Semisolid Systems Containing Propolis for the Treatment of Periodontal Disease: In Vitro Release Kinetics, Syringeability, Rheological, Textural, and Mucoadhesive Properties

Bruschi, Marcos Luciano; Jones, David S.; Panzeri, Heitor; Gremião, Maria Palmira Daflon; Freitas, Osvaldo de; Lara, Elza Helena Guimarã es

doi:10.1002/jps.20843

Cited by 196 publications

(230 citation statements)

References 53 publications

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“…In these instances this phase is considered a precursor of the cubic phase. In the case of lyotropic mesophases, the precursor absorbs water in situ and spontaneously builds the cubic phase (Bruschi et al, 2007;Nielsen, Schubert, Hansen, 1998).…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…These are the so-called environmental sensitive polymers and are classified as thermosensitive, e.g. poloxamers and carbomers (Bruschi et al, 2007;Park et al, 2001), pH sensitive, e.g. polyacrylic acid, presenting increased viscosity at higher pH values, glucose sensitive, e.g.…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…These properties decrease the mucociliar clearance and increase the contact time of the formulation with the mucous membrane (Bruschi et al, 2007;Nielsen, Schubert, Hansen, 1998).…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…The force most frequently evaluated in such tests is rupture tensile strength Bruschi et al, 2007;Hägerström, 2003). Generally, the equipment used is a texture analyzer (Figure 8) or a universal testing machine.…”

Section: Tests Measuring Mucoadhesive Strengthmentioning

confidence: 99%

“…This approach to confer Bioadhesion properties has been widely applied in the development of a number of drug delivery systems. Solid micro-and nano-particulate systems based on chitosan and derivatives have been the focus of several studies (Bravo-Osuna et al, 2007;Wittaya-Areekul, Kruenate, Prahsarn, 2006): microemulsions are thermodynamically stable and isotropic liquid systems, which allow the incorporation of bioadhesive molecules, such as polycarbophil (Vyas et al, 2006); colloidal dispersions of bioadhesive polymers frequently used in preparations for oral hygiene (Kockisch et al, 2001); semi-solid systems, as liquid crystalline mesophases (Bruschi et al, 2007(Bruschi et al, , 2008 and hydrogels (Bruschi et al, 2007;Huang et al, 2000), which can increase the contact time between preparation and mucous membrane after they undergo in situ gelation.…”

Section: Introductionmentioning

confidence: 99%

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Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

247

181

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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.Uniterms: Mucoadhesion. Bioadhesion. Mucoadhesive systems. Drugs/delivery. O efeito de fármacos pode ser potencializado através do desenvolvimento de novos sistemas de liberação como os sistemas mucoadesivos. Estes sistemas permanecem em contato íntimo com o tecido de absorção, as mucosas, liberando o fármaco no local de ação, com o consequente aumento da biodisponibilidade, podendo promover efeitos locais e sistêmicos. A mucoadesão, atualmente, é explicada por seis teorias, a eletrônica, da adsorção, da molhabilidade, da difusão, da fratura e a mecânica. Para estudar seus mecanismos e quantificá-la, são propostas várias metodologias in vitro e in vivo. Porém, a mucoadesão ainda não é totalmente compreendida. Esse trabalho tem por objetivo revisar os mecanismos e as teorias envolvidas na mucoadesão, além de descrever as metodologias e os polímeros mais utilizados em sistemas mucoadesivos para liberação de fármacos.Unitermos: Mucoadesão. Bioadesão. Sistemas mucoadesivos. Fármacos/liberação.

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Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…These properties decrease the mucociliar clearance and increase the contact time of the formulation with the mucous membrane (Bruschi et al, 2007;Nielsen, Schubert, Hansen, 1998).…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

Section: Tests Measuring Mucoadhesive Strengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

247

181

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In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

Djekić

Mihalj

2020

Bioadhesives in Drug Delivery

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Propolis as an antidegradant and biocidal agent for natural rubber

Kmiotek

Bielinski

Piotrowska

2017

J of Applied Polymer Sci

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The numerous applications of polymers in many areas of our lives make it necessary to protect them from aging. Increases in the safety and time of polymer material exploitation demands the application of antidegradants with broad scopes of action. In this study, crude propolis, originating from two geographical regions of Poland, was used to protect peroxide‐cured natural‐rubber vulcanizates filled with silica or carbon black from degradation by oxygen, ozone, and microorganisms. Thermogravimetry analysis confirmed the stability of propolis under the curing conditions. From vulcametric torque measurements and determinations of the mechanical properties, we determined that the incorporation of propolis did not adversely affect the performance of the natural‐rubber vulcanizates. The addition of propolis to the rubber mix made the vulcanizates resistant to thermooxidative and ozone aging and protected them from biodegradation in soil and the action of microorganisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45911.

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Semisolid Systems Containing Propolis for the Treatment of Periodontal Disease: In Vitro Release Kinetics, Syringeability, Rheological, Textural, and Mucoadhesive Properties

Cited by 196 publications

References 53 publications

Mucoadhesive drug delivery systems

Mucoadhesive drug delivery systems

In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

Propolis as an antidegradant and biocidal agent for natural rubber

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