Senolytics: The Modern Snake Oil?

Morley, John E.

doi:10.1007/s12603-019-1202-1

Cited by 5 publications

(5 citation statements)

References 65 publications

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“…There is now an industry in trying to develop antiaging drugs. While the hype associated with these drugs is reminiscent of old fashioned "snake oil" it needs to be recognized that eventually some will have some degree of efficacy (26). The problem will be to determine what their longterm effects are -we need to be looking at 10 to 20 years of a placebo-controlled trial -not short term (3 months to a year) using surrogate endpoints.…”

Section: Figurementioning

confidence: 99%

The Future of Geriatrics

Morley

2020

The Journal of nutrition, health and aging

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Section: Figurementioning

confidence: 99%

The Future of Geriatrics

Morley

2020

The Journal of nutrition, health and aging

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“…The synergistic and multiple effects of a whole diet are crucial for effectiveness; healthy diets contain many different biologically active molecules acting on diverse molecular pathways. In the future, with adequate evidence supported by emerging research, precision nutrition with individualized recommendations of senolytic nutritional supplementation, may be possible, based on genetic background and medical conditions [71], with side effects kept at minimum [16].…”

Section: Discussionmentioning

confidence: 99%

Nutrition senolytics - illusion or reality for cognitive ageing?

Chen¹,

Brodaty

O’Leary

2021

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewCell senescence is implicated in numerous age-related conditions. Antiageing therapies and nutritional approaches have been researched for purposes of removing senescent cells (senolytics) to treat or prevent age-related diseases, such as cognitive impairment and Alzheimer's disease. In this updated review, we examined the evidence from the last 18 months regarding nutrition senolytics, with a focus on cognitive ageing among older adults. Recent findingsOverall, 19 systematic reviews and 17 intervention studies were included. Studies failed to provide evidence of nutritional senolytic agents or senescence-associated secretory phenotype (SASP) suppressors, for oral supplements providing beneficial effects on cognitive ageing among older adults. The protective role of food sources such as berries and nuts, and dietary patterns of Mediterranean diet and Mediterranean-DASH diet Intervention for Neurodegenerative Delay diet against cognitive decline or risk of dementia have been mostly supported by recent studies.

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“…A better understanding of the biology of aging also paves the way to potentially promising pharmacological interventions linked to several hallmarks of aging, including senolytics (69), inflammasome inhibitors (84), metformin (107), rapamycin (108), resveratrol (109,110) and mesenchymal stem cells (111). One could argue that improving the detection of frailty and functional loss and the implementation of personalized non-pharmacological interventions is more likely to increase healthy aging in populations than new or repurposed drugs (112). Biomarkers of healthy aging could nevertheless become useful as complementary tools to stratify the risk of functional loss and to monitor response to lifestyle interventions.…”

Section: Discussionmentioning

confidence: 99%

Revisiting the Hallmarks of Aging to Identify Markers of Biological Age

et al. 2019

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The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life expectancy in healthy aging is not increasing as fast as lifespan. The identification of biomarkers of aging is critical to predict adverse outcomes during aging, to implement interventions to reduce them, and to monitor the response to these interventions. In this narrative review, we gathered information about biomarkers of aging under the perspective of Geroscience. Based on the current literature, for each hallmark of biological aging, we proposed a putative biomarker of healthy aging, chosen for their association with mortality, age-related chronic diseases, frailty and/or functional loss. We also discussed how they could be validated as useful predictive biomarkers.

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Senolytics: The Modern Snake Oil?

Cited by 5 publications

References 65 publications

The Future of Geriatrics

The Future of Geriatrics

Nutrition senolytics - illusion or reality for cognitive ageing?

Revisiting the Hallmarks of Aging to Identify Markers of Biological Age

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