Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells
Mohammad Mahbubul Hoque,
Yuichi Iida,
Hitoshi Kotani
et al.
Abstract:IntroductionGemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence. Certain drugs, including the Bcl‐2‐family inhibitor ABT‐263, kill senescent cells; this is termed senolysis. In this study, we examined the therapeutic benefits of ABT‐263 in GEM‐induced senescence of human pancreatic cancer cells.Methods and ResultsOf four pancreatic cancer cell line… Show more
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