Abstract:Abnormal bone remodeling of subchondral bone is associated with osteoclast formation during early osteoarthritis (OA) while senescent phenotypes are detected during osteoclast differentiation. However, the associations between cellular senescence and osteoclastogenesis remain unclear in early OA. The present study found that Nox4 positively regulated the senescence of OCPs to promote multinucleated osteoclastogenesis. Overexpression of Nox4 induced overproduction of ROS, thereby promoting senescence of OCPs. S… Show more
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