Sensation seeking amongst healthy volunteers participating in phase I clinical trials.

Abstract

compared with unwilling subjects, significant differences were found in thrill-and-adventure seeking (7.9 vs 6.7, P = 0.0034), experience seeking (6.4 vs 5.2, P = 0.0012), disinhibition (6.2 vs 4.3, P < 0.0001), boredom susceptibility (3.9 vs 2.8, P = 0.0073), total sensation seeking trait (24.3 vs 19.0, P < 0.0001), extraversion (15.1 vs 13.3, P = 0.0490), and psychoticism (4.4 vs 3.5, P = 0.0086). When healthy volunteers were compared with general norm data similar statistically significant differences were found in all these scales, except for boredom susceptibility and psychoticism. 4 The personality profile of healthy volunteers was characterized by a higher sensation seeking trait and extraversion as compared with individuals who were not willing to participate in phase I clinical trials and general norm data.

“We’re giving you something so we get something in return”: Perspectives on research participation and compensation among people living with HIV who use drugs

“…Whereas previous research has shown that research participation is often influenced by compensation (Davidson & Page, 2012; Farre, Lamas, & Cami, 1995; Fry & Dwyer, 2001; Rudy, Estok, Kerr, & Menzel, 1994; Slomka et al, 2007), our findings highlight how structural vulnerability intersects with medicalized identities to shape participants’ willingness to engage in research. Participants positioned their perspectives and experiences living with HIV as a valuable resource or marketable skill to researchers.…”

The effect of education on patients' willingness to participate in a telemedicine study

“…A number of investigations have explored patients' willingness to participate in various research studies [24][25][26][27] . In a study of cancer patients' decision making and trial entry preferences, Llewellyn-Thomas et al noted that the respondent group who preferred to assume some responsibility for treatment decision making tended to be younger, included more women and reported a longer duration of formal education.…”

For love or money? An exploratory study of why injecting drug users participate in research

“…Studies have shown that people participate in research to gain access to information, 9 for economic gain, 10 for anticipated rewards to themselves and others, 4 for expected therapeutic bene ts, 6 due to feelings of moral obligation, 4 because of interviewer characteristics and inter-est in or curiosity about the research. 10 How important are these factors for explaining IDU motivations? Secondly, the question of what motivates IDUs to participate in research is relevant to human research ethics guidelines on voluntary consent.…”