Senkyunolide I protects rat brain against focal cerebral ischemia–reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3

Hu, Yang-ye; Duan, Muyin; Liang, Shuang; Wang, Yuan; Feng, Yi

doi:10.1016/j.brainres.2015.02.015

Cited by 70 publications

(55 citation statements)

References 29 publications

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“…Numerous studies have reported that Nrf2 plays a critical role in counteracting inflammation across a variety of experimental models [7]. The main function of Nrf2 is to activate the antioxidant response and induce the transcription of a wide range of genes that are able to counteract the harmful effects of oxidative stress, thus restoring intracellular homeostasis [8].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

Wang

Gao

et al. 2016

PLoS ONE

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The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Recently, quercetin has been proved to have a protective effect against mitochondria damage after traumatic brain injury (TBI). However, its precise role and underlying mechanisms in traumatic brain injury are not yet fully understood. The aim of the present study was to investigate the effect of quercetin on the potential mechanism of these effects in a weight-drop model of TBI in male mice that were treated with quercetin or vehicle via intraperitoneal injection administrated 30 min after TBI. In this experiment, ICR mice were divided into four groups: A sham group, TBI group, TBI + vehicle group, and TBI + quercetin group. Brain samples were collected 24 h later for analysis. Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment. Quercetin markedly promoted the translocation of Nrf2 protein from the cytoplasm to the nucleus. These observations suggest that quercetin improves mitochondrial function in TBI models, possibly by activating the Nrf2 pathway.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

Wang

Gao

et al. 2016

PLoS ONE

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“…MCAO followed by 72-hr reperfusion was described [49,50]. In addition, various authors showed that pharmacological inhibition or molecular blockage of active caspase-3, including rhEpo administration, significantly decreases infarct size or attenuates the loss of hippocampal CA1 neurons after transient cerebral ischaemia [17,48,49]. We found that after administration of rhEpo, decrease in caspase-3 over-expression was not statistically significant, thus indicating that in our experimental conditions, administration of 5000 IU rhEpo was not able to prevent caspase-3-dependent apoptotic cell death.…”

Section: Discussionmentioning

confidence: 99%

Decrease in Oxidative Stress Parameters after Post‐Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia

Mršić-Pelčić

Pilipović

Pelčić

et al. 2017

Basic Clin Pharma Tox

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Recombinant human erythropoietin (rhEpo) is a multi-functional drug with antioxidant potential. However, the underlying molecular mechanisms of its action are still unclear. The purpose of this study was to investigate the effects of rhEpo on the brain infarct volume as well as on the levels of the neuronal damage, oxidative stress parameters and active caspase-3, nuclear factor erythroid 2-related factor 2 (Nrf2) and haemeoxygenase-1 (HO-1) expressions in the hippocampi of rats exposed to the right middle cerebral artery occlusion (MCAO) for 1 hr. Ischaemic animals received either vehicle or rhEpo (5000 IU/kg, i.p.) immediately or 3 hr after the induction of ischaemia. Sham-operated, vehicle-treated animals served as the control group. Rats were killed 24 hr after the onset of the ischaemic or sham experimental procedure. MCAO caused ipsilateral brain infarction within the striatum and cortex. In the CA1 region of the hippocampi, we did not find significant neuronal loss, but a statistically significant rise in the active caspase-3 and Nrf2 protein expressions was registered. We detected also significant increases in the hippocampal levels of oxidative stress parameters (thiobarbituric acid-reactive substances, superoxide dismutase, glutathione peroxidase). Post-ischaemic administration of rhEpo significantly reduced the brain infarct volume, decreased levels of all tested oxidative stress parameters and increased the Nrf2 expression level. These findings suggest that decrease in oxidative stress parameters in the hippocampus could be an early indicator of post-ischaemic neuroprotective effect of rhEpo in rats exposed to focal cerebral ischaemia and that this effect could be attributable to additional post-ischaemic activation of Nrf2 endogenous antioxidant system.

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“…, ), ligustilide (Peng et al . , ) and senkyunolide I (Hu, Duan, Liang, & Wang, ) from L. wallichiii are active anti‐cerebral ischemia substances. Future pharmacokinetics research on NMT is required for determining whether the absorbed constituents can be maintained at effective concentrations over time in blood.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, 3′methoxypuerarin and daidzein could protect rats against cerebral ischemia-reperfusion injury (Aras et al, 2015;Liu et al, 2010). Moreover, ferulic acid (Cheng et al, 2010), ligustilide (Peng et al, 2013) and senkyunolide I (Hu, Duan, Liang, & Wang, 2015) from L. wallichiii are active anti-cerebral ischemia substances. Future pharmacokinetics research on NMT is required for determining whether the absorbed constituents can be maintained at effective concentrations over time in blood.…”

Section: Analysis Of Constituents Of L Wallichiiimentioning

confidence: 98%

LC–high‐resolution–MS/MS analysis of chemical compounds in rat plasma after oral administration of Nao‐Mai‐Tong and its individual herbs

Rong

Shao

et al. 2017

Biomedical Chromatography

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Nao-Mai-Tong (NMT), a Chinese herbal formula, is used for treating ischemia cerebral apoplexy. To discover the components of NMT with potential in vivo bioactivity and investigate the differences between NMT and its single herb components, this study rigorously compared plasma samples collected from rats dosed with NMT and single-herb extracts at different times through LC-high resolution-MS/MS and data processing (Metworks). The plasma of the NMT group contained a total of 66 identified compounds (25 prototypes and 41 metabolites), including anthraquinones, triterpenoid saponins, isoflavones and phthalides. Additionally, glucuronidation, sulfation and cysteine conjugation were the major reactions through which the compounds in NMT were metabolized. The comparison of the groups revealed two metabolites that were only detected in the plasma from the NMT-dosed group, whereas seven prototype ingredients (chrysophanol-8-O-glucoside, ginsenoside Rf, Rg2, Rh1, F1, F2 and chikusetsusaponin IVa) and 12 metabolites (two novel triterpenoid saponins) were only discovered in the plasma samples from the single-herb-dosed groups. Moreover, the trends in the chemical compounds detected presented marked differences between NMT-dosed rat plasma and plasma samples from the single-herb-dosed groups. The above data indicate that prescription compatibility affects the assimilation and elimination of ingredients and provides useful information for further pharmacokinetic studies.

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Senkyunolide I protects rat brain against focal cerebral ischemia–reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3

Cited by 70 publications

References 29 publications

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

Decrease in Oxidative Stress Parameters after Post‐Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia

LC–high‐resolution–MS/MS analysis of chemical compounds in rat plasma after oral administration of Nao‐Mai‐Tong and its individual herbs

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