Senescence and the Renal Vasculature in Normal Man

Hollenberg, Norman K.; Adams, Douglass F.; Solomon, Harold S.; Rashid, Abdur; Abrams, Herbert L.; Merrill, John P.

doi:10.1161/01.res.34.3.309

Cited by 343 publications

(168 citation statements)

References 22 publications

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“…Percutaneous selective renal arterial catheterization, the determination of renal blood flow with radioactive xenon and external probe counting, and cardiovascular monitoring during the administration of vasoactive agents have been described in detail (16). The catheter was used for the continuous monitoring of blood pressure and heart rate, for the injecting of xenon, and for drawing arterial blood samples.…”

Section: Techniquesmentioning

confidence: 99%

Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.

Hollenberg¹,

Williams²,

Burger³

et al. 1976

J. Clin. Invest.

171

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A B S T R A C T We have assessed the capacity of an analogue of angiotensin II (A II), 1-Sar, 8-Ala A II (P113) in normal man to stimulate and block responses to A II in four systems: blood pressure was monitored directly from an arterial catheter, and renal blood flow was measured with 1'Xe and arterial renin and aldosterone concentrations by radioimmunoassay. The 31 normal subjects were in balance on a daily intake of 200 meq sodium and 100 meq potassium to suppress endogenous renin.P113 administered intravenously induced a dose-related renal blood flow reduction, with a threshold dose of 0.1 AgAg/min. This dose also induced a small but significant increase in arterial blood pressure and plasma aldosterone as well as a reduction in plasma renin activity. In contrast to its effect on the renal vasculature, no tendency to a progressive response in the latter three parameters was noted as the P113 dose was increased 30-fold, to 3.0 sg/kg/min. P113 also reduced the clearance of para-aminohippurate, creatinine, sodium, and potassium, a pattern similar to that induced by A II.P113 at 0.1 ug/kg/min reduced significantly the blood pressure and renal vascular and aldosterone responses to graded doses of A II. Higher P113 doses totally obliterated all three responses to A II infused at 10 ng/kg/ min, a dose that provides arterial A II concentrations in the range found in angiotensin-mediated hypertension.When A II was infused first, to induce a pressor, renal vascular, and aldosterone response, P113 induced a dose-related reversal of the response in each system. In conclusion, P113 is a partial agonist in normal man, inducing an angiotensin-like response in settings in which endogenous A II is not playing a tonic role, and

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Section: Techniquesmentioning

confidence: 99%

Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.

Hollenberg¹,

Williams²,

Burger³

et al. 1976

J. Clin. Invest.

171

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“…In infant beagle mesenteric arteries, moderate contractions appear to be masked by marked relaxations. Hollenberg et al, (1974) have also observed a greater dilatation of renal vasculature to acetylcholine in 20 year old healthy volunteers than in older subjects (up to 70 years old).…”

Section: Discussionmentioning

confidence: 68%

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

Shimizu

Toda

1986

British J Pharmacology

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1 Responses to vasodilator agents were compared in helical strips ofmesenteric arteries from beagles of different ages (30 days, 3 months, 2 years and 12 years old), precontracted with prostaglandin F2% (PGFu). Relaxations induced by isoprenaline and adenosine were related inversely to age, whereas those induced by PGI2 and K+ (5 mM) did not alter with age. 2 Acetylcholine-induced relaxations were less in the arteries from the aged (12 year old) beagles than in those from the younger beagles. Histamine-induced relaxations related directly to age between 30 days and 2 years. Acetylcholine-induced relaxation was reversed to a contraction in infant (30 day old) beagle arteries by removal of the endothelium, and significantly attenuted in the older beagle arteries. In adult (2 year old) and aged beagle arteries, removal of the endothelium attenuated the histamineinduced relaxation. Treatment with indomethacin reversed the histamine-induced relaxation to a marked contraction in aged beagle arteries.3 It may be concluded that responses mediated by B-adrenoceptors and PI-purinoceptors are less in aged mesenteric arteries than in those from the younger beagles, whereas responses mediated by PGI2 receptors and the electrogenic Na+ pump do not alter with age. The release of endothelium-derived relaxing factor(s) by acetylcholine appears to be inversely related to age. However, the release of PGI2 possibly caused by histamine may be less in infant beagle mesenteric arteries than in those from the older beagles.

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“…Furthermore these changes may be aggravated by atherosclerosis [33], blood hypertension [34,35], smoking [33,34], dyslipidemia [34], obesity [36,37], and diabetes [6,38] which are highly prevalent in older [32,39,40]. Similar changes, with a decrease in renal blood flow by about 10 percent per decade, particularly to the renal cortex have been further documented [32,41]. Moreover animal studies suggest that another functional abnormality in aging is an increase in glomerular basement membrane permeability, leading to an increase in urinary excretion of proteins, including albumin [42].…”

Section: The Marginal Kidneymentioning

confidence: 86%

Expanded Criteria Donors in Kidney Transplantation: The Role of Older Donors in a Setting of Older Recipients

Rosa

Muscogiuri

Sarno

2013

ISRN Transplantation

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Kidney transplantation (KT) is the therapy of choice for end-stage renal disease (ESRD). The ESRD population is aging and so are patients waiting for KT. New strategies have been made for increasing the donor and recipient pools, and as a consequence kidneys from older donors or donors with significant comorbidities, the so-called "expanded criteria donor" (ECD) kidneys, are used for transplantation. Although good outcomes have been achieved from ECD, several issues are still waiting for clarification and need to be discussed. The concept of age matching is accepted as a method to ameliorate utilization of these allografts, but an optimal and widely accepted strategy is still not defined. The development of machine perfusion and the dual kidney transplantation are techniques which further improve the outcome of transplants from ECD, but the described experiences are scarce or coming from small single institutional reports. Also due to age-related immune dysfunction and associated comorbidities, the elderly recipients are more susceptible to immunosuppression related complications (e.g., infections and malignancy), although a widely accepted and validated immunosuppressive regimen is still lacking. In this paper, we review the issues related to KT employing allografts from marginal donors with a particular interest for the elderly patients.

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Senescence and the Renal Vasculature in Normal Man

Cited by 343 publications

References 22 publications

Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.

Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.

Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle

Expanded Criteria Donors in Kidney Transplantation: The Role of Older Donors in a Setting of Older Recipients

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