Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation

Wu, Cheng; Wang, Yu; Jin, Bo; Hao, Chenyang; Xie, Bu‐Shan; Mao, Zebin

doi:10.1074/jbc.m115.661785

Cited by 41 publications

(38 citation statements)

References 42 publications

(49 reference statements)

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“…Additionally, in human fetal lung diploid fibroblasts (2BS), it has been found that a senescence‐associated lncRNA interacted with the nuclear factor of activated T‐cells 90 kDa (NF90), a RNA binding protein suppressing miRNA biogenesis. Inhibition of NF90 may enhance the expressions of senescence‐associated miRNAs . Furthermore, mitochondrial DNA‐transcribed lncRNA (ASncmtRNA‐2) also played a vital role in age‐associated cardiovascular diseases by participating in the cell cycle arrest at G2/M phase, possibly through the production of hsa‐miR‐4485 and hsa‐miR‐1973 …”

Section: Character Of Altered Lncrnas During Tissue and Organ Agingmentioning

confidence: 99%

Long non‐coding RNAs in aging organs and tissues

Xing

Gao

Mao

et al. 2017

Clin Exp Pharma Physio

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SummaryThe aging process directly impacts bodily functions on multiple levels, including a reduced ability to resist stress, damage and disease. Besides changes in metabolic control, the aging process coincides with the altered long non-coding RNAs (lncRNAs) expression, which are ≥200nt long class of non-protein coding RNAs. The majority of non-coding transcripts of mammalian organs and tissues are expressed in developmentally regulated and cell-type specific manners. Specific altered lncRNA level has been involved in induction and maintenance of the whole human body aging with highly specific spatial andtemporal expression patterns. Furthermore, many lncRNAs are transcribed in sense, antisense and bidirectional manners in the mammalian genome. They play a vital role in regulating organ or tissue differentiation during aging by binding with miRNA or proteins to act as a decoy. Recently, the correlation between lncRNAs and aging has been studied intensely. Here, we have summarized some examples of known and novel lncRNAs that have been implicated in the aging process in the whole mammalian body and we discuss these patterns, conservation and characters during aging. This may further promote the development of research on lncRNAs and the aging process. K E Y W O R D Saging, long non-coding RNAs, organ, tissue

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Section: Character Of Altered Lncrnas During Tissue and Organ Agingmentioning

confidence: 99%

Long non‐coding RNAs in aging organs and tissues

Xing

Gao

Mao

et al. 2017

Clin Exp Pharma Physio

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“…Furthermore, SALNR was observed to be down-regulated in both replicative and OIS [82]. It interacts with NF90, a nuclear protein that prevents the biogenesis of senescence-associated miRNAs [83].…”

Section: Functions Of Lncrnas In Different Types Of Senescencementioning

confidence: 99%

Shining the Light on Senescence Associated LncRNAs

Ghanam¹,

Xu²,

Ke³

et al. 2017

Aging and disease

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Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. This process was originally described as an event that primary cells go through after many passages of cells during cell culture. More recently, cellular senescence is viewed as a programmed process by which the cell displays a senescence phenotype when exposed to a variety of stresses. Cellular senescence has been implicated in tumor suppression and aging such that senescence may contribute to both tumor progression and normal tissue repair. Here, we review different forms of cellular senescence, as well as current biomarkers used to identify senescent cells in vitro and in vivo. Additionally, we highlight the role of senescence-associated long noncoding RNAs (lncRNAs).

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“…Thus, SALNR antagonizes NF90 translocation into nucleolus and rescues its inhibitory activity on senescence-associated miRNA expression. Their data suggest that lncRNA SALNR controls cellular senescence through modulating NF90 localization (103). …”

Section: Activation Of Senescence Through Other Pathwaysmentioning

confidence: 99%

Role of lncRNAs in Cellular Aging

Degirmenci

Sun

2016

Front. Endocrinol.

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Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.

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Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation

Cited by 41 publications

References 42 publications

Long non‐coding RNAs in aging organs and tissues

Long non‐coding RNAs in aging organs and tissues

Shining the Light on Senescence Associated LncRNAs

Role of lncRNAs in Cellular Aging

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