SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer

Gallardo-Chamizo, Francisco; Lara-Ureña, Nieves; Correa-Vázquez, Juan F.; Reyes, José Carlos Castañeda; Gauthier, Benoit R.; García‐Domínguez, Mario

doi:10.1016/j.gendis.2022.02.019

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…We have recently shown that, in cancer cells, SENP7 is downregulated under oxygen and glucose deprivation (OGD) conditions [ 133 ], which is a feature of inner cells inside solid tumors. SENP3 protein has also been reported to be degraded under OGD through the unfolded protein response kinase PERK and the cathepsin B enzyme [ 140 ].…”

Section: Sumo Proteases In Cancermentioning

confidence: 99%

“…High SENP7 expression also associates with advanced tumor stage, which inversely correlates with SENP3 expression. Therefore, cancer cells may escape from harmful OGD conditions by upregulating SENP7 , which emerges as a putative prognosis marker in CRC [ 133 ]. Unlike SENP7, which seems to favor tumorigenesis, SENP3 has been reported to mediate antitumor functions [ 115 ].…”

Section: Sumo Proteases In Cancermentioning

confidence: 99%

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Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases

Lara-Ureña

Jafari

García‐Domínguez

2022

IJMS

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SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates. The SUMO pathway is regulated by several enzymes, proteases and ligases being the main actors involved in the control of sumoylation of specific targets. Dysregulation of the expression, localization and function of these enzymes produces physiological changes that can lead to the appearance of different types of cancer, depending on the enzymes and target proteins involved. Among the most studied proteases and ligases, those of the SENP and PIAS families stand out, respectively. While the proteases involved in this pathway have specific SUMO activity, the ligases may have additional functions unrelated to sumoylation, which makes it more difficult to study their SUMO-associated role in cancer process. In this review we update the knowledge and advances in relation to the impact of dysregulation of SUMO proteases and ligases in cancer initiation and progression.

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Section: Sumo Proteases In Cancermentioning

confidence: 99%

Section: Sumo Proteases In Cancermentioning

confidence: 99%