Semiological and electroencephalographic features of epilepsy with amygdalar lesion

Du, Xiaoping; Usui, Naotaka; Terada, Kiyohito; Baba, Koichi; Matsuda, Kazumi; Tottori, Takayasu; Inoue, Yushi

doi:10.1016/j.eplepsyres.2015.01.007

Cited by 11 publications

(8 citation statements)

References 21 publications

(19 reference statements)

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“…Similar to our study, the rate of lateral temporal and extra-temporal foci was found as 17.7% in patients with amygdala lesions and 20% in individuals with MTLE-HS who were included as a control group (17). Unusual foci are located at different places and the features of the patients do not indicate a specific sub-type.…”

Section: Discussionsupporting

confidence: 73%

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Investigation of Patients with Hippocampal Sclerosis Associated with Unusual Epileptic Activities

Yavuz¹,

Yener²,

Özemir³

et al. 2016

tnd

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Objective: Hippocampal sclerosis (HS) is usually associated with typical anterior temporal spikes/sharp waves in the electroencephalography (EEG). We aimed to investigate the clinical, electrophysiologic differences, and prognosis between HS patients with unusual epileptic foci in comparison with patients with typical foci. Materials and Methods:Patients diagnosed who were diagnosed as having mesial temporal lobe epilepsy with HS in our center were included. All magnetic resonance imaging (MRI) results were investigated for the presence of two major criteria of HS diagnosis, namely T1 atrophy and T2 hyperintensity. All EEG and video-EEG investigations (a total of 496) were re-evaluated for unusual epileptic activities except T1/2, F7/8, T3/4 foci. Clinical and other laboratory data were retrospectively reevaluated by two investigators and the groups with usual and unusual epileptic activities for this syndrome were statistically compared.Results: A total of 124 patients including 20 (16.1%) with unusual epileptic activities (group 1) and 104 patients with typical foci (group 2) were evaluated. We observed 11 posterior temporal (T5/T6), four frontal (F3/F4), four frontopolar (Fp1/2), two occipital (O1/O2), three central (CP/FC) unusual foci, and two generalized epileptiform discharges in these 20 patients. Impaired background activity, nonspecific interictal diffuse slowing, and atypical seizure offset patterns were more frequently observed in group 1. Forty-nine patients underwent surgery after appropriate preoperative diagnostics; there was no significant difference in the postoperative outcome between the groups despite a tendency to better prognosis in group 2. Conclusion:Our study showed that unusual epileptic foci could be seen in 16.1% of patients with HS. Although some patients with HS have these atypical interictal EEG findings, they might obtain good post-operative outcomes when preoperative diagnostics are appropriately planned. Keywords: Mesial temporal lobe epilepsy, hippocampal sclerosis, electroencephalography, prognosisAmaç: Hipokampal skleroz (HS) genelde elektroensefalografide (EEG) ön temporal elektrotlarda görülen tipik dikenler/keskin dalgalar ile ilişkilidir. Çalışmada bu odaklardan farklı lokalizasyonlarda epileptik odakların ve aktivitelerin görüldüğü olguların, tipik odakları olanlara kıyasla klinik, elektrofizyolojik özelliklerinin ve prognoz farklarının araştırılması amaçlanmıştır. Gereç ve Yöntem:Merkezimizde mezyal temporal lob epilepsisi ile giden HS tanısıyla takipli olgular çalışmaya dahil edildi. Tüm manyetik rezonans görüntülemeler (MRG) iki ana HS tanı kriterinin (hipokampal yapılarda atrofi ve T2 ya da FLAIR sekanslarında sinyal artışı) varlığı açısından incelendi. Tüm EEG ve video EEG incelemeleri (toplam 496 adet) T1/2, F7/8, T3/4 odakları dışında farklı bir alanda epileptik aktivitesi olan ve olmayan hastalar açısından incelendi. Klinik ve diğer laboratuvar incelemeleri iki araştırmacı tarafından retrospektif olarak değerlendirildi. Olağan dışı odağı olan hastalarla olağan d...

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Section: Discussionsupporting

confidence: 73%

“…Histopathologically, MTLE is known to be associated with hippocampal sclerosis (HS) (1,2,3). Magnetic resonance imaging (MRI) has been shown to be a highly sensitive diagnostic method in HS diagnosis and with 3T MRI, the rate of HS in patients with MTLE reaches nearly 28% (4).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Patients with Hippocampal Sclerosis Associated with Unusual Epileptic Activities

Yavuz¹,

Yener²,

Özemir³

et al. 2016

tnd

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“…Seizures arising in the mesial temporal lobe may have the experiential aura described above, but also early autonomic phenomena such as flushing or tachycardia. Early apnoea and tachycardia indicate involvement of amygdala [19]. These symptoms may progress to behavioural arrest, automatisms, and impaired awareness.…”

Section: Mesial Temporal Lobe Including Hippocampusmentioning

confidence: 99%

Localisation in focal epilepsy: a practical guide

et al. 2021

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The semiology of epileptic seizures reflects activation, or dysfunction, of areas of brain (often termed the symptomatogenic zone) as a seizure begins and evolves. Specific semiologies in focal epilepsies provide an insight into the location of the seizure onset zone, which is particularly important for presurgical epilepsy assessment. The correct diagnosis of paroxysmal events also depends on the clinician being familiar with the spectrum of semiologies. Here, we summarise the current literature on localisation in focal epilepsies using illustrative cases and discussing possible pitfalls in localisation.

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“…As for the characteristics of seizures, both similarities and differences between the TLE with amygdala lesion (AL) without HS (TLE-AL) and TLE with HS without AL (TLE-HS) are more or less understood [8] , [11] . Reports regarding interictal conditions also exist.…”

Section: Introductionmentioning

confidence: 99%

Working memory deficit in drug-resistant epilepsy with an amygdala lesion

Usui

Terada

Usui

et al. 2018

Epilepsy & Behavior Case Reports

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This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere.The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluorodeoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited to the right uncus for the TLE-AL group.The results suggest the importance of considering cognitive functions in the non-dominant hemisphere to prevent impairment after surgery.

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Semiological and electroencephalographic features of epilepsy with amygdalar lesion

Cited by 11 publications

References 21 publications

Investigation of Patients with Hippocampal Sclerosis Associated with Unusual Epileptic Activities

Investigation of Patients with Hippocampal Sclerosis Associated with Unusual Epileptic Activities

Localisation in focal epilepsy: a practical guide

Working memory deficit in drug-resistant epilepsy with an amygdala lesion

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