Background. Butler University College of Pharmacy and Health Sciences (COPHS) developed a mentoring program between students enrolled in the Freshmen Health Sciences Seminar (PX100) and student-pharmacists in the first through third professional years, with the goal of better preparing the preprofessionals for the college's curriculum. Methods. Mentees were randomly assigned to mentors. The course required 3 contacts, with formal documentation of each, and a reflective assessment of the experience. Upon completing the semester, we evaluated the program by considering the types and methods of contacts, positive or negative reactions, and recommendations for future improvement. Results. The majority of students gave the program high ratings, with 74% of the mentees and 64% of the mentors reporting a positive experience. Conclusion. We expect the mentoring experience will continue as a means of informing future preprofessional students about the pharmacy program's requirements and of fostering professional growth.