Senkyunolide I attenuates oxygen-glucose deprivation/reoxygenation-induced inflammation in microglial cells

Hu, Yang-ye; Wang, Yuan; Liang, Shuang; Yu, Xueli; Zhang, Lei; Feng, Linyin; Feng, Yi

doi:10.1016/j.brainres.2016.08.012

Cited by 34 publications

(16 citation statements)

References 45 publications

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“…Moreover, stachydrine, leonurine, ferulic acid and Z -ligustilide might mediate the expressions of F2, HIF1α, and EPOR to improve blood circulation, thus exerting the effects of immune enhancement, erythrocyte synthesis and blood-vessel dilation ( Bi et al, 2012 ). Senkyunolide I may interact with MAPK1, IL-1β, and TNF-α, which were also involved in anemia and vascular systems ( Hu et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia

et al. 2018

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As a well-known traditional Chinese medicine (TCM) prescription, Xin-Sheng-Hua Granule (XSHG) has been applied in China for more than 30 years to treat postpartum diseases, especially anemia. However, underlying therapeutic mechanisms of XSHG for anemia were still unclear. In this study, plasma metabolomics profiling with UHPLC-QTOF/MS and multivariate data method was firstly analyzed to discover the potential regulation mechanisms of XSHG on anemia rats induced by bleeding from the orbit. Afterward, the compound-target-pathway network of XSHG was constructed by the use of network pharmacology, thus anemia-relevant signaling pathways were dissected. Finally, the crucial targets in the shared pathways of metabolomics and network pharmacology were experimentally validated by ELISA and Western Blot analysis. The results showed that XSHG could exert excellent effects on anemia probably through regulating coenzyme A biosynthesis, sphingolipids metabolism and HIF-1α pathways, which was reflected by the increased levels of EPOR, F2, COASY, as well as the reduced protein expression of HIF-1α, SPHK1, and S1PR1. Our work successfully explained the polypharmcological mechanisms underlying the efficiency of XSHG on treating anemia, and meanwhile, it probed into the potential treatment strategies for anemia from TCM prescription.

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Section: Resultsmentioning

confidence: 99%

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia

et al. 2018

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“…In recent studies, LC has been shown to possess anti-inflammatory properties via suppression of proinflammatory cytokines [ 25 , 29 ]. Usually, lipopolysaccharides (LPS) act as an endotoxin to induce the production of many proinflammatory cytokines in both in vitro and in vivo assays to study the anti-inflammatory properties of an active component.…”

Section: Molecular Mechanisms Of Lc's Anti-inflammatory Antioxidamentioning

confidence: 99%

“…In a study by Mahmoud et al, ferulic acid has been found to block the NF- κ B pathway which is activated by ROS [ 47 ]. Moreover, Hu et al proposed that senkyunolide I, another bioactive compound in LC, is able to reduce the ROS-induced production of TNF- α , IL-1 β , IL-6, and IFN- γ in BV-2 cells [ 29 ].…”

Section: Molecular Mechanisms Of Lc's Anti-inflammatory Antioxidamentioning

confidence: 99%

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti‐Inflammatory, Antioxidant, and Antiapoptotic Activities

Shi

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Ligusticum chuanxiong (LC) is a Chinese materia medica which is widely used in clinical settings to treat headaches, blood extravasation, and arthritis. Recent studies demonstrate that LC possesses versatile pharmacological functions, including antiatherosclerosis, antimigraine, antiaging, and anticancer properties. Moreover, LC also shows protective effects in the progression of different diseases that damage somatic cells. Oxidative stress and inflammation, which can induce somatic cell apoptosis, are the main factors associated with an abundance of diseases, whose progresses can be reversed by LC. In order to comprehensively review the molecular mechanisms associated with the protective effects of LC, we collected and integrated all its related studies on the anti-inflammatory, antioxidant, and antiapoptotic effects. The results show that LC could exhibit the mentioned biological activities by modulating several signaling pathways, specifically the NF-κB, Nrf2, protein kinase, and caspase-3 pathways. In future investigations, the pharmacokinetic properties of bioactive compounds in LC and the signaling pathway modulation of LC could be focused.

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“…For instance, ERK5 activity seems to be protective while ERK1/2, c-Jun N-terminal kinase (JNK), and p38 may add to brain damage by increasing inflammation. [ 27 28 29 30 31 32 33 ] Accordingly, inhibition of ERK1/2, JNK, and p38 has been shown to decrease brain inflammation and improve functional recovery. [ 34 35 36 37 ] Stimulation of ERK1/2 pathway, however, may also paradoxically reduce injury by blocking apoptosis and release of trophic factors after global brain ischemia.…”

Section: Pathophysiology Of Brain Injury After Cardiac Arrestmentioning

confidence: 99%

Hypothermia and brain inflammation after cardiac arrest

2018

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The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations.

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Senkyunolide I attenuates oxygen-glucose deprivation/reoxygenation-induced inflammation in microglial cells

Cited by 34 publications

References 45 publications

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti‐Inflammatory, Antioxidant, and Antiapoptotic Activities

Hypothermia and brain inflammation after cardiac arrest

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