Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study

Abstract

HighlightsSOC was compared to clinical biomarkers in 125 people with type 1 diabetes.No association between SOC and HbA1c was found.An independent association between high SOC and lower LDL-C was found.

Relación entre sentido de coherencia y diabetes mellitus: una revisión sistemática

“…Only one study referred to a positive and significant correlation between SOC and A1c 44 . Other studies reported no association between SOC and biomarkers such as: A1c 23,26,27 , triglyceride levels 23 , BMI 21,24 , HDL cholesterol 23,24 , SBP 23 and DBP 23 (Table 3).…”

“…The results in the category of disease control were diverse. Some authors claim that there is a negative and significant correlation between SOC and the biomarkers, which suggests that people with a strong SOC will have lower triglyceride 24 , A1c 21,22,24,41 , LDL cholesterol 23 and BMI 22 levels. On the other hand, two studies suggest an indirect association between SOC and A1c, and that this relationship is mediated by health self-assessment 42 , AC, and psychopathological symptoms 43 .…”

“…In order to reduce the risk of showing results that could be influenced by other variables, 45% of the studies 20,[22][23][24][35][36][37]40,43 chose to control for variables and avoid bias in the inference of results. Different types of controlled variables were found: BMI, waist-to-hip ratio (WHR), fat intake, tobacco use and alcoholism, family his-tory of DM, physical activity and inactivity, disease-related complications and time of diagnosis; biomedical variables such as AER and ESKD; and socio-demographic and psychological variables: stress and health self-assessment.…”

“…The evaluation of SOC and disease control produced mixed results. Several studies [21][22][23][24]41 infer that SOC helps reduce the levels of biomarkers such as A1c, triglycerides, LDL cholesterol and BMI. These findings could result from the fact that people with a strong SOC consume healthy foods, are physically active and generally have a better LS 24,25,[48][49][50][51][52]54 ; several studies have documented that some healthy LS behaviors, such as: healthy dietary choices, increased physical activity, and lower tobacco consumption, reduce the level of several biomarkers that relate to this metabolic syndrome [55][56][57] .…”

“…In the case of DM, studies have not allowed for a clear understanding of the role that SOC plays, given the contradictory nature of the results. It has been reported that a high SOC prevents the development of DM 20 , helps reduce the biomarker levels that relate to disease control [21][22][23] and improves overall lifestyle (LS) 24,25 ; however, there is no other research that presents similar findings 23,26,27 .…”