Senolytic effects of exercise in human muscles require acute inflammation
Wei-Horng Jean,
Yin-Chou Lin,
Pei-Yao Ang
et al.
Abstract:Higher intensity exercise, despite causing more tissue damage, improved aging conditions. We previously observed decreased p16
INK4a
mRNA in human skeletal muscle after high-intensity interval exercise (HIIE), with no change following equivalent work in moderate-intensity continuous exercise. This raises the question of whether the observed senolytic effect of exercise is mediated by inflammation, an immune response induced by muscle damage. In this study, inflammation was blocked using … Show more
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