Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and &amp;alpha;-synuclein signaling

Gong, Shenglan; Zhang, Jin; Guo, Zengjun; Fu, Wenjun

doi:10.2147/dddt.s161748

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…Oxidative stress is one of the major factors that induce mitochondria‐mediated neuronal apoptosis (Méndez‐Armenta, Nava‐Ruíz, Juárez‐Rebollar, Rodríguez‐Martínez, & Yescas Gómez, 2014; Poh Loh et al., 2006). Besides, evidence shows that prolonged exposure to high concentrations of CORT can induce mitochondrial dysfunction and neuronal apoptosis (Gong, Zhang, Guo, & Fu, 2018; B. Liu et al., 2011; Woo et al., 2018). Additionally, the neuroprotective effect of RA, the main phytochemical content of MO, has been demonstrated in a large body of studies, and is mainly through suppression of oxidative stress and the apoptosis pathway (Cui et al., 2018; Khamse et al., 2018; H. J. Lee et al., 2008; Taram, Ignowski, Duval, & Linseman, 2018).…”

Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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This study evaluated the effects of a hydro-alcoholic extract of Melissa officinalis (HAEMO) on anxiety-and depressive-like behaviours, oxidative stress and apoptosis markers in restraint stress-exposed mice. In order to induce a depression-like model, mice were subjected to restraint stress (3 h day −1 for 14 days) and received normal saline or HAEMO (50, 75 and 150 mg kg −1 day −1 ) for 14 days. The administered doses of HAEMO were designated based on the concentration of one of the main phenolic compounds present in the extract, rosmarinic acid (2.55 mg kg −1 at lowest dose); other phytochemical analyses including assays for antioxidant activity, total phenols and flavonoids were also carried out. The behavioural changes in an open field task, elevated plus maze, tail suspension and forced swimming tests were evaluated. Also, malondialdehyde (MDA) levels and enzyme activities of superoxide dismutase and glutathione peroxidase, and total antioxidant capacity were assessed in the prefrontal cortex and hippocampus. Moreover, levels of Bcl-2, Bax and caspase 3 in the brain as well as serum concentration of corticosterone were evaluated. HAEMO (75 and 150 mg kg −1 ) significantly reversed anxiety-and depressive-like behaviours. Also, HAEMO reduced MDA levels, enhanced enzymatic antioxidant activities and restored serum levels of corticosterone. An immunoblotting analysis also demonstrated that HAEMO decreased levels of pro-apoptotic markers and increased anti-apoptotic protein levels in the prefrontal cortex and hippocampus of restraint stress-exposed mice. Our findings suggested that HAEMO reduced inflammation and had anxiolytic and antidepressant effects in mice.

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Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Ghazizadeh

Hamedeyazdan

Torbati

et al. 2020

Experimental Physiology

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“…In recent years, SenA received increasing attention for its anti-spasmodic and neuroprotective effects (Gong et al. 2018 ; Zheng et al. 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway

Shao

Zhou

et al. 2022

Pharmaceutical Biology

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Context Osteoarthritis (OA) is a degenerative disease. Senkyunolide A (SenA) is an important phthalide from Ligusticum chuanxiong Hort (Umbelliferae) with anti-spasmodic and neuroprotective effects. Objective We explored the effect of SenA on IL-1β-stimulated chondrocytes and OA mice Materials and methods Chondrocytes were stimulated by IL-1β (10 ng/mL) to establish an OA model in vitro . Cells were treated with SenA (20, 40, 80 and 160 μg/mL) for 48 h. The in vivo OA model was established by cutting off the medial meniscus tibial ligament (MMTL) at right knee incision of male C57BL/6 mice. One week after surgery, mice were injected with SenA (intraperitoneally one week) and divided into four groups ( n = 6 per group): Sham, OA, OA + SenA 20 mg/kg and OA + SenA 40 mg/kg. The OA progression was examined by haematoxylin and eosin (H&E) staining. Results SenA treatment increased cell viability (33%), proliferation (71%), inhibited apoptosis (21%), decreased levels of catabolic marker proteins (MMP13, 23%; ADAMTS4, 31%; ADAMTS5, 19%), increased levels of anabolic marker proteins (IGF-1, 57%; aggrecan, 75%; Col2a1, 48%), reduced levels of inflammation cytokines (TNF-α, 31%; IL-6, 19%; IL-18, 20%) and decreased levels of NLRP3 (21%), ASC (20%) and caspase-1 (29%) of chondrocytes. However, NLRP3 agonist nigericin increased levels of MMP13 (55%), ADAMTS4 (70%), ADAMTS5 (53%), decreased levels of IGF-1 (36%), aggrecan (26%), Col2a1 (25%), inhibited proliferation (61%) and promoted apoptosis (76%). Discussion and conclusions SenA alleviates OA progression by inhibiting NLRP3 signalling pathways. These findings provide an experimental basis for the clinical application of drugs in the treatment of OA.

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“…For instance, 3-n-butylphthalide is well-known for its neuroprotective properties; it is currently used for the treatment of ischemic stroke and is also a promising therapeutic agent in Alzheimer's disease, vascular dementia, Parkinson's disease, and amyotrophic lateral sclerosis [Huang et al, 2018;Salehi et al, 2019]. Sedanenolide (aka senkyunolide A) was demonstrated to possess antiatherogenic [Lei et al, 2019], neuroprotective [Gong et al, 2018], and cancer-preventive activities [Liu et al, 2018]. Another phthalide constituent of celery, sedanolide, showed a chemopreventive potential in mice [Zheng et al, 1993] and human liver cancer cells [Hsieh et al, 2015].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds

Kokotkiewicz¹,

Badura²,

Tabaczynska³

et al. 2021

Pol. J. Food Nutr. Sci.

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The essential oil of celery (Apium graveolens) is characterized by exceptionally high content of alkylphthalides. The mentioned compounds exhibit a number of biological effects (including hypotensive, lipid-lowering, neuroprotective, and cytotoxic) and are also responsible for distinctive aroma of the plant. In the current work, parameters of conventional hydrodistillation (HD) and simultaneous distillation-extraction (SDE) were optimized to obtain phthalide-enriched fractions of celery seeds. A positive correlation was shown between hydrodistillation time and improved essential oil and phthalide yields. The 6-h HD of comminuted seeds yielded essential oil (2.9%) with a higher total phthalide content (51%), as compared to the samples collected after 1.5-3.0 h, which gave 2.4-2.7% of oil containing 24.6-39.2% of total phthalides. The oil contained sedanenolide (36.7%), 3-n-butylphthalide (13.1%), and sedanolide (1.1%). A further increase in the total phthalide content was achieved by omitting the size reduction step prior to hydrodistillation (68.8%) and utilization of the salting-out effect (84.3%). Enzyme pretreatment had a negligible effect on essential oil and phthalide yields. The change of distillation mode from HD to SDE significantly increased the oil yield of whole seeds (from 2.8 to 5.8% for 6 h processing) while maintaining its high phthalide content (62.5%), which translated to an increase in the total phthalide yield from 19.4 to 36.0 g/kg.

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Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling

Cited by 12 publications

References 34 publications

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway

Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds

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