8). MCS patients with pre-exposures to chemicals report similar patterns of multisystem symptoms and new-onset intolerances when exposed to chemicals again.…”

Section: Introductionmentioning

confidence: 99%

Repeated pulmonary exposures to zinc ions enhance inflammatory responses to subsequent metal exposures

Watson-Wright¹,

Queiroz²,

Rodrigues³

et al. 2018

Experimental Lung Research

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Aim of study: Metal contaminants contribute to adverse human health effects via acute and chronic exposures. Acute metal exposures followed by prolonged secondary metal exposures may elicit exaggerated inflammatory responses in certain individuals. The aim of this study is to determine whether repeated pulmonary exposures to zinc chloride (ZnCl2) alters subsequent responses to zinc or cerium exposures. Materials and Methods: Rats were intratracheally (IT) instilled with physiologic saline (n=24) or 0.05 mg/kg ZnCl2 (n=16) twice weekly for 4 weeks. Four days after last dosing, the saline group was divided into 3 subgroups, each IT-instilled with either saline, ZnCl2 or CeCl3 (both at 0.1 mg/kg). The ZnCl2 pre-instilled rats were divided into 2 subgroups, each instilled with 0.1 mg/kg ZnCl2 or CeCl3. Biomarkers of lung injury/inflammation were assessed in bronchoalveolar lavage (BAL) fluid collected 24 hours later. Oxidative stress was evaluated as total and reduced glutathione in BAL. Results: Increases in inflammatory cells, LDH, albumin, leptin, MCP-1, IP-10, fractalkine, TNFα and RANTES were observed in rats instilled with multiple PBS and then with 0.1 mg/kg ZnCl2 and CeCl3. However, rats pre-exposed repeatedly to 0.05 mg/kg ZnCl2 and then challenged with 0.1 mg/kg ZnCl2 or CeCl3 showed even more eosinophils, lymphocytes, and increased concentrations of hemoglobin and MIP-1α. Significant reduction in GSH/GSSG ratios in BAL in response to all ZnCl2 or CeCl3 exposures indicated oxidative stress. Conclusion: Previous exposure to zinc ions increases responsiveness to subsequent exposures to zinc and cerium ions. These findings suggest enhanced sensitization possibly due to a reduction in antioxidant defenses.

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Sensibilidad química múltiple: evaluación clínica de la gravedad y perfil psicopatológico

Cited by 11 publications

References 15 publications

Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI)

Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI)

Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms

Repeated pulmonary exposures to zinc ions enhance inflammatory responses to subsequent metal exposures

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