Semisynthetic Tellurosubtilisin with Glutathione Peroxidase Activity

Mao, Shizhong; Dong, Zeyuan; Li, Xiangqiu; Liu, Xiaoman; Luo, Gaoxing; Shen, Jiacong

doi:10.1021/ja052451v

Cited by 77 publications

(56 citation statements)

References 28 publications

(25 reference statements)

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“…[2][3][4] Owing to its biological importance, considerable efforts have been devoted to mimicking the properties of GPx in recent years. Up to now, a large number of GPx mimics have been reported, with model systems from small molecular organoselenium/tellurium compounds [5][6][7][8][9][10][11] such as diphenyl diselenide (PhSeSePh), ebselen and seleno/telluro-cyclodextrin, to macromolecule-based models, such as seleno-dendrimer, seleno/telluro-GST and telluro-subtilisin, [12][13][14] and to nanoenzyme models. [15][16][17][18] Some of these mimics demonstrated good enzymetic properties, high catalytic efficiency and substrate specificity.…”

Section: Introductionmentioning

confidence: 99%

Construction of Smart Glutathione Peroxidase Mimic Based on Hydrophilic Block Copolymer with Temperature Responsive Activity

Huang

Yin

et al. 2009

Macromolecular Bioscience

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A temperature-sensitive block copolymer (PAAm-b-PNIPAAm-Te) with a glutathione peroxidase-like active site was synthesized via ATRP. As a new glutathione peroxidase (GPx) mimic, it displays typical saturation kinetic behaviors and high catalytic activity. More importantly, the catalytic activity of the polymer can be well modulated by changing the temperature. The experiments proved that a change in the self-assembly structure of the polymer plays a key role for the modulation of catalytic activity. As a contrast, another block copolymer, PAAm-Te-b-PNIPAAm, was synthesized. In comparison with PAAm-b-PNIPAAm-Te, the different temperature dependent catalytic behavior seen further indicates that the micellar structure plays an important role in modulating the catalytic activity of the smart enzyme model.

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Section: Introductionmentioning

confidence: 99%

Construction of Smart Glutathione Peroxidase Mimic Based on Hydrophilic Block Copolymer with Temperature Responsive Activity

Huang

Yin

et al. 2009

Macromolecular Bioscience

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“…[31][32][33][34] Belonging to the family of chalcogens (group 16 of the periodic table), tellurium resembles the sulfur and selenium in many aspects, including its oxidation-responsive properties. Organic tellurium compounds are easy to be oxidized from the divalent to the tetravalent and hexavalent state.…”

Section: Tellurium-containing Polymersmentioning

confidence: 99%

Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications

Xiao

et al. 2016

Macromolecular Bioscience

300

202

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Reactive oxygen species (ROS) play important roles in cell signaling pathways, while increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress and a series of diseases. Utilizing these cell‐generated species as triggers for selective tuning polymer structures and properties represents a promising methodology for disease diagnosis and treatment. Recently, significant progress has been made in fabricating biomaterials including nanoparticles and macroscopic networks to interact with this dynamic physiological condition. These ROS‐responsive platforms have shown potential in a range of biomedical applications, such as cancer targeted drug delivery systems, cell therapy platforms for inflammation related disease, and so on.

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“…Literature has demonstrated immunomodulatory, antioxidant and anticancer properties of various organotellurides (Nogueira, Zeni & Rocha, 2004;Avila et al, 2012), semisynthetic tellurosubtilisin (Mao et al, 2005) and dendrimeric organotellurides (Francavilla et al, 2001). More sophisticated telluride molecules were synthesized from polystyrene nanoparticle via microemulsion polymerization.…”

Section: Micronucleus Testmentioning

confidence: 99%

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

Rocha

Meinerz

Allebrandt

et al. 2014

Preprint

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Organoselenium compounds have been pointed out as therapeutic agents. In contrast, the potential therapeutic aspects of tellurides have not yet been demonstrated. The present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 in mice after in vivo administration. Genotoxicity (as determined by comet assay) and mutagenicicity were used as end-points of toxicity. Subcutaneous administration of high doses of (PhSe)2 or (PhTe)2 (500 mol/Kg) caused distinct genotoxicity in mice. vivo exposure to ditelluride caused genotoxicity in mice, which may be associated with pro-oxidant effects of diphenyl ditelluride. These results indicated that exposure to ditelluride can be genotoxic to mice and the use of this compound and possibly other related tellurides must be carefully controlled.

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Semisynthetic Tellurosubtilisin with Glutathione Peroxidase Activity

Cited by 77 publications

References 28 publications

Construction of Smart Glutathione Peroxidase Mimic Based on Hydrophilic Block Copolymer with Temperature Responsive Activity

Construction of Smart Glutathione Peroxidase Mimic Based on Hydrophilic Block Copolymer with Temperature Responsive Activity

Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

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